S100A12 ELISA Kit for Human(Homo sapiens) | EIAab.comS100A12 ELISA Kit for Human(Homo sapiens) | EIAab.com

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S100A12 (Gene name),

Protein S100-A12 (Protein name ), S10AC_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

S100A12;

Protein name:

Protein S100-A12;

Alternative:

Calcium-binding protein in amniotic fluid 1(CAAF1);CGRP;Extracellular newly identified RAGE-binding protein(EN-RAGE);Calgranulin-C(CAGC);S100 calcium-binding protein A12;Neutrophil S100 protein(MRP-6);p6;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium and zinc ions. Interacts with AGER and both calcium and zinc are essential for the interaction.

Function:

Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. Binds calcium, zinc and copper. Presence of zinc increases the affinity for calcium. Plays an important role in the inflammatory response. Interaction with AGER on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

92

Sequence:

50:

MTKLEEHLEG | IVNIFHQYSV | RKGHFDTLSK | GELKQLLTKE | LANTIKNIKD |

92:

KAVIDEIFQG | LDANQDEQVD | FQEFISLVAI | ALKAAHYHTH | KE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

UniGene:

SMR:

STRING:

9606.ENSP00000357726

Pfam:

String:

MIM:

Uniprot:

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ELISA Kit for Human Protein S100-A12

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E1504h

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96T

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ELISA Kit for Human Protein S100-A12

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E1504p

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ELISA Kit for Human Protein S100-A12

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ELISA Kit for Human Protein S100-A12

Cat.:

E1504b

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96T

CLIA Kit for Human Protein S100-A12

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U1504h

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96T

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CLIA Kit for Human Protein S100-A12

MSDS:

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CLIA Kit for Human Protein S100-A12

Cat.:

U1504b

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96T

CLIA Kit for Human Protein S100-A12

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U1504p

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96T

Polyclonal Antibody for Human Protein S100-A12

Polyclonal Antibody for Human Protein S100-A12

Polyclonal Antibody for Human Protein S100-A12

Polyclonal Antibody for Human Protein S100-A12

Cat.:

P1504Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Protein S100-A12

Monoclonal Antibody for Human Protein S100-A12

Monoclonal Antibody for Human Protein S100-A12

Monoclonal Antibody for Human Protein S100-A12

Protein for Human Protein S100-A12

Protein for Human Protein S100-A12

Protein for Human Protein S100-A12

Protein for Human Protein S100-A12

R&D Technical Data

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s

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Precision

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

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Recovery

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Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

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Linearity

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

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References

1.

"Human CAAF1 gene -- molecular cloning, gene structure, and chromosome mapping."
Yamamura T. , Hitomi J. , Nagasaki K. , Suzuki M. , Takahashi E. , Saito S. , Tsukada T. , Yamaguchi K.
Biochem. Biophys. Res. Commun.221:356-360(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
2.

"Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21."
Wicki R. , Marenholz I. , Mischke D. , Schaefer B.W. , Heizmann C.W.
Cell Calcium20:459-464(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
3.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Blood.
5.

"Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin."
Marti T. , Erttmann K.D. , Gallin M.Y.
Biochem. Biophys. Res. Commun.221:454-458(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-92
6.

"Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry."
Ilg E.C. , Troxler H. , Buergisser D.M. , Kuster T. , Markert M. , Guignard F. , Hunziker P. , Birchler N. , Heizmann C.W.
Biochem. Biophys. Res. Commun.225:146-150(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-92
tissue: Neutrophil.
7.

"Identification and characterization of a novel human neutrophil protein related to the S100 family."
Guignard F. , Mauel J. , Markert M.
Biochem. J.309:395-401(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21
8.

"Identification, isolation, and partial characterization of a 7.5-kDa surfactant-associated protein."
Singh G. , Katyal S.L. , Brown W.E. , Kennedy A.L. , Wong-Chong M.-L. , Gottron S.A.
Exp. Lung Res.17:559-567(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-16
9.

"Calcitermin, a novel antimicrobial peptide isolated from human airway secretions."
Cole A.M. , Kim Y.-H. , Tahk S. , Hong T. , Weis P. , Waring A.J. , Ganz T.
FEBS Lett.504:5-10(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 78-92;FUNCTION AS AN ANTIMICROBIAL PROTEIN;MASS SPECTROMETRY
tissue: Nasal mucus.
10.

"CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family."
Filipek A. , Jastrzebska B. , Nowotny M. , Kuznicki J.
J. Biol. Chem.277:28848-28852(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CACYBP
11.

"Multiple structural states of S100A12: A key to its functional diversity."
Moroz O.V. , Dodson G.G. , Wilson K.S. , Lukanidin E. , Bronstein I.B.
Microsc. Res. Tech.60:581-592(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
12.

"S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity."
Yang Z. , Yan W.X. , Cai H. , Tedla N. , Armishaw C. , Di Girolamo N. , Wang H.W. , Hampartzoumian T. , Simpson J.L. , Gibson P.G. , Hunt J. , Hart P. , Hughes J.M. , Perry M.A. , Alewood P.F. , Geczy C.L.
J. Allergy Clin. Immunol.119:106-114(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Mast cell and monocyte recruitment by S100A12 and its hinge domain."
Yan W.X. , Armishaw C. , Goyette J. , Yang Z. , Cai H. , Alewood P. , Geczy C.L.
J. Biol. Chem.283:13035-13043(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN HINGE
14.

"Human S100A12: a novel key player in inflammation?"
Pietzsch J. , Hoppmann S.
Amino Acids36:381-389(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
15.

"Anti-infective protective properties of S100 calgranulins."
Hsu K. , Champaiboon C. , Guenther B.D. , Sorenson B.S. , Khammanivong A. , Ross K.F. , Geczy C.L. , Herzberg M.C.
Antiinflamm. Antiallergy Agents Med. Chem.8:290-305(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
16.

"Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function."
Moroz O.V. , Burkitt W. , Wittkowski H. , He W. , Ianoul A. , Novitskaya V. , Xie J. , Polyakova O. , Lednev I.K. , Shekhtman A. , Derrick P.J. , Bjoerk P. , Foell D. , Bronstein I.B.
BMC Biochem.10:11-11(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH AGER
17.

"S100 Calgranulins in inflammatory arthritis."
Perera C. , McNeil H.P. , Geczy C.L.
Immunol. Cell Biol.88:41-49(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
18.

"Inflammation-associated S100 proteins: new mechanisms that regulate function."
Goyette J. , Geczy C.L.
Amino Acids41:821-842(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
19.

"The role of S100A12 as a systemic marker of inflammation."
Meijer B. , Gearry R.B. , Day A.S.
Int. J. Inflamm.2012:907078-907078(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;SUBCELLULAR LOCATION
20.

"The three-dimensional structure of human S100A12."
Moroz O.V. , Antson A.A. , Murshudov G.N. , Maitland N.J. , Dodson G.G. , Wilson K.S. , Skibshoj I. , Lukanidin E.M. , Bronstein I.B.
Acta Crystallogr. D57:20-29(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS)
21.

"Structure of the human S100A12-copper complex: implications for host-parasite defence."
Moroz O.V. , Antson A.A. , Grist S.J. , Maitland N.J. , Dodson G.G. , Wilson K.S. , Lukanidin E. , Bronstein I.B.
Acta Crystallogr. D59:859-867(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS);COPPER-BINDING
22.

"The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation."
Moroz O.V. , Blagova E.V. , Wilkinson A.J. , Wilson K.S. , Bronstein I.B.
J. Mol. Biol.391:536-551(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 2-92;ZINC-BINDING

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