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Index > Protein center > S1PR3(Gene name) > Human
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  • S1PR3 (Gene name),
  • Sphingosine 1-phosphate receptor 3 (Protein name ),  S1PR3_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    S1PR3(EDG3);
    Protein name:
    Sphingosine 1-phosphate receptor 3(S1P receptor 3;S1P3);
    Alternative:
    Sphingosine 1-phosphate receptor Edg-3(S1P receptor Edg-3);Endothelial differentiation G-protein coupled receptor 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    378
    Sequence:
    50:
    MATALPPRLQ | PVRGNETLRE | HYQYVGKLAG | RLKEASEGST | LTTVLFLVIC | 
    100:
    SFIVLENLMV | LIAIWKNNKF | HNRMYFFIGN | LALCDLLAGI | AYKVNILMSG | 
    150:
    KKTFSLSPTV | WFLREGSMFV | ALGASTCSLL | AIAIERHLTM | IKMRPYDANK | 
    200:
    RHRVFLLIGM | CWLIAFTLGA | LPILGWNCLH | NLPDCSTILP | LYSKKYIAFC | 
    250:
    ISIFTAILVT | IVILYARIYF | LVKSSSRKVA | NHNNSERSMA | LLRTVVIVVS | 
    300:
    VFIACWSPLF | ILFLIDVACR | VQACPILFKA | QWFIVLAVLN | SAMNPVIYTL | 
    350:
    ASKEMRRAFF | RLVCNCLVRG | RGARASPIQP | ALDPSRSKSS | SSNNSSHSPK | 
    378:
    VKEDLPHTAP | SSCIMDKNAA | LQNGIFCN
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    MIM:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human S1P receptor 3
    Cat.:
    E0326h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human S1P receptor 3
    Cat.:
    E0326m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human S1P receptor 3
    Cat.:
    U0326h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human S1P receptor 3
    Cat.:
    U0326m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human S1P receptor 3
    Cat.:
    P0326Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human S1P receptor 3
    Cat.:
    P0326Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human S1P receptor 3
    Monoclonal Antibody for Human S1P receptor 3
    Protein for Human S1P receptor 3
    Protein for Human S1P receptor 3

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    Linearity
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    References
    1. 1.
      "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9."
      Yamaguchi F. , Tokuda M. , Hatase O. , Brenner S.
      Biochem. Biophys. Res. Commun.227:608-614(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    2. 2.
      "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids."
      An S. , Bleu T. , Huang W. , Hallmark O.G. , Coughlin S.R. , Goetzl E.J.
      FEBS Lett.417:279-282(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    3. 3.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    5. 5.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    8. 8.
      "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5."
      Ancellin N. , Hla T.
      J. Biol. Chem.274:18997-19002(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHARMACOLOGICAL CHARACTERIZATION
    9. 9.
      "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5."
      An S. , Zheng Y. , Bleu T.
      J. Biol. Chem.275:288-296(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes."
      Himmel H.M. , Meyer Zu Heringdorf D. , Graf E. , Dobrev D. , Kortner A. , Schueler S. , Jakobs K.H. , Ravens U.
      Mol. Pharmacol.58:449-454(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPHINGOSINE 1-PHOSPHATE ACTIVATION
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