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Index > Protein center > SLC40A1(Gene name) > Human
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  • SLC40A1 (Gene name),
  • Solute carrier family 40 member 1 (Protein name ),  S40A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC40A1(MSTP079;FPN1;IREG1;SLC11A3);
    Protein name:
    Solute carrier family 40 member 1;
    Alternative:
    Iron-regulated transporter 1;Ferroportin-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Localized to the basolateral membrane of polarized epithelial cells.
    Protein Attributes:
    Sequence length:
    571
    Sequence:
    50:
    MTRAGDHNRQ | RGCCGSLADY | LTSAKFLLYL | GHSLSTWGDR | MWHFAVSVFL | 
    100:
    VELYGNSLLL | TAVYGLVVAG | SVLVLGAIIG | DWVDKNARLK | VAQTSLVVQN | 
    150:
    VSVILCGIIL | MMVFLHKHEL | LTMYHGWVLT | SCYILIITIA | NIANLASTAT | 
    200:
    AITIQRDWIV | VVAGEDRSKL | ANMNATIRRI | DQLTNILAPM | AVGQIMTFGS | 
    250:
    PVIGCGFISG | WNLVSMCVEY | VLLWKVYQKT | PALAVKAGLK | EEETELKQLN | 
    300:
    LHKDTEPKPL | EGTHLMGVKD | SNIHELEHEQ | EPTCASQMAE | PFRTFRDGWV | 
    350:
    SYYNQPVFLA | GMGLAFLYMT | VLGFDCITTG | YAYTQGLSGS | ILSILMGASA | 
    400:
    ITGIMGTVAF | TWLRRKCGLV | RTGLISGLAQ | LSCLILCVIS | VFMPGSPLDL | 
    450:
    SVSPFEDIRS | RFIQGESITP | TKIPEITTEI | YMSNGSNSAN | IVPETSPESV | 
    500:
    PIISVSLLFA | GVIAARIGLW | SFDLTVTQLL | QENVIESERG | IINGVQNSMN | 
    550:
    YLLDLLHFIM | VILAPNPEAF | GLLVLISVSF | VAMGHIMYFR | FAQNTLGNKL | 
    571:
    FACGPDAKEV | RKENQANTSV | V
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Solute carrier family 40 member 1
    Cat.:
    E1631h
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    ELISA Kit for Human Solute carrier family 40 member 1
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    E1631m
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    ELISA Kit for Human Solute carrier family 40 member 1
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    E1631r
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    CLIA Kit for Human Solute carrier family 40 member 1
    Cat.:
    U1631h
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    MSDS:
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    Packing:
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    CLIA Kit for Human Solute carrier family 40 member 1
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    U1631r
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    MSDS:
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    96T
    CLIA Kit for Human Solute carrier family 40 member 1
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    U1631m
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    MSDS:
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    Packing:
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    Polyclonal Antibody for Human Solute carrier family 40 member 1
    Cat.:
    P1631Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Solute carrier family 40 member 1
    Cat.:
    P1631Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Solute carrier family 40 member 1
    Cat.:
    P1631Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Solute carrier family 40 member 1
    Monoclonal Antibody for Human Solute carrier family 40 member 1
    Monoclonal Antibody for Human Solute carrier family 40 member 1
    Protein for Human Solute carrier family 40 member 1
    Protein for Human Solute carrier family 40 member 1
    Protein for Human Solute carrier family 40 member 1

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    References
    1. 1.
      "A novel mammalian iron-regulated protein involved in intracellular iron metabolism."
      Abboud S. , Haile D.J.
      J. Biol. Chem.275:19906-19912(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANT HFE4 ASP-77
    2. 2.
      "A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation."
      McKie A.T. , Marciani P. , Rolfs A. , Brennan K. , Wehr K. , Barrow D. , Miret S. , Bomford A. , Peters T.J. , Farzaneh F. , Hediger M.A. , Hentze M.W. , Simpson R.J.
      Mol. Cell5:299-309(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Blood.
      tissue: Testis.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-133
      tissue: Aorta.
    11. 11.
      "Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload."
      Zaahl M.G. , Merryweather-Clarke A.T. , Kotze M.J. , van der Merwe S. , Warnich L. , Robson K.J.H.
      Hum. Genet.115:409-417(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6; 16-129 AND 255-316;VARIANT HFE4 VAL-270
    12. 12.
      "Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains."
      Rungaldier S. , Oberwagner W. , Salzer U. , Csaszar E. , Prohaska R.
      Biochim. Biophys. Acta1828:956-966(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;IDENTIFICATION IN A COMPLEX WITH STOM;SUBUNIT
    13. 13.
      "Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene."
      Montosi G. , Donovan A. , Totaro A. , Garuti C. , Pignatti E. , Cassanelli S. , Trenor C.C. , Gasparini P. , Andrews N.C. , Pietrangelo A.
      J. Clin. Invest.108:619-623(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFE4 ASP-77
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFE4 HIS-144
    15. 15.
      "Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis."
      Wallace D.F. , Pedersen P. , Dixon J.L. , Stephenson P. , Searle J.W. , Powell L.W. , Subramaniam V.N.
      Blood100:692-694(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFE4 VAL-162 DEL
    16. 16.
      "Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3)."
      Devalia V. , Carter K. , Walker A.P. , Perkins S.J. , Worwood M. , May A. , Dooley J.S.
      Blood100:695-697(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFE4 VAL-162 DEL
    17. 17.
      "A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4."
      Roetto A. , Merryweather-Clarke A.T. , Daraio F. , Livesey K. , Pointon J.J. , Barbabietola G. , Piga A. , Mackie P.H. , Robson K.J.H. , Camaschella C.
      Blood100:733-734(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFE4 VAL-162 DEL
    18. 18.
      "Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3)."
      Cazzola M. , Cremonesi L. , Papaioannou M. , Soriani N. , Kioumi A. , Charalambidou A. , Paroni R. , Romtsou K. , Levi S. , Ferrari M. , Arosio P. , Christakis J.
      Br. J. Haematol.119:539-546(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFE4 VAL-162 DEL
    19. 19.
      "Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (SLC11A3) mutations."
      Hetet G. , Devaux I. , Soufir N. , Grandchamp B. , Beaumont C.
      Blood102:1904-1910(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HFE4 GLY-157; HIS-182 AND VAL-323
    20. 20.
      "Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene."
      Gordeuk V.R. , Caleffi A. , Corradini E. , Ferrara F. , Jones R.A. , Castro O. , Onyekwere O. , Kittles R. , Pignatti E. , Montosi G. , Garuti C. , Gangaidzo I.T. , Gomo Z.A.R. , Moyo V.M. , Rouault T.A. , MacPhail P. , Pietrangelo A.
      Blood Cells Mol. Dis.31:299-304(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-248
    21. 21.
      "A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient."
      Arden K.E. , Wallace D.F. , Dixon J.L. , Summerville L. , Searle J.W. , Anderson G.J. , Ramm G.A. , Powell L.W. , Subramaniam V.N.
      Gut52:1215-1217(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFE4 THR-144
    22. 22.
      "Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family."
      Rivard S.R. , Lanzara C. , Grimard D. , Carella M. , Simard H. , Ficarella R. , Simard R. , D'Adamo A.P. , De Braekeleer M. , Gasparini P.
      Haematologica88:824-826(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFE4 ASN-64
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IRON OVERLOAD ASP-490
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IRON OVERLOAD SER-80 AND ILE-174
    25. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HFE4 ASP-144 AND VAL-270;VARIANT IRON OVERLOAD TYR-326
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    27. 27.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HFE4 VAL-80; VAL-181 AND ASP-267
    28. 28.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
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