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Index > Protein center > SAA1(Gene name) > Human
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  • SAA1 (Gene name),
  • Serum amyloid A-1 protein (Protein name ),  SAA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    SAA1;
    Protein name:
    Serum amyloid A-1 protein(SAA);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Major acute phase reactant. Apolipoprotein of the HDL complex.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    122
    Sequence:
    50:
    MKLLTGLVFC | SLVLGVSSRS | FFSFLGEAFD | GARDMWRAYS | DMREANYIGS | 
    100:
    DKYFHARGNY | DAAKRGPGGV | WAAEAISDAR | ENIQRFFGHG | AEDSLADQAA | 
    122:
    NEWGRSGKDP | NHFRPAGLPE | KY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human SAA
    Cat.:
    E0885b
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    96T
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    ELISA Kit for Human SAA
    MSDS:
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    ELISA Kit for Human SAA
    Cat.:
    E0885d
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    Packing:
    96T
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    ELISA Kit for Human SAA
    Cat.:
    E0885m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human SAA
    Cat.:
    E0885h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human SAA
    MSDS:
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    CLIA Kit for Human SAA
    Cat.:
    U0885d
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human SAA
    Cat.:
    U0885b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human SAA
    Cat.:
    U0885m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Human SAA
    Cat.:
    U0885h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human SAA
    Cat.:
    P0885Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SAA
    Polyclonal Antibody for Human SAA
    Polyclonal Antibody for Human SAA
    Cat.:
    P0885Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SAA
    Monoclonal Antibody for Human SAA
    Monoclonal Antibody for Human SAA
    Monoclonal Antibody for Human SAA
    Monoclonal Antibody for Human SAA
    Monoclonal Antibody for Human SAA
    Protein for Human SAA
    Protein for Human SAA
    Protein for Human SAA
    Protein for Human SAA
    Protein for Human SAA

    R&D Technical Data
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    12% SDS-PAGE analysis

              12% SDS-PAGE analysis

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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.3%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.2%

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    Recovery
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    Recovery was determined by spiking various levels of SAA1 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    101

    95-103

    Plasma

    99

    93-106

     

     

     

     

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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of SAA1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    94-106%

    96-107%

    95-109%

    97-105%

    EDTA plasma(n=5)

    91-108%

    95-103%

    92-107%

    93-106%

    heparin plasma(n=5)

    93-104%

     

    94-106%

    90-109%

    96-104%

     

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    References
    1. 1.
      "Human serum amyloid A (SAA): biosynthesis and postsynthetic processing of preSAA and structural variants defined by complementary DNA."
      Sipe J.D. , Colten H.R. , Goldberger G. , Edge M.D. , Tack B.F. , Cohen A.S. , Whitehead A.S.
      Biochemistry24:2931-2936(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE SAA1.1)
    2. 2.
      "Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person."
      Kluve-Beckerman B. , Dwulet F.E. , Benson M.D.
      J. Clin. Invest.82:1670-1675(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE SAA1.1)
      tissue: Liver.
    3. 3.
      "The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells."
      Betts J. , Edbrooke M. , Thakker R. , Woo P.
      Scand. J. Immunol.34:471-482(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE SAA1.5)
      tissue: Liver.
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE SAA1.5)
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE SAA1.5)
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE SAA1.1)
      tissue: Liver.
    7. 7.
      "Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis."
      Steinkasserer A. , Weiss E.H. , Schwaeble W. , Linke R.P.
      Biochem. J.268:187-193(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-122;VARIANTS VAL-75 AND ASN-78
      tissue: Liver.
    8. 8.
      "Amino acid sequence of amyloid-related apoprotein (apoSAA1) from human high-density lipoprotein."
      Parmelee D.C. , Titani K. , Ericsson L.H. , Eriksen N. , Benditt E.P. , Walsh K.A.
      Biochemistry21:3298-3303(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-122;SUBCELLULAR LOCATION;SUBUNIT;TISSUE SPECIFICITY
    9. 9.
      "Human serum amyloid A protein. Complete amino acid sequence of a new variant."
      Beach C.M. , de Beer M.C. , Sipe J.D. , Loose L.D. , de Beer F.C.
      Biochem. J.282:615-620(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-122 (ALLELE SAA1.2)
    10. 10.
      "An unusually large (83 amino acid residues) amyloid fibril protein AA from a patient with Waldenstrom's macroglobulinaemia and amyloidosis."
      Moyner K. , Sletten K. , Husby G. , Natvig J.B.
      Scand. J. Immunol.11:549-554(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-101
    11. 11.
      "Amino acid sequence of an amyloid fibril protein of unknown origin."
      Ein D. , Kimura S. , Terry W.D. , Magnotta J. , Glenner G.G.
      J. Biol. Chem.247:5653-5655(1972) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-94
    12. 12.
      "The amino acid sequence of a major nonimmunoglobulin component of some amyloid fibrils."
      Levin M. , Franklin E.C. , Frangione B. , Pras M.
      J. Clin. Invest.51:2773-2776(1972) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-94 (FAMILIAL MEDITERRANEAN FEVER PATIENT)
    13. 13.
      "The complete amino-acid sequence of non-immunoglobulin amyloid fibril protein AS in rheumatoid arthritis."
      Sletten K. , Husby G.
      Eur. J. Biochem.41:117-125(1974) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-94;TISSUE SPECIFICITY
    14. 14.
      "Identification of two novel amyloid A protein subsets coexisting in an individual patient of AA-amyloidosis."
      Baba S. , Takahashi T. , Kasama T. , Shirasawa H.
      Biochim. Biophys. Acta1180:195-200(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-94;MASS SPECTROMETRY;DISEASE;VARIANTS ALA-70; VAL-75 AND ASN-78;ALLELE SAA1.3
      tissue: Thyroid.
    15. 15.
      "The complete amino acid sequence of an amyloid fibril protein AA1 of unusual size (64 residues)."
      Sletten K. , Husby G. , Natvig J.B.
      Biochem. Biophys. Res. Commun.69:19-25(1976) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-82
    16. 16.
      "The major proteins of human and monkey amyloid substance: common properties including unusual N-terminal amino acid sequences."
      Benditt E.P. , Eriksen N. , Hermodson M.A. , Ericsson L.H.
      FEBS Lett.19:169-173(1971) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-42
    17. 17.
      "Degradation and deposition of amyloid AA fibrils are tissue specific."
      Prelli F. , Pras M. , Frangione B.
      Biochemistry26:8251-8256(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-100
    18. 18.
      "Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis."
      Howard B.A. , Wang M.Z. , Campa M.J. , Corro C. , Fitzgerald M.C. , Patz E.F. Jr.
      Proteomics3:1720-1724(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-33; 44-57; 64-80 AND 86-122;TISSUE SPECIFICITY;MASS SPECTROMETRY
    19. 19.
      "Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry."
      Ducret A. , Bruun C.F. , Bures E.J. , Marhaug G. , Husby G. , Aebersold R.
      Electrophoresis17:866-876(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE (VARIOUS FORMS);METHYLATION AT ASN-101
    20. 20.
      "A protein AA-variant derived from a novel serum AA protein, SAA1 delta, in an individual from Papua New Guinea."
      Westermark P. , Sletten K. , Westermark G.T. , Raynes J. , McAdam K.P.
      Biochem. Biophys. Res. Commun.223:320-323(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF ALLELE SAA1.4
    21. 21.
      "Revised nomenclature for serum amyloid A (SAA). Nomenclature Committee of the International Society of Amyloidosis. Part 2."
      Sipe J.
      Amyloid6:67-70(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;NOMENCLATURE OF ALLELES
    22. 22.
      "Detection of novel truncated forms of human serum amyloid A protein in human plasma."
      Kiernan U.A. , Tubbs K.A. , Nedelkov D. , Niederkofler E.E. , Nelson R.W.
      FEBS Lett.537:166-170(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MASS SPECTROMETRY
    23. 23.
      "A novel polymorphism of human serum amyloid A protein, SAA1 gamma, is characterized by alanines at both residues 52 and 57."
      Baba S. , Takahashi T. , Kasama T. , Fujie M. , Shirasawa H.
      Arch. Biochem. Biophys.303:361-366(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF ALLELE SAA1.3
    24. 24.
      "Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis."
      Lu J. , Yu Y. , Zhu I. , Cheng Y. , Sun P.D.
      Proc. Natl. Acad. Sci. U.S.A.111:5189-5194(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 19-122;SUBUNIT;MUTAGENESIS OF ARG-19; ARG-33; ARG-37; ARG-65; ARG-80 AND HIS-89
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