Kitlg ELISA Kit for Mouse(Mus musculus) | EIAab.comKitlg ELISA Kit for Mouse(Mus musculus)

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Kitlg (Gene name),

Kit ligand (Protein name ), SCF_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Kitlg(Kitl;Mgf;Sl;Slf);

Protein name:

Kit ligand;

Alternative:

Mast cell growth factor(MGF);Hematopoietic growth factor KL;Stem cell factor(SCF);Steel factor;c-Kit ligand;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.

Function:

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Subcellular Location:

Soluble KIT ligand Secreted

Protein Attributes:

Sequence length:

273

Sequence:

50:

100:

150:

200:

250:

273:

IQINEEDNEI | SMLQQKEREF | QEV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.45124

Pfam:

PF02404

String:

P20826

SMR:

P20826

KEGG:

mmu:17311

Uniprot:

P20826

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ELISA Kit for Mouse Kit ligand

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E0120r

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96T

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ELISA Kit for Mouse Kit ligand

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E0120h

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96T

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ELISA Kit for Mouse Kit ligand

Cat.:

E0120m

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96T

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ELISA Kit for Mouse Kit ligand

Cat.:

E0120b

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96T

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ELISA Kit for Mouse Kit ligand

Cat.:

E0120c

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96T

ELISA Kit for Mouse Kit ligand

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E0120d

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96T

ELISA Kit for Mouse Kit ligand

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E0120p

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96T

CLIA Kit for Mouse Kit ligand

Cat.:

U0120p

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96T

CLIA Kit for Mouse Kit ligand

Cat.:

U0120c

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96T

CLIA Kit for Mouse Kit ligand

Cat.:

U0120d

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96T

CLIA Kit for Mouse Kit ligand

Cat.:

U0120r

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96T

CLIA Kit for Mouse Kit ligand

Cat.:

U0120h

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96T

CLIA Kit for Mouse Kit ligand

Cat.:

U0120b

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Manual:

Looking for manual.

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96T

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CLIA Kit for Mouse Kit ligand

Cat.:

U0120m

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96T

Polyclonal Antibody for Mouse Kit ligand

Cat.:

P0120Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Kit ligand

Cat.:

P0120Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Kit ligand

Cat.:

P0120Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Kit ligand

Monoclonal Antibody for Mouse Kit ligand

Protein for Mouse Kit ligand

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms."
Anderson D.M. , Lyman S.D. , Baird A. , Wignall J.M. , Eisenman J. , Rauch C. , March C.J. , Boswell H.S. , Gimpel S.D. , Cosman D. , Williams D.E.
Cell63:235-243(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: WCB6F1.
2.

"Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2."
Huang E.J. , Nocka K.H. , Buck J. , Besmer P.
Mol. Biol. Cell3:349-362(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2)
3.

"Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant."
Flanagan J.G. , Chan D.C. , Leder P.
Cell64:1025-1035(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2)
strain: WCB6F1.
4.

"Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail."
Brannan C.I. , Bedell M.A. , Resnick J.L. , Eppig J.J. , Handel M.A. , Williams D.E. , Lyman S.D. , Donovan P.J. , Jenkins N.A. , Copeland N.G.
Genes Dev.6:1832-1842(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
5.

"Multiple pathways for Steel regulation suggested by genomic and sequence analysis of the murine Steel gene."
Bedell M.A. , Copeland N.G. , Jenkins N.A.
Genetics142:927-934(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
strain: C57BL/6J.
6.

"Molecular analysis of two new Steel mutations in mice shows a transversion or an insertion."
Graw J. , Loester J. , Neuhaeuser-Klaus A. , Pretsch W. , Schmitt-John T.
Mamm. Genome7:843-846(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS PRO-193 AND SER-207
strain: C3H/E1.
tissue: Brain.
7.

"Detection of a point mutation (A to G) in exon 5 of the murine Mgf gene defines a novel allele at the Steel locus with a weak phenotype."
Graw J. , Neuhauser-Klaus A. , Pretsch W.
Mutat. Res.382:75-78(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS SER-122; PRO-193 AND SER-207
strain: 102/E1 X C3H/E1.
8.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6J.
tissue: Cerebellum.
tissue: Testis.
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-207
10.

"The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus."
Huang E. , Nocka K. , Beier D.R. , Chu T.Y. , Buck J. , Lahm H.W. , Wellner D. , Leder P. , Besmer P.
Cell63:225-233(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-270 (ISOFORM 1);PROTEIN SEQUENCE OF 26-65
11.

"Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor."
Zsebo K.M. , Williams D.A. , Geissler E.N. , Broudy V.C. , Martin F.H. , Atkins H.L. , Hsu R.-Y. , Birkett N.C. , Okino K.H. , Murdock D.C. , Jacobsen F.W. , Langley K.E. , Smith K.A. , Takeishi T. , Cattanach B.M. , Galli S.J. , Suggs S.V.
Cell63:213-224(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-201
12.

"Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles."
Copeland N.G. , Gilbert D.J. , Cho B.C. , Donovan P.J. , Jenkins N.A. , Cosman D. , Anderson D. , Lyman S.D. , Williams D.E.
Cell63:175-183(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-53
13.

"Identification of a ligand for the c-kit proto-oncogene."
Williams D.E. , Eisenman J. , Baird A. , Rauch C. , van Ness K. , March C.J. , Park L.S. , Martin U. , Mochizuki D.Y. , Boswell H.S. , Burgess G.S. , Cosman D. , Lyman S.D.
Cell63:167-174(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-78
14.

"Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases."
Liu H. , Chen X. , Focia P.J. , He X.
EMBO J.26:891-901(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 28-166 ALONE AND IN COMPLEX WITH KIT;SUBUNIT;DISULFIDE BONDS

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