Gene name:
Kitlg (Kitl;Mgf) ;
Protein name:
Kit ligand ;
Alternative:
Mast cell growth factor (MGF) ;Hematopoietic growth factor KL ;c-Kit ligand ;Stem cell factor (SCF) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.
Function:
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Subcellular Location:
Soluble KIT ligand
Secreted
Protein Attributes:
50:
MKKTQTWIIT | CIYLQLLLFN | PLVKTQEICR | NPVTDNVKDI | TKLVANLPND |
100:
YMITLNYVAG | MDVLPSHCWL | RDMVTHLSVS | LTTLLDKFSN | ISEGLSNYSI |
150:
IDKLGKIVDD | LVACMEENAP | KNVKESLKKP | ETRNFTPEEF | FSIFNRSIDA |
200:
FKDFMVASDT | SDCVLSSTLG | PEKDSRVSVT | KPFMLPPVAA | SSLRNDSSSS |
250:
NRKAAKSPED | PGLQWTAMAL | PALISLVIGF | AFGALYWKKK | QSSLTRAVEN |
273:
IQINEEDNEI | SMLQQKEREF | QEV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Bovine
Chicken
Dog
Pig
ELISA Kit for Rat Kit ligand
ELISA Kit for Rat Kit ligand
ELISA Kit for Rat Kit ligand
ELISA Kit for Rat Kit ligand
ELISA Kit for Rat Kit ligand
ELISA Kit for Rat Kit ligand
ELISA Kit for Rat Kit ligand
CLIA Kit for Rat Kit ligand
CLIA Kit for Rat Kit ligand
CLIA Kit for Rat Kit ligand
CLIA Kit for Rat Kit ligand
CLIA Kit for Rat Kit ligand
CLIA Kit for Rat Kit ligand
CLIA Kit for Rat Kit ligand
Polyclonal Antibody for Rat Kit ligand
Polyclonal Antibody for Rat Kit ligand
Polyclonal Antibody for Rat Kit ligand
Polyclonal Antibody for Rat Kit ligand
Polyclonal Antibody for Rat Kit ligand
Polyclonal Antibody for Rat Kit ligand
Polyclonal Antibody for Rat Kit ligand
Monoclonal Antibody for Rat Kit ligand
Monoclonal Antibody for Rat Kit ligand
Monoclonal Antibody for Rat Kit ligand
Monoclonal Antibody for Rat Kit ligand
Monoclonal Antibody for Rat Kit ligand
Monoclonal Antibody for Rat Kit ligand
Monoclonal Antibody for Rat Kit ligand
Protein for Rat Kit ligand
Protein for Rat Kit ligand
Protein for Rat Kit ligand
Protein for Rat Kit ligand
Protein for Rat Kit ligand
Protein for Rat Kit ligand
Protein for Rat Kit ligand
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
2.
"Primary structure and functional expression of rat and human stem cell factor DNAs."
Martin F.H.
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more...
Cell63:203-211(1990)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-201;PARTIAL PROTEIN SEQUENCE
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 26-190;PYROGLUTAMATE FORMATION AT GLN-26;GLYCOSYLATION AT ASN-90; ASN-134; ASN-145; SER-167; THR-168; THR-180 AND ASN-195;DISULFIDE BONDS
strain :
Buffalo .
tissue :
Liver .
4.
"Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium."
Zsebo K.M.
,
Wypych J.
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McNiece I.K.
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Lu H.S.
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Smith K.A.
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Karkare S.B.
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Cell63:195-201(1990)
[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 26-39