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Index > Protein center > SDCBP(Gene name) > Human
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  • SDCBP (Gene name),
  • Syntenin-1 (Protein name ),  SDCB1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SDCBP(MDA9;SYCL);
    Protein name:
    Syntenin-1;
    Alternative:
    Pro-TGF-alpha cytoplasmic domain-interacting protein 18(TACIP18);Melanoma differentiation-associated protein 9(MDA-9);Syndecan-binding protein 1;Scaffold protein Pbp1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer and homodimer (By similarity). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA. Interacts with neurofascin, SDCBP2 and PTPRJ.
    Function:
    Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
    Subcellular Location:
    Cell junction focal adhesion Cell junction adherens junction Cell membrane Peripheral membrane protein Endoplasmic reticulum membrane Peripheral membrane protein Nucleus Melanosome Cytoplasm cytosol Cytoplasm cytoskeleton Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    Protein Attributes:
    Sequence length:
    298
    Sequence:
    50:
    MSLYPSLEDL | KVDKVIQAQT | AFSANPANPA | ILSEASAPIP | HDGNLYPRLY | 
    100:
    PELSQYMGLS | LNEEEIRANV | AVVSGAPLQG | QLVARPSSIN | YMVAPVTGND | 
    150:
    VGIRRAEIKQ | GIREVILCKD | QDGKIGLRLK | SIDNGIFVQL | VQANSPASLV | 
    200:
    GLRFGDQVLQ | INGENCAGWS | SDKAHKVLKQ | AFGEKITMTI | RDRPFERTIT | 
    250:
    MHKDSTGHVG | FIFKNGKITS | IVKDSSAARN | GLLTEHNICE | INGQNVIGLK | 
    298:
    DSQIADILST | SGTVVTITIM | PAFIFEHIIK | RMAPSIMKSL | MDHTIPEV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Syntenin-1
    MSDS:
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    ELISA Kit for Human Syntenin-1
    Cat.:
    E14986m
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    96T
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    ELISA Kit for Human Syntenin-1
    Cat.:
    E14986h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Syntenin-1
    Cat.:
    U14986h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Syntenin-1
    Cat.:
    U14986m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Syntenin-1
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Syntenin-1
    Polyclonal Antibody for Human Syntenin-1
    Polyclonal Antibody for Human Syntenin-1
    Monoclonal Antibody for Human Syntenin-1
    Monoclonal Antibody for Human Syntenin-1
    Monoclonal Antibody for Human Syntenin-1
    Protein for Human Syntenin-1
    Protein for Human Syntenin-1
    Protein for Human Syntenin-1

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    Precision
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    Linearity
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    References
    1. 1.
      "Characterization of a novel melanoma differentiation associated gene, mda-9, that is down-regulated during terminal cell differentiation."
      Lin J.J. , Jiang H. , Fisher P.B.
      Mol. Cell. Differ.4:317-333(1996)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH SDC2;VARIANT SER-69
    3. 3.
      "A new family of scaffold proteins."
      Burbelo P.D.
      Submitted (1997-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene."
      Lin J.J. , Jiang H. , Fisher P.B.
      Gene207:105-110(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Rectum.
      tissue: Urinary bladder.
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
    8. 9.
      Bienvenut W.V. , Sumpton D.P. , Lilla S. , Ozanne B.W.
      Submitted (2009-02) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-14; 218-229 AND 289-298;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Pre-B cell.
    9. 10.
      "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands."
      Torres R. , Firestein B.L. , Dong H. , Staudinger J. , Olson E.N. , Huganir R.L. , Bredt D.S. , Gale N.W. , Yancopoulos G.D.
      Neuron21:1453-1463(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHB1 AND EPHA7
    10. 11.
      "A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface."
      Fernandez-Larrea J. , Merlos-Suarez A. , Urena J.M. , Baselga J. , Arribas J.
      Mol. Cell3:423-433(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TGFA
    11. 12.
      "Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin."
      Grootjans J.J. , Reekmans G. , Ceulemans H. , David G.
      J. Biol. Chem.275:19933-19941(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYNDECANS; NRXN2 AND EPHB1
    12. 13.
      "Schwannomin isoform-1 interacts with syntenin via PDZ domains."
      Jannatipour M. , Dion P. , Khan S. , Jindal H. , Fan X. , Laganiere J. , Chishti A.H. , Rouleau G.A.
      J. Biol. Chem.276:33093-33100(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NF2
    13. 14.
      "Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments."
      Zimmermann P. , Tomatis D. , Rosas M. , Grootjans J.J. , Leenaerts I. , Degeest G. , Reekmans G. , Coomans C. , David G.
      Mol. Biol. Cell12:339-350(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    14. 15.
      "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein."
      Geijsen N. , Uings I.J. , Pals C. , Armstrong J. , McKinnon M. , Raaijmakers J.A.M. , Lammers J.-W. , Koenderman L. , Coffer P.J.
      Science293:1136-1138(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IL5RA
    15. 16.
      "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
      Basrur V. , Yang F. , Kushimoto T. , Higashimoto Y. , Yasumoto K. , Valencia J. , Muller J. , Vieira W.D. , Watabe H. , Shabanowitz J. , Hearing V.J. , Hunt D.F. , Appella E.
      J. Proteome Res.2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Melanoma.
    16. 17.
      "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
      Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
      J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Melanoma.
    17. 18.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 20.
      "PDZ tandem of human syntenin: crystal structure and functional properties."
      Kang B.S. , Cooper D.R. , Jelen F. , Devedjiev Y. , Derewenda U. , Dauter Z. , Otlewski J. , Derewenda Z.S.
      Structure11:459-468(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) OF 113-273
    20. 21.
      "Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm."
      Kang B.S. , Cooper D.R. , Devedjiev Y. , Derewenda U. , Derewenda Z.S.
      Structure11:845-853(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 197-270 IN COMPLEXES WITH IL5RA AND SDC4
    21. 22.
      "The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography."
      Kang B.S. , Devedjiev Y. , Derewenda U. , Derewenda Z.S.
      J. Mol. Biol.338:483-493(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.73 ANGSTROMS) OF 197-273
    22. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 113-273 IN COMPLEXES WITH C-TERMINAL PEPTIDES FROM NEUREXIN; EPHB1 AND SDC4
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