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Index > Protein center > SGPL1(Gene name) > Human
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  • SGPL1 (Gene name),
  • Sphingosine-1-phosphate lyase 1 (Protein name ),  SGPL1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SGPL1(KIAA1252);
    Protein name:
    Sphingosine-1-phosphate lyase 1(S1PL;SP-lyase 1;SPL 1;hSPL);
    Alternative:
    Sphingosine-1-phosphate aldolase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type III membrane protein
    Protein Attributes:
    Sequence length:
    568
    Sequence:
    50:
    MPSTDLLMLK | AFEPYLEILE | VYSTKAKNYV | NGHCTKYEPW | QLIAWSVVWT | 
    100:
    LLIVWGYEFV | FQPESLWSRF | KKKCFKLTRK | MPIIGRKIQD | KLNKTKDDIS | 
    150:
    KNMSFLKVDK | EYVKALPSQG | LSSSAVLEKL | KEYSSMDAFW | QEGRASGTVY | 
    200:
    SGEEKLTELL | VKAYGDFAWS | NPLHPDIFPG | LRKIEAEIVR | IACSLFNGGP | 
    250:
    DSCGCVTSGG | TESILMACKA | YRDLAFEKGI | KTPEIVAPQS | AHAAFNKAAS | 
    300:
    YFGMKIVRVP | LTKMMEVDVR | AMRRAISRNT | AMLVCSTPQF | PHGVIDPVPE | 
    350:
    VAKLAVKYKI | PLHVDACLGG | FLIVFMEKAG | YPLEHPFDFR | VKGVTSISAD | 
    400:
    THKYGYAPKG | SSLVLYSDKK | YRNYQFFVDT | DWQGGIYASP | TIAGSRPGGI | 
    450:
    SAACWAALMH | FGENGYVEAT | KQIIKTARFL | KSELENIKGI | FVFGNPQLSV | 
    500:
    IALGSRDFDI | YRLSNLMTAK | GWNLNQLQFP | PSIHFCITLL | HARKRVAIQF | 
    550:
    LKDIRESVTQ | IMKNPKAKTT | GMGAIYGMAQ | TTVDRNMVAE | LSSVFLDSLY | 
    568:
    STDTVTQGSQ | MNGSPKPH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    UniGene:
    String:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human S1PL
    Cat.:
    E15015h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human S1PL
    MSDS:
    Please sign in first.
    ELISA Kit for Human S1PL
    MSDS:
    Please sign in first.
    CLIA Kit for Human S1PL
    MSDS:
    Please sign in first.
    CLIA Kit for Human S1PL
    MSDS:
    Please sign in first.
    CLIA Kit for Human S1PL
    Cat.:
    U15015h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human S1PL
    Polyclonal Antibody for Human S1PL
    Polyclonal Antibody for Human S1PL
    Monoclonal Antibody for Human S1PL
    Monoclonal Antibody for Human S1PL
    Monoclonal Antibody for Human S1PL
    Protein for Human S1PL
    Protein for Human S1PL
    Protein for Human S1PL

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22."
      Van Veldhoven P.P. , Gijsbers S. , Mannaerts G.P. , Vermeesch J.R. , Brys V.
      Biochim. Biophys. Acta1487:128-134(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CATALYTIC ACTIVITY;FUNCTION;MUTAGENESIS OF CYS-218 AND CYS-317;TISSUE SPECIFICITY
    2. 2.
      "Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis."
      Reiss U. , Oskouian B. , Zhou J. , Gupta V. , Sooriyakumaran P. , Kelly S. , Wang E. , Merrill A.H. Jr. , Saba J.D.
      J. Biol. Chem.279:1281-1290(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;MUTAGENESIS OF LYS-353
    3. 3.
      "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Kikuno R. , Hirosawa M. , Nomura N. , Ohara O.
      DNA Res.6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
    7. 7.
      "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry."
      Zhan X. , Desiderio D.M.
      Anal. Biochem.354:279-289(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-356 AND TYR-366;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Pituitary adenoma.
    8. 8.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-564;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-353;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis."
      Weiler S. , Braendlin N. , Beerli C. , Bergsdorf C. , Schubart A. , Srinivas H. , Oberhauser B. , Billich A.
      J. Med. Chem.57:5074-5084(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 62-568 IN COMPLEX WITH PYRIDOXAL PHOSPHATE AND SYNTHETIC INHIBITOR;CATALYTIC ACTIVITY;FUNCTION;COFACTOR;SUBUNIT;BIOPHYSICOCHEMICAL PROPERTIES
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