Protein name:
E3 ubiquitin-protein ligase SIAH2 ;
Alternative:
Seven in absentia homolog 2 (Siah-2) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer. Interacts with VAV1, without mediating its ubiquitin-mediated degradation. Probable component of some large E3 complex possibly composed of UBE2D1, SIAH2, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with UBE2I and UBE2E2. Interacts with PEG10, which may inhibit its activity. Interacts with PEG3 and EGLN2 (By similarity). Interacts with SNCAIP.
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Promotes monoubiquitination of SNCA (By similarity). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not.
Subcellular Location:
Cytoplasm
Nucleus
Predominantly cytoplasmic (Probable). Partially nuclear.
Protein Attributes:
50:
MSRPSSTGPS | ANKPCSKQPP | PPQTPHAPSP | AAPPAAATIS | AAGPGSSAVP |
100:
AAAAVISGPG | AGGGAGPVSP | QHHELTSLFE | CPVCFDYVLP | PILQCQAGHL |
150:
VCNQCRQKLS | CCPTCRGALT | PSIRNLAMEK | VASAVLFPCK | YATTGCSLTL |
200:
HHTEKPEHED | ICEYRPYSCP | CPGASCKWQG | SLEAVMSHLM | HAHKSITTLQ |
250:
GEDIVFLATD | INLPGAVDWV | MMQSCFGHHF | MLVLEKQEKY | EGHQQFFAIV |
300:
LLIGTRKQAE | NFAYRLELNG | NRRRLTWEAT | PRSIHDGVAA | AIMNSDCLVF |
325:
DTAIAHLFAD | NGNLGINVTI | STCCQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Rat E3 ubiquitin-protein ligase SIAH2
ELISA Kit for Rat E3 ubiquitin-protein ligase SIAH2
ELISA Kit for Rat E3 ubiquitin-protein ligase SIAH2
CLIA Kit for Rat E3 ubiquitin-protein ligase SIAH2
CLIA Kit for Rat E3 ubiquitin-protein ligase SIAH2
CLIA Kit for Rat E3 ubiquitin-protein ligase SIAH2
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase SIAH2
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase SIAH2
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase SIAH2
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase SIAH2
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase SIAH2
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase SIAH2
Protein for Rat E3 ubiquitin-protein ligase SIAH2
Protein for Rat E3 ubiquitin-protein ligase SIAH2
Protein for Rat E3 ubiquitin-protein ligase SIAH2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 71-325;FUNCTION IN SYP DEGRADATION;INTERACTION WITH UBE2E2
strain :
Sprague-Dawley .
3.
"Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease."
Liani E.
,
Eyal A.
,
Avraham E.
,
Shemer R.
,
Szargel R.
,
Berg D.
,
Bornemann A.
,
Riess O.
,
Ross C.A.
,
Rott R.
,
Engelender S.
Proc. Natl. Acad. Sci. U.S.A.101:5500-5505(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SNCAIP
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;INTERACTION WITH SNCAIP;TISSUE SPECIFICITY