Slit homolog 2 protein (Protein name
), SLIT2_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Citations (2)
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Gene name:
SLIT2(SLIL3);
Protein name:
Slit homolog 2 protein(Slit-2);
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with GREM1 (By similarity). Homodimer. Binds ROBO1 and ROBO2 with high affinity.
Function:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
Subcellular Location:
Secreted
The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;VARIANTS PRO-636 AND PHE-1277
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF 1122-1129;FUNCTION;INTERACTION WITH ROBO1 AND ROBO2;SUBCELLULAR LOCATION
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
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Cited for: X-RAY CRYSTALLOGRAPHY (3.01 ANGSTROMS) OF 504-716;DISULFIDE BONDS
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Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 271-480 IN COMPLEX WITH ROBO1;DISULFIDE BONDS
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Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 726-907;SUBUNIT;DISULFIDE BONDS;HEPARIN-BINDING
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Vaild Sequence:
