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Index > Protein center > Smad6(Gene name) > Mouse
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  • Smad6 (Gene name),
  • Mothers against decapentaplegic homolog 6 (Protein name ),  SMAD6_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Smad6(Madh6;Madh7;Msmad6);
    Protein name:
    Mothers against decapentaplegic homolog 6(MAD homolog 6;Mothers against DPP homolog 6);
    Alternative:
    SMAD family member 6(SMAD 6;Smad6);Mad homolog 7;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with STAMBP and PRKX (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members. Interacts with NEDD4L. Interacts with WWP1.
    Function:
    Binds to regulatory elements in target promoter regions (By similarity). Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Inhibits phosphorylation activity of SMAD1 induced by BMP type IB receptor and interferes with the phosphorylation of SMAD2 and the subsequent heteromerization with SMAD4.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    495
    Sequence:
    50:
    MFRSKRSGLV | RRLWRSRVVP | DREEGSGGGG | GVDEDGSLGS | RAEPAPRARE | 
    100:
    GGGCSRSEVR | SVAPRRPRDA | VGPRGAAIAG | RRRRTGGLPR | PVSESGAGAG | 
    150:
    GSPLDVAEPG | GPGWLPESDC | ETVTCCLFSE | RDAAGAPRDS | GDPQARQSPE | 
    200:
    PEEGGGPRSR | EARSRLLLLE | QELKTVTYSL | LKRLKERSLD | TLLEAVESRG | 
    250:
    GVPGGCVLVP | RADLRLGGQP | APPQLLLGRL | FRWPDLQHAV | ELKPLCGCHS | 
    300:
    FTAAADGPTV | CCNPYHFSRL | CGPESPPPPY | SRLSPPDQYK | PLDLSDSTLS | 
    350:
    YTETEATNSL | ITAPGEFSDA | SMSPDATKPS | HWCSVAYWEH | RTRVGRLYAV | 
    400:
    YDQAVSIFYD | LPQGSGFCLG | QLNLEQRSES | VRRTRSKIGF | GILLSKEPDG | 
    450:
    VWAYNRGEHP | IFVNSPTLDA | PGGRALVVRK | VPPGYSIKVF | DFERSGLLQH | 
    495:
    ADAAHGPYDP | HSVRISFAKG | WGPCYSRQFI | TSCPCWLEIL | LNNHR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MAD homolog 6
    Cat.:
    E2187h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse MAD homolog 6
    Cat.:
    E2187m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse MAD homolog 6
    Cat.:
    E2187c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MAD homolog 6
    Cat.:
    U2187c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MAD homolog 6
    Cat.:
    U2187h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MAD homolog 6
    Cat.:
    U2187m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse MAD homolog 6
    Cat.:
    P2187Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MAD homolog 6
    Cat.:
    P2187Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MAD homolog 6
    Monoclonal Antibody for Mouse MAD homolog 6
    Monoclonal Antibody for Mouse MAD homolog 6
    Monoclonal Antibody for Mouse MAD homolog 6
    Protein for Mouse MAD homolog 6
    Protein for Mouse MAD homolog 6
    Protein for Mouse MAD homolog 6

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    Precision
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    Linearity
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    References
    1. 1.
      "Smad6 inhibits signalling by the TGF-beta superfamily."
      Imamura T. , Takase M. , Nishihara A. , Oeda E. , Hanai J. , Kawabata M. , Miyazono K.
      Nature389:622-626(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lung.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-495
      strain: C57BL/6J.
      tissue: Lung.
    3. 3.
      "Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7."
      Koinuma D. , Shinozaki M. , Komuro A. , Goto K. , Saitoh M. , Hanyu A. , Ebina M. , Nukiwa T. , Miyazawa K. , Imamura T. , Miyazono K.
      EMBO J.22:6458-6470(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF111
    4. 4.
      "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)."
      Komuro A. , Imamura T. , Saitoh M. , Yoshida Y. , Yamori T. , Miyazono K. , Miyazawa K.
      Oncogene23:6914-6923(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WWP1;UBIQUITINATION
    5. 5.
      "NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor."
      Kuratomi G. , Komuro A. , Goto K. , Shinozaki M. , Miyazawa K. , Miyazono K. , Imamura T.
      Biochem. J.386:461-470(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEDD4L
    6. 6.
      "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1."
      Choi K.C. , Lee Y.S. , Lim S. , Choi H.K. , Lee C.H. , Lee E.K. , Hong S. , Kim I.H. , Kim S.J. , Park S.H.
      Nat. Immunol.7:1057-1065(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PELI1;INDUCTION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT ARG-74 AND ARG-81;MUTAGENESIS OF ARG-74
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