SMAD7 ELISA Kit for Human(Homo sapiens) | EIAab.comSMAD7 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SMAD7(Gene name) > Human

SMAD7 (Gene name),

Mothers against decapentaplegic homolog 7 (Protein name ), SMAD7_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SMAD7(MADH7;MADH8);

Protein name:

Mothers against decapentaplegic homolog 7(MAD homolog 7;Mothers against DPP homolog 7);

Alternative:

SMAD family member 7(SMAD 7;Smad7;hSMAD7);Mothers against decapentaplegic homolog 8(MAD homolog 8;Mothers against DPP homolog 8);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with WWP1 (By similarity). Interacts with COPS5. Interacts with NEDD4L. Interacts with STAMBP. Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts (via MH2 domain) with EP300. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation.

Function:

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.

Subcellular Location:

Nucleus Cytoplasm Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm.

Protein Attributes:

Sequence length:

426

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

426:

KGWGQCYTRQ | FISSCPCWLE | VIFNSR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.465087

SMR:

O15105

String:

O15105

MIM:

602932

KEGG:

hsa:4092

STRING:

9606.ENSP00000262158

Pfam:

PF03165

Uniprot:

O15105

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ELISA Kit for Human MAD homolog 7

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E0648h

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96T

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ELISA Kit for Human MAD homolog 7

Cat.:

E0648m

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Manual:

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96T

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ELISA Kit for Human MAD homolog 7

Cat.:

E0648r

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96T

CLIA Kit for Human MAD homolog 7

Cat.:

U0648m

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96T

CLIA Kit for Human MAD homolog 7

Cat.:

U0648r

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MSDS:

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Packing:

96T

CLIA Kit for Human MAD homolog 7

Cat.:

U0648h

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96T

Polyclonal Antibody for Human MAD homolog 7

Cat.:

P0648Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human MAD homolog 7

Cat.:

P0648Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MAD homolog 7

Cat.:

P0648Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human MAD homolog 7

Protein for Human MAD homolog 7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling."
Hayashi H. , Abdollah S. , Qiu Y. , Cai J. , Xu Y.-Y. , Grinnell B.W. , Richardson M.A. , Topper J.N. , Gimbrone M.A. Jr. , Wrana J.L. , Falb D.
Cell89:1165-1173(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF 409-ARG--ARG-426
tissue: Umbilical vein endothelial cell.
2.

"Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium."
Topper J.N. , Cai J. , Qui Y. , Anderson K.R. , Xu Y.-Y. , Deeds J.D. , Feeley R. , Gimeno C.J. , Woolf E.A. , Tayber O. , Mays G.G. , Sampson B.A. , Schoen F.J. , Gimbrone M.A. Jr. , Falb D.
Proc. Natl. Acad. Sci. U.S.A.94:9314-9319(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Umbilical vein endothelial cell.
3.

"Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling."
Nakao A. , Afrakhte M. , Moren A. , Nakayama T. , Christian J.L. , Heuchel R. , Itoh S. , Kawabata M. , Heldin N.-E. , Heldin C.-H. , ten Dijke P.
Nature389:631-635(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
4.

Hagiwara K. , Yang K. , McMenamin M.G. , Freeman A.H. , Bennett W.P. , Nagashima M. , Minter A.R. , Miyazono K. , Takenoshita S. , Harris C.C.
Submitted (1997-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 98-271 (ISOFORM 3)
tissue: Pulmonary artery.
6.

"DNA sequence and analysis of human chromosome 18."
Nusbaum C. , Zody M.C. , Borowsky M.L. , Kamal M. , Kodira C.D. , Taylor T.D. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Abouelleil A. , Allen N.R. , Anderson S. , Bloom T. , Bugalter B. , Butler J. , more...
Nature437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
8.

"TGF-beta signal transduction."
Massague J.
Annu. Rev. Biochem.67:753-791(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
9.

"Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells."
Verschueren K. , Huylebroeck D.
Cytokine Growth Factor Rev.10:187-199(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
10.

"Roles of pathway-specific and inhibitory Smads in activin receptor signaling."
Lebrun J.J. , Takabe K. , Chen Y. , Vale W.
Mol. Endocrinol.13:15-23(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACVR1B;FUNCTION
11.

"The Smad pathway."
Wrana J.L. , Attisano L.
Cytokine Growth Factor Rev.11:5-13(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
12.

"TGF-beta signaling by Smad proteins."
Miyazono K.
Cytokine Growth Factor Rev.11:15-22(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
13.

"Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation."
Kavsak P. , Rasmussen R.K. , Causing C.G. , Bonni S. , Zhu H. , Thomsen G.H. , Wrana J.L.
Mol. Cell6:1365-1375(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-211 AND 207-PRO--TYR-211;INTERACTION WITH SMURF2 AND TGFBR1
14.

"Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads."
Itoh F. , Asao H. , Sugamura K. , Heldin C.-H. , ten Dijke P. , Itoh S.
EMBO J.20:4132-4142(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAMBP
15.

"Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation."
Ebisawa T. , Fukuchi M. , Murakami G. , Chiba T. , Tanaka K. , Imamura T. , Miyazono K.
J. Biol. Chem.276:12477-12480(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMURF1 AND TGFBR1;PROTEASOMAL DEGRADATION
16.

"Phosphorylation regulation of the interaction between Smad7 and activin type I receptor."
Liu X. , Nagarajan R.P. , Vale W. , Chen Y.
FEBS Lett.519:93-98(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACVR1B;FUNCTION
17.

"Control of Smad7 stability by competition between acetylation and ubiquitination."
Gronroos E. , Hellman U. , Heldin C.H. , Ericsson J.
Mol. Cell10:483-493(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EP300;ACETYLATION AT LYS-64 AND LYS-70;UBIQUITINATION AT LYS-64 AND LYS-70;MUTAGENESIS OF LYS-64 AND LYS-70
18.

"Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7."
Koinuma D. , Shinozaki M. , Komuro A. , Goto K. , Saitoh M. , Hanyu A. , Ebina M. , Nukiwa T. , Miyazawa K. , Imamura T. , Miyazono K.
EMBO J.22:6458-6470(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF111;UBIQUITINATION;SUBCELLULAR LOCATION
19.

"GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor."
Shi W. , Sun C. , He B. , Xiong W. , Shi X. , Yao D. , Cao X.
J. Cell Biol.164:291-300(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPP1R15A
20.

"Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation."
Kim B.-C. , Lee H.-J. , Park S.H. , Lee S.R. , Karpova T.S. , McNally J.G. , Felici A. , Lee D.K. , Kim S.-J.
Mol. Cell. Biol.24:2251-2262(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS5
21.

"Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain."
Ogunjimi A.A. , Briant D.J. , Pece-Barbara N. , Le Roy C. , Di Guglielmo G.M. , Kavsak P. , Rasmussen R.K. , Seet B.T. , Sicheri F. , Wrana J.L.
Mol. Cell19:297-308(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMURF2
22.

"Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."
Liu W. , Rui H. , Wang J. , Lin S. , He Y. , Chen M. , Li Q. , Ye Z. , Zhang S. , Chan S.C. , Chen Y.-G. , Han J. , Lin S.-C.
EMBO J.25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AXIN1 AND AXIN2;UBIQUITINATION;SUBCELLULAR LOCATION
23.

"3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins."
Seong H.A. , Jung H. , Kim K.T. , Ha H.
J. Biol. Chem.282:12272-12289(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION BY PDPK1;INTERACTION WITH PDPK1
24.

"An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2."
Chong P.A. , Lin H. , Wrana J.L. , Forman-Kay J.D.
J. Biol. Chem.281:17069-17075(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 203-217 IN COMPLEX WITH SMURF2
25.

"A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk."
Members of the CORGI consortium , Broderick P. , Carvajal-Carmona L. , Pittman A.M. , Webb E. , Howarth K. , Rowan A. , Lubbe S. , Spain S. , Sullivan K. , Fielding S. , Jaeger E. , Vijayakrishnan J. , Kemp Z. , Gorman M. , Chandler I. , Papaemmanuil E. , Penegar S. , more...
Nat. Genet.39:1315-1317(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CRCS3

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