Smad7 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSmad7 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Smad7(Gene name) > Rat

Smad7 (Gene name),

Mothers against decapentaplegic homolog 7 (Protein name ), SMAD7_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Smad7(Madh7);

Protein name:

Mothers against decapentaplegic homolog 7(MAD homolog 7;Mothers against DPP homolog 7);

Alternative:

SMAD family member 7(SMAD 7;Smad7);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with COPS5. Interacts with STAMBP. Interacts with NEDD4L. Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation. Interacts with WWP1.

Function:

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.

Subcellular Location:

Nucleus Cytoplasm Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm.

Protein Attributes:

Sequence length:

426

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

426:

KGWGQCYTRQ | FISSCPCWLE | VIFNSR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O88406

STRING:

10116.ENSRNOP00000024831

KEGG:

rno:81516

UniGene:

Rn.29980

Pfam:

PF03165

Uniprot:

O88406

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ELISA Kit for Rat MAD homolog 7

Cat.:

E0648h

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96T

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ELISA Kit for Rat MAD homolog 7

Cat.:

E0648m

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Manual:

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96T

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ELISA Kit for Rat MAD homolog 7

Cat.:

E0648r

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MSDS:

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Packing:

96T

CLIA Kit for Rat MAD homolog 7

Cat.:

U0648m

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MSDS:

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Packing:

96T

CLIA Kit for Rat MAD homolog 7

Cat.:

U0648r

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MSDS:

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Packing:

96T

CLIA Kit for Rat MAD homolog 7

Cat.:

U0648h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat MAD homolog 7

Cat.:

P0648Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat MAD homolog 7

Cat.:

P0648Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat MAD homolog 7

Cat.:

P0648Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat MAD homolog 7

Protein for Rat MAD homolog 7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Genomic locus and promoter region of rat Smad7, an important antagonist of TGFbeta signaling."
Stopa M. , Benes V. , Ansorge W. , Gressner A.M. , Dooley S.
Mamm. Genome11:169-176(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
2.

"Regulation and actions of Smad7 in the modulation of activin, inhibin, and transforming growth factor-beta signaling in anterior pituitary cells."
Bilezikjian L.M. , Corrigan A.Z. , Blount A.L. , Chen Y. , Vale W.W.
Endocrinology142:1065-1072(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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