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Index > Protein center > SNAP25(Gene name) > Human
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  • SNAP25 (Gene name),
  • Synaptosomal-associated protein 25 (Protein name ),  SNP25_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SNAP25(SNAP);
    Protein name:
    Synaptosomal-associated protein 25(SNAP-25);
    Alternative:
    Synaptosomal-associated 25 kDa protein;Super protein(SUP);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with CENPF, TRIM9, RIMS1, SNAPIN, OTOF and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a complex containing SYT1, SV2B and syntaxin-1.
    Function:
    t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
    Subcellular Location:
    Cytoplasm perinuclear region Cell membrane Lipid-anchor Cell junction synapse synaptosome Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region.
    Protein Attributes:
    Sequence length:
    206
    Sequence:
    50:
    MAEDADMRNE | LEEMQRRADQ | LADESLESTR | RMLQLVEESK | DAGIRTLVML | 
    100:
    DEQGEQLERI | EEGMDQINKD | MKEAEKNLTD | LGKFCGLCVC | PCNKLKSSDA | 
    150:
    YKKAWGNNQD | GVVASQPARV | VDEREQMAIS | GGFIRRVTND | ARENEMDENL | 
    200:
    EQVSGIIGNL | RHMALDMGNE | IDTQNRQIDR | IMEKADSNKT | RIDEANQRAT | 
    206:
    KMLGSG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    UniGene:
    MIM:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human SNAP-25
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    E15057h
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    ELISA Kit for Human SNAP-25
    MSDS:
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    ELISA Kit for Human SNAP-25
    MSDS:
    Please sign in first.
    ELISA Kit for Human SNAP-25
    MSDS:
    Please sign in first.
    ELISA Kit for Human SNAP-25
    MSDS:
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    ELISA Kit for Human SNAP-25
    MSDS:
    Please sign in first.
    CLIA Kit for Human SNAP-25
    MSDS:
    Please sign in first.
    CLIA Kit for Human SNAP-25
    MSDS:
    Please sign in first.
    CLIA Kit for Human SNAP-25
    MSDS:
    Please sign in first.
    CLIA Kit for Human SNAP-25
    MSDS:
    Please sign in first.
    CLIA Kit for Human SNAP-25
    MSDS:
    Please sign in first.
    CLIA Kit for Human SNAP-25
    Cat.:
    U15057h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human SNAP-25
    Polyclonal Antibody for Human SNAP-25
    Polyclonal Antibody for Human SNAP-25
    Polyclonal Antibody for Human SNAP-25
    Polyclonal Antibody for Human SNAP-25
    Polyclonal Antibody for Human SNAP-25
    Monoclonal Antibody for Human SNAP-25
    Monoclonal Antibody for Human SNAP-25
    Monoclonal Antibody for Human SNAP-25
    Monoclonal Antibody for Human SNAP-25
    Monoclonal Antibody for Human SNAP-25
    Monoclonal Antibody for Human SNAP-25
    Protein for Human SNAP-25
    Protein for Human SNAP-25
    Protein for Human SNAP-25
    Protein for Human SNAP-25
    Protein for Human SNAP-25
    Protein for Human SNAP-25

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    References
    1. 1.
      "Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25."
      Bark I.C. , Wilson M.C.
      Gene139:291-292(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Fetal brain.
      tissue: Temporal cortex.
    2. 2.
      "Cloning and sequence analysis of the human SNAP25 cDNA."
      Zhao N. , Hashida H. , Takahashi N. , Sakaki Y.
      Gene145:313-314(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Frontal cortex.
    3. 3.
      "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2."
      Jagadish M.N. , Fernandez C.S. , Hewish D.R. , Macaulay S.L. , Gough K.H. , Grusovin J. , Verkuylen A. , Cosgrove L. , Alafaci A. , Frenkel M.J. , Ward C.W.
      Biochem. J.317:945-954(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
      tissue: Skeletal muscle.
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Amygdala.
      tissue: Hippocampus.
    6. 6.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    7. 7.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Eye.
    10. 10.
      "SNAP-25 is also an iron-sulfur protein."
      Huang Q. , Hong X. , Hao Q.
      FEBS Lett.582:1431-1436(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PUTATIVE IRON-SULFUR CLUSTER
    11. 11.
      "The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth."
      Ghiani C.A. , Starcevic M. , Rodriguez-Fernandez I.A. , Nazarian R. , Cheli V.T. , Chan L.N. , Malvar J.S. , de Vellis J. , Sabatti C. , Dell'Angelica E.C.
      Mol. Psychiatry15:204-215(2010)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH THE BLOC-1 COMPLEX;INTERACTION WITH BLOC1S6
    12. 12.
      "Three-dimensional structure of the complexin/SNARE complex."
      Chen X. , Tomchick D.R. , Kovrigin E. , Arac D. , Machius M. , Suedhof T.C. , Rizo J.
      Neuron33:397-409(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 11-81 AND 141-202 IN COMPLEX WITH STX1A; CPLX1 AND VAMP2;STRUCTURE BY NMR
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