Protein name:
Sorting nexin-1 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Self-assembles into a complex of approximately 300 kDa (By similarity). Interacts with HGS (By similarity). Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with SNX6.
Function:
May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Subcellular Location:
Endosome membrane
Peripheral membrane protein
Cytoplasmic side
Golgi apparatus
trans-Golgi network membrane
Peripheral membrane protein
Cytoplasmic side
Early endosome membrane
Peripheral membrane protein
Cytoplasmic side
Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIn.
Protein Attributes:
50:
MASGGGGCSA | SERLPPPFPG | LEPESEGAAG | GSEPEAGDSD | TEGEDIFTGA |
100:
AVVSKHQSPK | ITTSLLPINN | GSKENGIHEE | QDQEPQDLFA | DATVELSLDS |
150:
TQNNQKKVLA | KTLISLPPQE | ATNSSKPQPT | YEELEEEEQE | DQFDLTVGIT |
200:
DPEKIGDGMN | AYVAYKVTTQ | TSLPLFRSKQ | FAVKRRFSDF | LGLYEKLSEK |
250:
HSQNGFIVPP | PPEKSLIGMT | KVKVGKEDSS | SAEFLEKRRA | ALERYLQRIV |
300:
NHPTMLQDPD | VREFLEKEEL | PRAVGTQTLS | GAGLLKMFNK | ATDAVSKMTI |
350:
KMNESDIWFE | EKLQEVECEE | QRLRKLHAVV | ETLVNHRKEL | ALNTAQFAKS |
400:
LAMLGSSEDN | TALSRALSQL | AEVEEKIEQL | HQEQANNDFF | LLAELLSDYI |
450:
RLLAIVRAAF | DQRMKTWQRW | QDAQATLQKK | REAEARLLWA | NKPDKLQQAK |
500:
DEILEWESRV | TQYERDFERI | STVVRKEVIR | FEKEKSKDFK | NHVIKYLETL |
522:
LYSQQQLAKY | WEAFLPEAKA | IS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Rat
Mouse
ELISA Kit for Human Sorting nexin-1
ELISA Kit for Human Sorting nexin-1
ELISA Kit for Human Sorting nexin-1
ELISA Kit for Human Sorting nexin-1
CLIA Kit for Human Sorting nexin-1
CLIA Kit for Human Sorting nexin-1
CLIA Kit for Human Sorting nexin-1
CLIA Kit for Human Sorting nexin-1
Polyclonal Antibody for Human Sorting nexin-1
Polyclonal Antibody for Human Sorting nexin-1
Polyclonal Antibody for Human Sorting nexin-1
Polyclonal Antibody for Human Sorting nexin-1
Monoclonal Antibody for Human Sorting nexin-1
Monoclonal Antibody for Human Sorting nexin-1
Monoclonal Antibody for Human Sorting nexin-1
Monoclonal Antibody for Human Sorting nexin-1
Protein for Human Sorting nexin-1
Protein for Human Sorting nexin-1
Protein for Human Sorting nexin-1
Protein for Human Sorting nexin-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING;INTERACTION WITH VPS26A; VPS29; VPS35 AND SNX2
3.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue :
Placenta .
tissue :
Testis .
5.
"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C.
,
Garber M.
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Young S.K.
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more...
Nature440:671-675(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Muscle .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH VPS26A;SUBUNIT
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-214;INTERACTION WITH PHOSPHATIDYLINOSITIDES
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;INTERACTION WITH SNX2
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-214 AND 429-LYS--ARG-431
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;SUBUNIT
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; SER-39 AND SER-188;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SNX6
19.
"The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network."
Wassmer T.
,
Attar N.
,
Harterink M.
,
van Weering J.R.
,
Traer C.J.
,
Oakley J.
,
Goud B.
,
Stephens D.J.
,
Verkade P.
,
Korswagen H.C.
,
Cullen P.J.
Dev. Cell17:110-122(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT;INTERACTION WITH SNX5; SNX6; VPS26A; VPS29; VPS35 AND DENND5A
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DOMAIN
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-237;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
"Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes."
Popoff V.
,
Mardones G.A.
,
Bai S.K.
,
Chambon V.
,
Tenza D.
,
Burgos P.V.
,
Shi A.
,
Benaroch P.
,
Urbe S.
,
Lamaze C.
,
Grant B.D.
,
Raposo G.
,
Johannes L.
Traffic10:1868-1880(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DNAJC13;SUBCELLULAR LOCATION
24.
"Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking."
Kim E.
,
Lee Y.
,
Lee H.J.
,
Kim J.S.
,
Song B.S.
,
Huh J.W.
,
Lee S.R.
,
Kim S.U.
,
Kim S.H.
,
Hong Y.
,
Shim I.
,
Chang K.T.
Biochem. Biophys. Res. Commun.403:167-171(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
25.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH KALRN AND RHOG;SUBCELLULAR LOCATION
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
29.
"Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice."
Villar V.A.
,
Jones J.E.
,
Armando I.
,
Asico L.D.
,
Escano C.S. Jr.
,
Lee H.
,
Wang X.
,
Yang Y.
,
Pascua-Crusan A.M.
,
Palmes-Saloma C.P.
,
Felder R.A.
,
Jose P.A.
J. Biol. Chem.288:152-163(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH DRD5
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 142-269;SUBCELLULAR LOCATION
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 301-522;FUNCTION;INTERACTION WITH SNX5; SNX6 AND SNX32;SELF-ASSOCIATION;SUBUNIT;DOMAIN;MUTAGENESIS OF 287-MET-PHE-288; LYS-442 AND LYS-445