Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > SNX9(Gene name) > Human
  • Add your favorite
  • SNX9 (Gene name),
  • Sorting nexin-9 (Protein name ),  SNX9_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    SNX9(SH3PX1;SH3PXD3A);
    Protein name:
    Sorting nexin-9;
    Alternative:
    SH3 and PX domain-containing protein 3A;SH3 and PX domain-containing protein 1(Protein SDP1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer, and homooligomer. Heterodimer with SNX18. Interacts with ITCH. Interacts (via SH3 domain) with TNK2, WASL and ARP3. Identified in a complex with TNK2 and clathrin heavy chains. Identified in a complex with the AP-2 complex, clathrin and DNM2. Interacts (via SH3 domain) with DNM1 and DNM2. Identified in an oligomeric complex containing DNM1 and SNX9.
    Function:
    May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
    Subcellular Location:
    Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic vesicle clathrin-coated vesicle Golgi apparatus trans-Golgi network Cell projection ruffle Cytoplasm Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
    Protein Attributes:
    Sequence length:
    595
    Sequence:
    50:
    MATKARVMYD | FAAEPGNNEL | TVNEGEIITI | TNPDVGGGWL | EGRNIKGERG | 
    100:
    LVPTDYVEIL | PSDGKDQFSC | GNSVADQAFL | DSLSASTAQA | SSSAASNNHQ | 
    150:
    VGSGNDPWSA | WSASKSGNWE | SSEGWGAQPE | GAGAQRNTNT | PNNWDTAFGH | 
    200:
    PQAYQGPATG | DDDDWDEDWD | GPKSSSYFKD | SESADAGGAQ | RGNSRASSSS | 
    250:
    MKIPLNKFPG | FAKPGTEQYL | LAKQLAKPKE | KIPIIVGDYG | PMWVYPTSTF | 
    300:
    DCVVADPRKG | SKMYGLKSYI | EYQLTPTNTN | RSVNHRYKHF | DWLYERLLVK | 
    350:
    FGSAIPIPSL | PDKQVTGRFE | EEFIKMRMER | LQAWMTRMCR | HPVISESEVF | 
    400:
    QQFLNFRDEK | EWKTGKRKAE | RDELAGVMIF | STMEPEAPDL | DLVEIEQKCE | 
    450:
    AVGKFTKAMD | DGVKELLTVG | QEHWKRCTGP | LPKEYQKIGK | ALQSLATVFS | 
    500:
    SSGYQGETDL | NDAITEAGKT | YEEIASLVAE | QPKKDLHFLM | ECNHEYKGFL | 
    550:
    GCFPDIIGTH | KGAIEKVKES | DKLVATSKIT | LQDKQNMVKR | VSIMSYALQA | 
    595:
    EMNHFHSNRI | YDYNSVIRLY | LEQQVQFYET | IAEKLRQALS | RFPVM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    String:
    UniGene:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Sorting nexin-9
    Cat.:
    E11356h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Sorting nexin-9
    Cat.:
    E11356m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Sorting nexin-9
    Cat.:
    U11356h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Sorting nexin-9
    Cat.:
    U11356m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Sorting nexin-9
    Cat.:
    P11356Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Sorting nexin-9
    Monoclonal Antibody for Human Sorting nexin-9
    Monoclonal Antibody for Human Sorting nexin-9
    Protein for Human Sorting nexin-9
    Protein for Human Sorting nexin-9

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "A large family of endosome-localized proteins related to sorting nexin 1."
      Teasdale R.D. , Loci D. , Houghton F. , Karlsson L. , Gleeson P.A.
      Biochem. J.358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."
      Howard L. , Nelson K.K. , Maciewicz R.A. , Blobel C.P.
      J. Biol. Chem.274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH ADAM9 AND ADAM15;TISSUE SPECIFICITY
    3. 3.
      "Identification of differentially expressed genes in matched prostate cancer and normal epithelial cell lines."
      Zhang J.S. , Smith D.I.
      Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
      tissue: Skin.
    6. 6.
      "Human SDP1."
      Ramanathan G. , Subramaniam V.N. , Hong W.
      Submitted (1998-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 201-595
    7. 7.
      "The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation."
      Lin Q. , Lo C.G. , Cerione R.A. , Yang W.
      J. Biol. Chem.277:10134-10138(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TNK2;IDENTIFICATION IN A COMPLEX WITH TNK2 AND CLATHRIN HEAVY CHAIN;TYROSINE PHOSPHORYLATION
    8. 8.
      "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components."
      Lundmark R. , Carlsson S.R.
      J. Biol. Chem.278:46772-46781(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DNM2 AND THE AP-2 COMPLEX;IDENTIFICATION IN A COMPLEX WITH THE AP-2 COMPLEX; CLATHRIN AND DNM2;SUBCELLULAR LOCATION
    9. 9.
      "SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1."
      Yeow-Fong L. , Lim L. , Manser E.
      FEBS Lett.579:5040-5048(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNK2;SUBCELLULAR LOCATION
    10. 10.
      "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis."
      Soulet F. , Yarar D. , Leonard M. , Schmid S.L.
      Mol. Biol. Cell16:2058-2067(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH DNM1 AND DNM2
    11. 11.
      "Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2."
      Childress C. , Lin Q. , Yang W.
      Biochem. J.394:693-698(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION;TYROSINE PHOSPHORYLATION
    12. 12.
      "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis."
      Yarar D. , Waterman-Storer C.M. , Schmid S.L.
      Dev. Cell13:43-56(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH WASL;SUBCELLULAR LOCATION;SUBUNIT;PHOSPHATIDYLINOSITOL 4,5-BISPHOSPATE BINDING
    13. 13.
      "SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2."
      Shin N. , Ahn N. , Chang-Ileto B. , Park J. , Takei K. , Ahn S.G. , Kim S.A. , Di Paolo G. , Chang S.
      J. Cell Sci.121:1252-1263(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH ARP3; WASL AND DNM2
    14. 14.
      "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M. , Lettau M. , Janssen O.
      BMC Immunol.10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FASLG
    15. 15.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-288;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain."
      Baumann C. , Lindholm C.K. , Rimoldi D. , Levy F.
      FEBS J.277:2803-2814(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITCH;UBIQUITINATION BY ITCH
    17. 17.
      "SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane."
      Park J. , Kim Y. , Lee S. , Park J.J. , Park Z.Y. , Sun W. , Kim H. , Chang S.
      J. Cell Sci.123:1742-1750(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;SUBCELLULAR LOCATION
    18. 18.
      "The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins."
      Wang J.T. , Kerr M.C. , Karunaratne S. , Jeanes A. , Yap A.S. , Teasdale R.D.
      PLoS ONE5:E13763-E13763(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis."
      Ma M.P. , Chircop M.
      J. Cell Sci.125:4372-4382(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    21. 21.
      "The PX-BAR membrane-remodeling unit of sorting nexin 9."
      Pylypenko O. , Lundmark R. , Rasmuson E. , Carlsson S.R. , Rak A.
      EMBO J.26:4788-4800(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 204-595 IN COMPLEX WITH PHOSPHATIDYLINOSITOL 3-PHOSPHATE;FUNCTION;SUBUNIT;DOMAIN;SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-287; LYS-313; LYS-363; 366-LYS-ARG-367; LYS-522 AND LYS-528
    22. 22.
      "Structure and plasticity of Endophilin and Sorting Nexin 9."
      Wang Q. , Kaan H.Y. , Hooda R.N. , Goh S.L. , Sondermann H.
      Structure16:1574-1587(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 230-595;SUBUNIT
    23. 23.
      "Mechanism of aldolase control of sorting nexin 9 function in endocytosis."
      Rangarajan E.S. , Park H. , Fortin E. , Sygusch J. , Izard T.
      J. Biol. Chem.285:11983-11990(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 152-182 IN COMPLEX WITH ALDOA
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
    Top Searches
    Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Tumor necrosis Asprosin TRAP1A Alpha
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter