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Index > Protein center > SERPINB6(Gene name) > Human
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  • SERPINB6 (Gene name),
  • Serpin B6 (Protein name ),  SPB6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SERPINB6(PI6;PTI);
    Protein name:
    Serpin B6;
    Alternative:
    Peptidase inhibitor 6(PI-6);Cytoplasmic antiproteinase(CAP);Placental thrombin inhibitor;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a complex with the monomeric form of beta-tryptase.
    Function:
    May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    376
    Sequence:
    50:
    MDVLAEANGT | FALNLLKTLG | KDNSKNVFFS | PMSMSCALAM | VYMGAKGNTA | 
    100:
    AQMAQILSFN | KSGGGGDIHQ | GFQSLLTEVN | KTGTQYLLRM | ANRLFGEKSC | 
    150:
    DFLSSFRDSC | QKFYQAEMEE | LDFISAVEKS | RKHINTWVAE | KTEGKIAELL | 
    200:
    SPGSVDPLTR | LVLVNAVYFR | GNWDEQFDKE | NTEERLFKVS | KNEEKPVQMM | 
    250:
    FKQSTFKKTY | IGEIFTQILV | LPYVGKELNM | IIMLPDETTD | LRTVEKELTY | 
    300:
    EKFVEWTRLD | MMDEEEVEVS | LPRFKLEESY | DMESVLRNLG | MTDAFELGKA | 
    350:
    DFSGMSQTDL | SLSKVVHKSF | VEVNEEGTEA | AAATAAIMMM | RCARFVPRFC | 
    376:
    ADHPFLFFIQ | HSKTNGILFC | GRFSSP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
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    ELISA Kit for Human Serpin B6
    MSDS:
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    ELISA Kit for Human Serpin B6
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    E11772h
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    96T
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    ELISA Kit for Human Serpin B6
    Cat.:
    E11772m
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    Packing:
    96T
    CLIA Kit for Human Serpin B6
    Cat.:
    U11772m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serpin B6
    Cat.:
    U11772h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Serpin B6
    MSDS:
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    Polyclonal Antibody for Human Serpin B6
    Polyclonal Antibody for Human Serpin B6
    Polyclonal Antibody for Human Serpin B6
    Cat.:
    P11772Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Serpin B6
    Monoclonal Antibody for Human Serpin B6
    Monoclonal Antibody for Human Serpin B6
    Protein for Human Serpin B6
    Protein for Human Serpin B6
    Protein for Human Serpin B6

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor."
      Coughlin P. , Sun J. , Cerruti L. , Salem H.H. , Bird P.
      Proc. Natl. Acad. Sci. U.S.A.90:9417-9421(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT VAL-90;FUNCTION
      tissue: Placenta.
    2. 2.
      "Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases."
      Morgenstern K.A. , Sprecher C.A. , Holth L. , Foster D. , Grant F.J. , Ching A. , Kisiel W.
      Biochemistry33:3432-3441(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 67-73 AND 144-149;VARIANT VAL-90;FUNCTION
      tissue: Placenta.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-90
      tissue: Testis.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-90
      tissue: Small intestine.
    5. 5.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Chondrosarcoma.
      tissue: Colon.
    8. 8.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-372
      tissue: Brain.
    9. 9.
      "Identification and purification of a novel serine proteinase inhibitor."
      Coughlin P.B. , Tetaz T. , Salem H.H.
      J. Biol. Chem.268:9541-9547(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 47-60; 63-81 AND 91-98;SUBCELLULAR LOCATION
      tissue: Leukemia.
    10. 10.
      "The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G."
      Scott F.L. , Hirst C.E. , Sun J. , Bird C.H. , Bottomley S.P. , Bird P.I.
      Blood93:2089-2097(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."
      Strik M.C. , Wolbink A. , Wouters D. , Bladergroen B.A. , Verlaan A.R. , van Houdt I.S. , Hijlkema S. , Hack C.E. , Kummer J.A.
      Blood103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;COMPLEX FORMATION WITH BETA-TRYPTASE
    12. 12.
      "SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."
      Scott F.L. , Sun J. , Whisstock J.C. , Kato K. , Bird P.I.
      J. Biochem.142:435-442(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DFNB91;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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