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Index > Protein center > SPHK2(Gene name) > Human
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  • SPHK2 (Gene name),
  • Sphingosine kinase 2 (Protein name ),  SPHK2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SPHK2;
    Protein name:
    Sphingosine kinase 2(SK 2;SPK 2);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.
    Subcellular Location:
    Isoform 2 Lysosome membrane
    Protein Attributes:
    Sequence length:
    654
    Sequence:
    50:
    MNGHLEAEEQ | QDQRPDQELT | GSWGHGPRST | LVRAKAMAPP | PPPLAASTPL | 
    100:
    LHGEFGSYPA | RGPRFALTLT | SQALHIQRLR | PKPEARPRGG | LVPLAEVSGC | 
    150:
    CTLRSRSPSD | SAAYFCIYTY | PRGRRGARRR | ATRTFRADGA | ATYEENRAEA | 
    200:
    QRWATALTCL | LRGLPLPGDG | EITPDLLPRP | PRLLLLVNPF | GGRGLAWQWC | 
    250:
    KNHVLPMISE | AGLSFNLIQT | ERQNHARELV | QGLSLSEWDG | IVTVSGDGLL | 
    300:
    HEVLNGLLDR | PDWEEAVKMP | VGILPCGSGN | ALAGAVNQHG | GFEPALGLDL | 
    350:
    LLNCSLLLCR | GGGHPLDLLS | VTLASGSRCF | SFLSVAWGFV | SDVDIQSERF | 
    400:
    RALGSARFTL | GTVLGLATLH | TYRGRLSYLP | ATVEPASPTP | AHSLPRAKSE | 
    450:
    LTLTPDPAPP | MAHSPLHRSV | SDLPLPLPQP | ALASPGSPEP | LPILSLNGGG | 
    500:
    PELAGDWGGA | GDAPLSPDPL | LSSPPGSPKA | ALHSPVSEGA | PVIPPSSGLP | 
    550:
    LPTPDARVGA | STCGPPDHLL | PPLGTPLPPD | WVTLEGDFVL | MLAISPSHLG | 
    600:
    ADLVAAPHAR | FDDGLVHLCW | VRSGISRAAL | LRLFLAMERG | SHFSLGCPQL | 
    650:
    GYAAARAFRL | EPLTPRGVLT | VDGEQVEYGP | LQAQMHPGIG | TLLTGPPGCP | 
    654:
    GREP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    SMR:
    Pfam:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human SK 2
    Cat.:
    E0329m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human SK 2
    Cat.:
    E0329h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SK 2
    Cat.:
    U0329h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SK 2
    Cat.:
    U0329m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human SK 2
    Cat.:
    P0329Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SK 2
    Cat.:
    P0329Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human SK 2
    Monoclonal Antibody for Human SK 2
    Protein for Human SK 2
    Protein for Human SK 2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform."
      Liu H. , Sugiura M. , Nava V.E. , Edsall L.C. , Kono K. , Poulton S. , Milstien S. , Kohama T. , Spiegel S.
      J. Biol. Chem.275:19513-19520(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);CATALYTIC ACTIVITY;SUBSTRATE SPECIFICITY;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
    2. 2.
      "Variant of human sphingosine kinase-2 (SPHK2)."
      Alemany R. , Ruemenapp U. , van Koppen C.J. , Danneberg K. , Meyer zu Heringdorf D. , Jakobs K.H.
      Submitted (2006-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-354 (ISOFORM 3)
      tissue: Carcinoma.
      tissue: Prostate.
    5. 5.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Eye.
      tissue: Lymph.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Placenta.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "A lipid binding domain in sphingosine kinase 2."
      Don A.S. , Rosen H.
      Biochem. Biophys. Res. Commun.380:87-92(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;ENZYME REGULATION;REGION
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