Sorbin and SH3 domain-containing protein 1 (Protein name
), SRBS1_HUMAN from NCBI database.
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Gene name:
SORBS1(KIAA0894;KIAA1296;SH3D5);
Protein name:
Sorbin and SH3 domain-containing protein 1;
Alternative:
SH3 domain protein 5;Ponsin;c-Cbl-associated protein(CAP);SH3P12;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with the long isoform of MLLT4/afadin and with VCL. MLLT4 and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/p125FAK and flotillin. Interacts (via SH3 domain 2) with PXN.
Function:
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Subcellular Location:
Cell junction
adherens junction
Cell membrane
Cytoplasm
cytoskeleton
Cell junction
focal adhesion
Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4);TISSUE SPECIFICITY;INTERACTION WITH ABL1 AND INSULIN RECEPTOR;VARIANT PRO-61
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8);SUBCELLULAR LOCATION;INTERACTION WITH SCA7;VARIANT PRO-61
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);VARIANTS PRO-61; TRP-74 AND ALA-237
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6);INTERACTION WITH INPPL1;VARIANT PRO-61
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11);INTERACTION WITH PXN;X-RAY CRYSTALLOGRAPHY (0.83 ANGSTROMS) OF 870-930 IN COMPLEX WITH PXN PEPTIDE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANT PRO-61
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9);VARIANT PRO-61
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10);VARIANT PRO-61
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 9);VARIANT PRO-61
"A Fas-ligand associated factor 2, FLAF2, potentiates Fas-ligand stability." Hachiya T.
,
Kobayasi A.
,
Touji S.
,
Tamai K.
Submitted (1996-09) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 752-888
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-89; SER-472; SER-665; THR-862 AND SER-945;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-478 AND SER-735 (ISOFORM 10);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1213 (ISOFORM 12);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346 AND SER-603 (ISOFORM 4);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-923 (ISOFORM 5);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-765 (ISOFORM 6);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469 (ISOFORM 7);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-730 (ISOFORM 8);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387 AND SER-700 (ISOFORM 9);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 870-930
17.
"Solution structure of SH3 domains of human Sorbin and SH3 domain-containing protein 1." RIKEN structural genomics initiative (RSGI)
Submitted (2009-02) to the PDB data bank
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Cited for: STRUCTURE BY NMR OF 796-926