Protein name:
Serum response factor (SRF) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 (By similarity). Forms a nuclear ternary complex with MKL1 and SCAI.
Function:
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MLPTQAGAAA | ALGRGSALGG | SLNRTPTGRP | GGGGGTRGAN | GGRVPGNGAG |
100:
LGPGRLEREA | AAAAATTPAP | TAGALYSGSE | GDSESGEEEE | LGAERRGLKR |
150:
SLSEMEIGMV | VGGPEASAAA | TGGYGPVSGA | VSGAKPGKKT | RGRVKIKMEF |
200:
IDNKLRRYTT | FSKRKTGIMK | KAYELSTLTG | TQVLLLVASE | TGHVYTFATR |
250:
KLQPMITSET | GKALIQTCLN | SPDSPPRSDP | TTDQRMSATG | FEETDLTYQV |
300:
SESDSSGETK | DTLKPAFTVT | NLPGTTSTIQ | TAPSTSTTMQ | VSSGPSFPIT |
350:
NYLAPVSASV | SPSAVSSANG | TVLKSTGSGP | VSSGGLMQLP | TSFTLMPGGA |
400:
VAQQVPVQAI | QVHQAPQQAS | PSRDSSTDLT | QTSSSGTVTL | PATIMTSSVP |
450:
TTVGGHMMYP | SPHAVMYAPT | SGLGDGSLTV | LNAFSQAPST | MQVSHSQVQE |
500:
PGGVPQVFLT | ASSGTVQIPV | SAVQLHQMAV | IGQQAGSSSN | LTELQVVNLD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Polyclonal Antibody for Human SRF
Polyclonal Antibody for Human SRF
Polyclonal Antibody for Human SRF
Monoclonal Antibody for Human SRF
Monoclonal Antibody for Human SRF
Monoclonal Antibody for Human SRF
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
tissue :
Lymph .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 210-221 AND 253-264;PHOSPHORYLATION AT SER-253
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-77; SER-79; SER-83; SER-85 AND SER-103
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT SER-277; SER-307; SER-309; SER-316 AND SER-383
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-435 AND SER-446
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MLLT7
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH LPXN
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-79; SER-83; SER-85 AND SER-224;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MKL1 AND SCAI;SUBCELLULAR LOCATION
14.
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Sci. Signal.3:RA3-RA3(2010)
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 132-223