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Index > Protein center > SRF(Gene name) > Human
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  • SRF (Gene name),
  • Serum response factor (Protein name ),  SRF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SRF;
    Protein name:
    Serum response factor(SRF);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1 (By similarity). Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 (By similarity). Forms a nuclear ternary complex with MKL1 and SCAI.
    Function:
    SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    508
    Sequence:
    50:
    MLPTQAGAAA | ALGRGSALGG | SLNRTPTGRP | GGGGGTRGAN | GGRVPGNGAG | 
    100:
    LGPGRLEREA | AAAAATTPAP | TAGALYSGSE | GDSESGEEEE | LGAERRGLKR | 
    150:
    SLSEMEIGMV | VGGPEASAAA | TGGYGPVSGA | VSGAKPGKKT | RGRVKIKMEF | 
    200:
    IDNKLRRYTT | FSKRKTGIMK | KAYELSTLTG | TQVLLLVASE | TGHVYTFATR | 
    250:
    KLQPMITSET | GKALIQTCLN | SPDSPPRSDP | TTDQRMSATG | FEETDLTYQV | 
    300:
    SESDSSGETK | DTLKPAFTVT | NLPGTTSTIQ | TAPSTSTTMQ | VSSGPSFPIT | 
    350:
    NYLAPVSASV | SPSAVSSANG | TVLKSTGSGP | VSSGGLMQLP | TSFTLMPGGA | 
    400:
    VAQQVPVQAI | QVHQAPQQAS | PSRDSSTDLT | QTSSSGTVTL | PATIMTSSVP | 
    450:
    TTVGGHMMYP | SPHAVMYAPT | SGLGDGSLTV | LNAFSQAPST | MQVSHSQVQE | 
    500:
    PGGVPQVFLT | ASSGTVQIPV | SAVQLHQMAV | IGQQAGSSSN | LTELQVVNLD | 
    508:
    TAHSTKSE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    KEGG:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human SRF
    Cat.:
    E6270h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human SRF
    MSDS:
    Please sign in first.
    ELISA Kit for Human SRF
    Cat.:
    E6270m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SRF
    MSDS:
    Please sign in first.
    CLIA Kit for Human SRF
    Cat.:
    U6270h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human SRF
    Cat.:
    U6270m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human SRF
    Cat.:
    P6270Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SRF
    Polyclonal Antibody for Human SRF
    Cat.:
    P6270Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human SRF
    Monoclonal Antibody for Human SRF
    Monoclonal Antibody for Human SRF
    Protein for Human SRF
    Protein for Human SRF
    Protein for Human SRF

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element."
      Norman C. , Runswick M. , Pollock R. , Treisman R.
      Cell55:989-1003(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
    2. 2.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
      tissue: Lymph.
    5. 5.
      "C-terminal phosphorylation of the serum-response factor."
      Janknecht R. , Ernst W.H. , Houthaeve T. , Nordheim A.
      Eur. J. Biochem.216:469-475(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 210-221 AND 253-264;PHOSPHORYLATION AT SER-253
    6. 6.
      "Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties."
      Janknecht R. , Hipskind R.A. , Houthaeve T. , Nordheim A. , Stunnenberg H.G.
      EMBO J.11:1045-1054(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-77; SER-79; SER-83; SER-85 AND SER-103
    7. 7.
      "Localization of O-GlcNAc modification on the serum response transcription factor."
      Reason A.J. , Morris H.R. , Panico M. , Marais R. , Treisman R.H. , Haltiwanger R.S. , Hart G.W. , Kelly W.G. , Dell A.
      J. Biol. Chem.267:16911-16921(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-277; SER-307; SER-309; SER-316 AND SER-383
    8. 8.
      "The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites."
      Liu S.-H. , Ma J.-T. , Yueh A.Y. , Lees-Miller S.P. , Anderson C.W. , Ng S.-Y.
      J. Biol. Chem.268:21147-21154(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-435 AND SER-446
    9. 9.
      "Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin."
      Liu Z.-P. , Wang Z. , Yanagisawa H. , Olson E.N.
      Dev. Cell9:261-270(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MLLT7
    10. 10.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription."
      Sundberg-Smith L.J. , DiMichele L.A. , Sayers R.L. , Mack C.P. , Taylor J.M.
      Circ. Res.102:1502-1511(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LPXN
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-79; SER-83; SER-85 AND SER-224;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin."
      Brandt D.T. , Baarlink C. , Kitzing T.M. , Kremmer E. , Ivaska J. , Nollau P. , Grosse R.
      Nat. Cell Biol.11:557-568(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MKL1 AND SCAI;SUBCELLULAR LOCATION
    14. 14.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Structure of serum response factor core bound to DNA."
      Pellegrini L. , Tan S. , Richmond T.J.
      Nature376:490-498(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 132-223
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