SRGN ELISA Kit for Human(Homo sapiens) | EIAab.comSRGN ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SRGN(Gene name) > Human

SRGN (Gene name),

Serglycin (Protein name ), SRGN_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SRGN(PRG;PRG1);

Protein name:

Serglycin;

Alternative:

Platelet proteoglycan core protein(P.PG);Hematopoetic proteoglycan core protein;Secretory granule proteoglycan core protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds to activated CD44 and to GZMB.

Function:

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.

Subcellular Location:

Cytoplasmic granule Secreted extracellular space Golgi apparatus Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.

Protein Attributes:

Sequence length:

158

Sequence:

50:

100:

150:

158:

GLEEDFML

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.1908

Pfam:

PF04360

KEGG:

hsa:5552

MIM:

177040

STRING:

9606.ENSP00000242465

String:

P10124

Uniprot:

P10124

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ELISA Kit for Human Serglycin

Cat.:

E1072h

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96T

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ELISA Kit for Human Serglycin

Cat.:

E1072m

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96T

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ELISA Kit for Human Serglycin

Cat.:

E1072r

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96T

CLIA Kit for Human Serglycin

Cat.:

U1072h

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96T

CLIA Kit for Human Serglycin

Cat.:

U1072r

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96T

CLIA Kit for Human Serglycin

Cat.:

U1072m

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96T

Polyclonal Antibody for Human Serglycin

Cat.:

P1072Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Serglycin

Cat.:

P1072Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Serglycin

Cat.:

P1072Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Serglycin

Protein for Human Serglycin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells."
Stevens R.L. , Avraham S. , Gartner M.C. , Bruns G.A.P. , Austen K.F. , Weis J.H.
J. Biol. Chem.263:7287-7291(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLN-31
2.

"Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein."
Stellrecht C.M. , Saunders G.F.
Nucleic Acids Res.17:7523-7523(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLN-31
3.

"Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product."
Nicodemus C.F. , Avraham S. , Austen K.F. , Purdy S. , Jablonski J. , Stevens R.L.
J. Biol. Chem.265:5889-5896(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLN-31
4.

"The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells."
Humphries D.E. , Nicodemus C.F. , Schiller V. , Stevens R.L.
J. Biol. Chem.267:13558-13563(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLN-31
6.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLN-31
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLN-31
tissue: Lung.
9.

"Complete amino acid sequence of a human platelet proteoglycan."
Alliel P.M. , Perin J.-P. , Maillet P. , Bonnet F. , Rosa J.-P. , Jolles P.
FEBS Lett.236:123-126(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-158;NUCLEOTIDE SEQUENCE [MRNA] OF 34-158;GLYCOSYLATION AT SER-94 AND SER-96
10.

"Characterization and N-terminal sequence of human platelet proteoglycan."
Perin J.-P. , Bonnet F. , Maillet P. , Jolles P.
Biochem. J.255:1007-1013(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-93
11.

"Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells."
Schick B.P. , Gradowski J.F. , San Antonio J.D.
Blood97:449-458(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
12.

"Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation."
Metkar S.S. , Wang B. , Aguilar-Santelises M. , Raja S.M. , Uhlin-Hansen L. , Podack E. , Trapani J.A. , Froelich C.J.
Immunity16:417-428(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GZMB
13.

"Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin."
Raja S.M. , Wang B. , Dantuluri M. , Desai U.R. , Demeler B. , Spiegel K. , Metkar S.S. , Froelich C.J.
J. Biol. Chem.277:49523-49530(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GZMB
14.

"Localization of serglycin in human neutrophil granulocytes and their precursors."
Niemann C.U. , Cowland J.B. , Klausen P. , Askaa J. , Calafat J. , Borregaard N.
J. Leukoc. Biol.76:406-415(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
15.

"Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells."
Zernichow L. , Dalen K.T. , Prydz K. , Winberg J.-O. , Kolset S.O.
FEBS J.273:536-547(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro."
Theocharis A.D. , Seidel C. , Borset M. , Dobra K. , Baykov V. , Labropoulou V. , Kanakis I. , Dalas E. , Karamanos N.K. , Sundan A. , Hjerpe A.
J. Biol. Chem.281:35116-35128(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION

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