Signal transducer and activator of transcription 5B (Protein name
), STA5B_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Gene name:
STAT5B;
Protein name:
Signal transducer and activator of transcription 5B;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.
Function:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.
Subcellular Location:
Cytoplasm
Nucleus
Translocated into the nucleus in response to phosphorylation.
Polyclonal Antibody for Human Signal transducer and activator of transcription 5B
Polyclonal Antibody for Human Signal transducer and activator of transcription 5B
Polyclonal Antibody for Human Signal transducer and activator of transcription 5B
Monoclonal Antibody for Human Signal transducer and activator of transcription 5B
Monoclonal Antibody for Human Signal transducer and activator of transcription 5B
Monoclonal Antibody for Human Signal transducer and activator of transcription 5B
Monoclonal Antibody for Human Signal transducer and activator of transcription 5B
Monoclonal Antibody for Human Signal transducer and activator of transcription 5B
Protein for Human Signal transducer and activator of transcription 5B
Protein for Human Signal transducer and activator of transcription 5B
Protein for Human Signal transducer and activator of transcription 5B
Protein for Human Signal transducer and activator of transcription 5B
Protein for Human Signal transducer and activator of transcription 5B
R&D Technical Data
s
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s
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤6.3%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤10.6%
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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤3.9%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤7.7%
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Recovery
Recovery was determined by spiking various levels of STAT5B into serum and plasma .
Sample Type
Average(%)
Recovery Range(%)
Serum
100
95-106
Plasma
99
93-105
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Recovery was determined by spiking various levels of ACE into serum and plasma .
Sample Type
Average(%)
Recovery Range(%)
Serum
99
91-103
Plasma
98
93-106
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Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of STAT5B and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1:2
1:4
1:8
1:16
serum(n=5)
92-108%
95-106%
93-109%
91-107%
EDTA plasma(n=5)
90-106%
92-105%
95-102%
94-106%
heparin plasma(n=5)
93-105%
94-104%
91-108%
96-104%
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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1:2
1:4
1:8
1:16
serum(n=5)
92-105%
90-101%
95-105%
92-109%
EDTA plasma(n=5)
89-95%
93105%
89-94%
90-106%
heparin plasma(n=5)
93-104%
94-110%
101-111%
91-110%
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: PHOSPHORYLATION BY INSR;INTERACTION WITH INSR;MUTAGENESIS OF THR-684
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Cited for: PHOSPHORYLATION AT TYR-699;MUTAGENESIS OF TYR-699
9.
"A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus." Aoki N.
,
Matsuda T.
Mol. Endocrinol.16:58-69(2002)
[PubMed]
[Europe PMC]
[Abstract]
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Cited for: FUNCTION IN PROLACTIN SIGNALING PATHWAY;PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN2
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: VARIANT GHII SER-646;CHARACTERIZATION OF VARIANT GHII SER-646