SWAP70 ELISA Kit for Human(Homo sapiens) | EIAab.comSWAP70 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SWAP70(Gene name) > Human

SWAP70 (Gene name),

Switch-associated protein 70 (Protein name ), SWP70_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SWAP70(HSPC321;KIAA0640);

Protein name:

Switch-associated protein 70(SWAP-70);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70.

Function:

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.

Subcellular Location:

Cytoplasm Cell membrane Nucleus Cell projection lamellipodium In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.

Protein Attributes:

Sequence length:

585

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

585:

GSKNPHLITN | WGPAAFTEAE | LEEREKNWKE | KKTTE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000315630

UniGene:

Hs.153026

SMR:

Q9UH65

Pfam:

PF00169

KEGG:

hsa:23075

String:

Q9UH65

MIM:

604762

Uniprot:

Q9UH65

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ELISA Kit for Human SWAP-70

Cat.:

E3416h

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96T

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ELISA Kit for Human SWAP-70

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E3416c

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96T

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ELISA Kit for Human SWAP-70

Cat.:

E3416m

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96T

ELISA Kit for Human SWAP-70

Cat.:

E3416b

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96T

CLIA Kit for Human SWAP-70

Cat.:

U3416h

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96T

CLIA Kit for Human SWAP-70

Cat.:

U3416b

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96T

CLIA Kit for Human SWAP-70

MSDS:

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CLIA Kit for Human SWAP-70

Cat.:

U3416m

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96T

Polyclonal Antibody for Human SWAP-70

Cat.:

P3416Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human SWAP-70

Cat.:

P3416Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human SWAP-70

Monoclonal Antibody for Human SWAP-70

Protein for Human SWAP-70

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Association of SWAP-70 with the B cell antigen receptor complex."
Masat L. , Caldwell J. , Armstrong R. , Khoshnevisan H. , Jessberger R. , Herndier B. , Wabl M. , Ferrick D.
Proc. Natl. Acad. Sci. U.S.A.97:2180-2184(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION;MUTAGENESIS OF TRP-297
2.

"Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency."
Rapalus L. , Minegishi Y. , Lavoie A. , Cunningham-Rundles C. , Conley M.E.
Clin. Immunol.101:270-275(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-505
3.

"Human SWAP-70 homolog."
Monz D.W. , Comtesse N.E. , Heckel D.
Submitted (1999-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLU-505
4.

"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K. , Nagase T. , Suyama M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.5:169-176(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLU-505
tissue: Brain.
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLU-505
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Skin.
7.

"Human partial CDS from CD34+ stem cells."
Ye M. , Zhang Q.-H. , Zhou J. , Shen Y. , Wu X.-Y. , Guan Z.Q. , Wang L. , Fan H.-Y. , Mao Y.-F. , Dai M. , Huang Q.-H. , Chen S.-J. , Chen Z.
Submitted (1999-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 355-543
tissue: Umbilical cord blood.
8.

"SWAP-70 identifies a transitional subset of actin filaments in motile cells."
Hilpelae P. , Oberbanscheidt P. , Hahne P. , Hund M. , Kalhammer G. , Small J.V. , Baehler M.
Mol. Biol. Cell14:3242-3253(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF 223-ARG-ARG-224; ARG-230 AND 526-MET--GLU-585
9.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Solution structure of the PH domain of KIAA0640 protein from human."
RIKEN structural genomics initiative (RSGI)
Submitted (2006-10) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 211-312

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