Alpha-synuclein (Protein name
), SYUA_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Related Databases
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Gene name:
SNCA(NACP;PARK1);
Protein name:
Alpha-synuclein;
Alternative:
Non-A4 component of amyloid precursor(NACP);Non-A beta component of AD amyloid;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Soluble monomer which can form filamentous aggregates. Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones.
Function:
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Subcellular Location:
Cytoplasm
Membrane
Nucleus
Cell junction
synapse
Membrane-bound in dopaminergic neurons.
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12% SDS-PAGE Analysis
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Precision
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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤ 3.7%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤ 6.1%
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Recovery
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Recovery was determined by spiking various levels of ACE into serum and plasma .
Sample Type
Average(%)
Recovery Range(%)
Serum
94
91-98
Plasma
93
93-99
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Linearity
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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1:2
1:4
1:8
1:16
serum(n=5)
92-96%
90-99%
91-101%
92-104%
EDTA plasma(n=5)
89-95%
93-101%
89-94%
90-102%
heparin plasma(n=5)
93-102%
94-103%
96-102%
91-101%
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 61-95
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2-4 AND 2-5)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2-4)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L.
,
Schick M.
,
Neubert P.
,
Schatten R.
,
Henze S.
,
Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
9.
NIEHS SNPs program
Submitted (2005-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: PROTEIN SEQUENCE OF 59-96;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: PHOSPHORYLATION AT SER-87 AND SER-129 BY CK1 AND CK2
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Cited for: PHOSPHORYLATION BY G-PROTEIN COUPLED RECEPTOR KINASE
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Cited for: MUTAGENESIS OF TYR-39; TYR-125; TYR-133 AND TYR-136;CHARACTERIZATION OF VARIANT THR-53;PHOSPHORYLATION AT TYR-125
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Cited for: FIBRILS FORMATION;DOMAIN NAC;MUTAGENESIS OF 67-GLY--VAL-71; 71-VAL--VAL-82; 76-ALA-VAL-77; VAL-77; ALA-78 AND 85-ALA--PHE-94
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: STRUCTURE BY NMR IN COMPLEX WITH DETERGENT MICELLES
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Cited for: VARIANT PARK1 GLN-50;CHARACTERIZATION OF VARIANT PARK1 GLN-50