Gene name:
WARS (IFI53;WRS) ;
Protein name:
Tryptophanyl-tRNA synthetase, cytoplasmic ;
Alternative:
Tryptophan--tRNA ligase (TrpRS;hWRS) ;Interferon-induced protein 53 (IFP53) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Isoform 1 and isoform 2 interact with an oxidized form of GAPDH. GAPDH stimulates the aminoacylation activity of isoform 2.
Function:
Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MPNSEPASLL | ELFNSIATQG | ELVRSLKAGN | ASKDEIDSAV | KMLVSLKMSY |
100:
KAAAGEDYKA | DCPPGNPAPT | SNHGPDATEA | EEDFVDPWTV | QTSSAKGIDY |
150:
DKLIVRFGSS | KIDKELINRI | ERATGQRPHH | FLRRGIFFSH | RDMNQVLDAY |
200:
ENKKPFYLYT | GRGPSSEAMH | VGHLIPFIFT | KWLQDVFNVP | LVIQMTDDEK |
250:
YLWKDLTLDQ | AYSYAVENAK | DIIACGFDIN | KTFIFSDLDY | MGMSSGFYKN |
300:
VVKIQKHVTF | NQVKGIFGFT | DSDCIGKISF | PAIQAAPSFS | NSFPQIFRDR |
350:
TDIQCLIPCA | IDQDPYFRMT | RDVAPRIGYP | KPALLHSTFF | PALQGAQTKM |
400:
SASDPNSSIF | LTDTAKQIKT | KVNKHAFSGG | RDTIEEHRQF | GGNCDVDVSF |
450:
MYLTFFLEDD | DKLEQIRKDY | TSGAMLTGEL | KKALIEVLQP | LIAEHQARRK |
471:
EVTDEIVKEF | MTPRKLSFDF | Q
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Human
Rat
Rabbit
ELISA Kit for Human Tryptophanyl-tRNA synthetase, cytoplasmic
ELISA Kit for Human Tryptophanyl-tRNA synthetase, cytoplasmic
ELISA Kit for Human Tryptophanyl-tRNA synthetase, cytoplasmic
ELISA Kit for Human Tryptophanyl-tRNA synthetase, cytoplasmic
ELISA Kit for Human Tryptophanyl-tRNA synthetase, cytoplasmic
CLIA Kit for Human Tryptophanyl-tRNA synthetase, cytoplasmic
CLIA Kit for Human Tryptophanyl-tRNA synthetase, cytoplasmic
CLIA Kit for Human Tryptophanyl-tRNA synthetase, cytoplasmic
CLIA Kit for Human Tryptophanyl-tRNA synthetase, cytoplasmic
CLIA Kit for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Polyclonal Antibody for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Polyclonal Antibody for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Polyclonal Antibody for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Polyclonal Antibody for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Polyclonal Antibody for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Monoclonal Antibody for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Monoclonal Antibody for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Monoclonal Antibody for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Monoclonal Antibody for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Monoclonal Antibody for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Protein for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Protein for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Protein for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Protein for Human Tryptophanyl-tRNA synthetase, cytoplasmic
Protein for Human Tryptophanyl-tRNA synthetase, cytoplasmic
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Fetal liver .
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Nat. Genet.36:40-45(2004)
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Teratocarcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Blood .
tissue :
Lymph .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-13
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-141 AND 182-471
tissue :
Sperm .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-19; 142-162; 205-220; 278-298; 350-366 AND 433-448;INDUCTION
tissue :
Keratinocyte .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-24; 97-106; 433-448 AND 465-471;CLEAVAGE OF INITIATOR METHIONINE;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Colon carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 71-75 AND 91-98;PROTEOLYTIC CLEAVAGE;FUNCTION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 265-276; 278-296; 299-317 AND 350-365
tissue :
Keratinocyte .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
19.
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Cited for : FUNCTION
20.
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Cited for : INTERACTION WITH GAPDH
21.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
22.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
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PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
24.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
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Lasa M.
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Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-466
27.
"Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity."
Yu Y.
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J. Biol. Chem.279:8378-8388(2004)
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Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 94-471
28.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
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Jones S.
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Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] ASP-455