TAB3 ELISA Kit for Human(Homo sapiens) | EIAab.comTAB3 ELISA Kit for Human(Homo sapiens)

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TAB3 (Gene name),

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Protein name ), TAB3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TAB3(MAP3K7IP3);

Protein name:

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3;

Alternative:

NF-kappa-B-activating protein 1;Mitogen-activated protein kinase kinase kinase 7-interacting protein 3;TGF-beta-activated kinase 1-binding protein 3;TAK1-binding protein 3(TAB-3);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1.

Function:

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

712

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

712:

NRCEQCEMPR | YT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8N5C8

Pfam:

PF02845

KEGG:

hsa:257397

SMR:

Q8N5C8

UniGene:

Hs.188256

MIM:

300480

Uniprot:

Q8N5C8

FOR

ELISA Kit for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Cat.:

E2881h

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Manual:

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Packing:

96T

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ELISA Kit for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Cat.:

E2881m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Cat.:

U2881h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Cat.:

U2881m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Cat.:

P2881Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Cat.:

P2881Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Protein for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling."
Ishitani T. , Takaesu G. , Ninomiya-Tsuji J. , Shibuya H. , Gaynor R.B. , Matsumoto K.
EMBO J.22:6277-6288(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH MAP3K7; TRAF2 AND TRAF6;UBIQUITINATION;PHOSPHORYLATION;FUNCTION;VARIANT ARG-394
tissue: Kidney.
2.

"TAB3, a new binding partner of the protein kinase TAK1."
Cheung P.C. , Nebreda A.R. , Cohen P.
Biochem. J.378:27-34(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;PHOSPHORYLATION;INTERACTION WITH TAB1; TAB2 AND MAP3K7;VARIANT ARG-394
3.

"Identification of a human NF-kappaB-activating protein, TAB3."
Jin G. , Klika A. , Callahan M. , Faga B. , Danzig J. , Jiang Z. , Li X. , Stark G.R. , Harrington J. , Sherf B.
Proc. Natl. Acad. Sci. U.S.A.101:2028-2033(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);INTERACTION WITH MAP3K7 AND TRAF6;TISSUE SPECIFICITY;FUNCTION;VARIANT ARG-394
4.

"The DNA sequence of the human X chromosome."
Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-394
tissue: Eye.
6.

"RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."
Tian Y. , Zhang Y. , Zhong B. , Wang Y.Y. , Diao F.C. , Wang R.P. , Zhang M. , Chen D.Y. , Zhai Z.H. , Shu H.B.
J. Biol. Chem.282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBCK1
7.

"Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex."
Mendoza H. , Campbell D.G. , Burness K. , Hastie J. , Ronkina N. , Shim J.H. , Arthur J.S. , Davis R.J. , Gaestel M. , Johnson G.L. , Ghosh S. , Cohen P.
Biochem. J.409:711-722(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-506
8.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; THR-404 AND SER-492;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway."
Gao D. , Wang R. , Li B. , Yang Y. , Zhai Z. , Chen D.Y.
Cell. Mol. Life Sci.66:2573-2584(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WDR34
10.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"TRIM5 is an innate immune sensor for the retrovirus capsid lattice."
Pertel T. , Hausmann S. , Morger D. , Zueger S. , Guerra J. , Lascano J. , Reinhard C. , Santoni F.A. , Uchil P.D. , Chatel L. , Bisiaux A. , Albert M.L. , Strambio-De-Castillia C. , Mothes W. , Pizzato M. , Gruetter M.G. , Luban J.
Nature472:361-365(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM5

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