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Index > Protein center > TBC1D1(Gene name) > Human
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  • TBC1D1 (Gene name),
  • TBC1 domain family member 1 (Protein name ),  TBCD1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TBC1D1(KIAA1108);
    Protein name:
    TBC1 domain family member 1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1168
    Sequence:
    50:
    MEPITFTARK | HLLSNEVSVD | FGLQLVGSLP | VHSLTTMPML | PWVVAEVRRL | 
    100:
    SRQSTRKEPV | TKQVRLCVSP | SGLRCEPEPG | RSQQWDPLIY | SSIFECKPQR | 
    150:
    VHKLIHNSHD | PSYFACLIKE | DAVHRQSICY | VFKADDQTKV | PEIISSIRQA | 
    200:
    GKIARQEELH | CPSEFDDTFS | KKFEVLFCGR | VTVAHKKAPP | ALIDECIEKF | 
    250:
    NHVSGSRGSE | SPRPNPPHAA | PTGSQEPVRR | PMRKSFSQPG | LRSLAFRKEL | 
    300:
    QDGGLRSSGF | FSSFEESDIE | NHLISGHNIV | QPTDIEENRT | MLFTIGQSEV | 
    350:
    YLISPDTKKI | ALEKNFKEIS | FCSQGIRHVD | HFGFICRESS | GGGGFHFVCY | 
    400:
    VFQCTNEALV | DEIMMTLKQA | FTVAAVQQTA | KAPAQLCEGC | PLQSLHKLCE | 
    450:
    RIEGMNSSKT | KLELQKHLTT | LTNQEQATIF | EEVQKLRPRN | EQRENELIIS | 
    500:
    FLRCLYEEKQ | KEHIHIGEMK | QTSQMAAENI | GSELPPSATR | FRLDMLKNKA | 
    550:
    KRSLTESLES | ILSRGNKARG | LQEHSISVDL | DSSLSSTLSN | TSKEPSVCEK | 
    600:
    EALPISESSF | KLLGSSEDLS | SDSESHLPEE | PAPLSPQQAF | RRRANTLSHF | 
    650:
    PIECQEPPQP | ARGSPGVSQR | KLMRYHSVST | ETPHERKDFE | SKANHLGDSG | 
    700:
    GTPVKTRRHS | WRQQIFLRVA | TPQKACDSSS | RYEDYSELGE | LPPRSPLEPV | 
    750:
    CEDGPFGPPP | EEKKRTSREL | RELWQKAILQ | QILLLRMEKE | NQKLQASEND | 
    800:
    LLNKRLKLDY | EEITPCLKEV | TTVWEKMLST | PGRSKIKFDM | EKMHSAVGQG | 
    850:
    VPRHHRGEIW | KFLAEQFHLK | HQFPSKQQPK | DVPYKELLKQ | LTSQQHAILI | 
    900:
    DLGRTFPTHP | YFSAQLGAGQ | LSLYNILKAY | SLLDQEVGYC | QGLSFVAGIL | 
    950:
    LLHMSEEEAF | KMLKFLMFDM | GLRKQYRPDM | IILQIQMYQL | SRLLHDYHRD | 
    1000:
    LYNHLEEHEI | GPSLYAAPWF | LTMFASQFPL | GFVARVFDMI | FLQGTEVIFK | 
    1050:
    VALSLLGSHK | PLILQHENLE | TIVDFIKSTL | PNLGLVQMEK | TINQVFEMDI | 
    1100:
    AKQLQAYEVE | YHVLQEELID | SSPLSDNQRM | DKLEKTNSSL | RKQNLDLLEQ | 
    1150:
    LQVANGRIQS | LEATIEKLLS | SESKLKQAML | TLELERSALL | QTVEELRRRS | 
    1168:
    AEPSDREPEC | TQPEPTGD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    KEGG:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human TBC1 domain family member 1
    Cat.:
    E3428h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human TBC1 domain family member 1
    Cat.:
    E3428b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human TBC1 domain family member 1
    Cat.:
    E3428m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TBC1 domain family member 1
    Cat.:
    U3428h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TBC1 domain family member 1
    Cat.:
    U3428b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TBC1 domain family member 1
    Cat.:
    U3428m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human TBC1 domain family member 1
    Polyclonal Antibody for Human TBC1 domain family member 1
    Cat.:
    P3428Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TBC1 domain family member 1
    Cat.:
    P3428Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human TBC1 domain family member 1
    Monoclonal Antibody for Human TBC1 domain family member 1
    Monoclonal Antibody for Human TBC1 domain family member 1
    Protein for Human TBC1 domain family member 1
    Protein for Human TBC1 domain family member 1
    Protein for Human TBC1 domain family member 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 482-1168 (ISOFORM 1);VARIANT PRO-14
      tissue: Embryo.
      tissue: Hippocampus.
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    4. 4.
      "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R. , Nagase T. , Ishikawa K. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 406-1168 (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    6. 6.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    7. 7.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507; SER-565; SER-570; SER-573 AND SER-585;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    8. 8.
      "Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation."
      Park S.Y. , Jin W. , Woo J.R. , Shoelson S.E.
      J. Biol. Chem.286:18130-18138(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 750-1072;MUTAGENESIS OF MET-930 AND LEU-1019
    9. 9.
      "TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition."
      Stone S. , Abkevich V. , Russell D.L. , Riley R. , Timms K. , Tran T. , Trem D. , Frank D. , Jammulapati S. , Neff C.D. , Iliev D. , Gress R. , He G. , Frech G.C. , Adams T.D. , Skolnick M.H. , Lanchbury J.S. , Gutin A. , more...
      Hum. Mol. Genet.15:2709-2720(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-125
    10. 10.
      "R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population."
      Meyre D. , Farge M. , Lecoeur C. , Proenca C. , Durand E. , Allegaert F. , Tichet J. , Marre M. , Balkau B. , Weill J. , Delplanque J. , Froguel P.
      Hum. Mol. Genet.17:1798-1802(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-125
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