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Index > Protein center > TBP(Gene name) > Human
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  • TBP (Gene name),
  • TATA-box-binding protein (Protein name ),  TBP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TBP(GTF2D1;TF2D;TFIID);
    Protein name:
    TATA-box-binding protein;
    Alternative:
    TATA-binding factor;TATA sequence-binding protein;Transcription initiation factor TFIID TBP subunit;TATA-box factor;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds DNA as monomer. Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B TAF1C and TAF1D. Association of TBP to form either TFIID or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A, TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with UTF1. Interacts with BRF2. Interacts with UBTF. Interacts with GPBP1. Interacts with CITED2 (By similarity). Interacts with ATF7IP. Interacts with HIV-1 Tat.
    Function:
    General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    339
    Sequence:
    50:
    MDQNNSLPPY | AQGLASPQGA | MTPGIPIFSP | MMPYGTGLTP | QPIQNTNSLS | 
    100:
    ILEEQQRQQQ | QQQQQQQQQQ | QQQQQQQQQQ | QQQQQQQQQQ | QQQQQAVAAA | 
    150:
    AVQQSTSQQA | TQGTSGQAPQ | LFHSQTLTTA | PLPGTTPLYP | SPMTPMTPIT | 
    200:
    PATPASESSG | IVPQLQNIVS | TVNLGCKLDL | KTIALRARNA | EYNPKRFAAV | 
    250:
    IMRIREPRTT | ALIFSSGKMV | CTGAKSEEQS | RLAARKYARV | VQKLGFPAKF | 
    300:
    LDFKIQNMVG | SCDVKFPIRL | EGLVLTHQQF | SSYEPELFPG | LIYRMIKPRI | 
    339:
    VLLIFVSGKV | VLTGAKVRAE | IYEAFENIYP | ILKGFRKTT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    KEGG:
    Pfam:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human TATA-box-binding protein
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    E0360h
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    ELISA Kit for Human TATA-box-binding protein
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    E0360m
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    96T
    ELISA Kit for Human TATA-box-binding protein
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    E0360b
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    ELISA Kit for Human TATA-box-binding protein
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    E0360c
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    CLIA Kit for Human TATA-box-binding protein
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    U0360h
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    CLIA Kit for Human TATA-box-binding protein
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    U0360c
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    96T
    CLIA Kit for Human TATA-box-binding protein
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    U0360b
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    CLIA Kit for Human TATA-box-binding protein
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    U0360m
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    Polyclonal Antibody for Human TATA-box-binding protein
    Cat.:
    P0360Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TATA-box-binding protein
    Polyclonal Antibody for Human TATA-box-binding protein
    Polyclonal Antibody for Human TATA-box-binding protein
    Cat.:
    P0360Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human TATA-box-binding protein
    Monoclonal Antibody for Human TATA-box-binding protein
    Monoclonal Antibody for Human TATA-box-binding protein
    Monoclonal Antibody for Human TATA-box-binding protein
    Protein for Human TATA-box-binding protein
    Protein for Human TATA-box-binding protein
    Protein for Human TATA-box-binding protein
    Protein for Human TATA-box-binding protein

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Highly conserved core domain and unique N-terminus with presumptive regulatory motifs in a human TATA factor (TFIID)."
      Hoffmann A. , Sinn E. , Yamamoto T. , Wang J. , Roy A. , Horikoshi M. , Roeder R.G.
      Nature346:387-390(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT 92-GLN--GLN-95 DEL
    2. 2.
      "Functional domains and upstream activation properties of cloned human TATA binding protein."
      Peterson M.G. , Tanese N. , Pugh B.F. , Tjian R.
      Science248:1625-1630(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);DOMAINS
    3. 3.
      "Cloning of a transcriptionally active human TATA binding factor."
      Kao C.C. , Lieberman P.M. , Schmidt M.C. , Zhou Q. , Pei R. , Berk A.J.
      Science248:1646-1650(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fibroblast.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Uterus.
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein."
      Kwon H. , Green M.R.
      J. Biol. Chem.269:30140-30146(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBFT
    8. 8.
      "Direct interaction of human TFIID with the HIV-1 transactivator tat."
      Kashanchi F. , Piras G. , Radonovich M.F. , Duvall J.F. , Fattaey A. , Chiang C.M. , Roeder R.G. , Brady J.N.
      Nature367:295-299(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT
    9. 9.
      "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits."
      Comai L. , Zomerdijk J.C.B.M. , Beckmann H. , Zhou S. , Admon A. , Tjian R.
      Science266:1966-1972(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAF1A; TAF1B AND TAF1C
    10. 10.
      "Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo."
      Veschambre P. , Simard P. , Jalinot P.
      J. Mol. Biol.250:169-180(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT
    11. 11.
      "Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity."
      Fukushima A. , Okuda A. , Nishimoto M. , Seki N. , Hori T.A. , Muramatsu M.
      J. Biol. Chem.273:25840-25849(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UTF1
    12. 12.
      "Requirement of RSF and FACT for transcription of chromatin templates in vitro."
      LeRoy G. , Orphanides G. , Lane W.S. , Reinberg D.
      Science282:1900-1904(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE TFIID COMPLEX
    13. 13.
      "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter."
      Friedrich J.K. , Panov K.I. , Cabart P. , Russell J. , Zomerdijk J.C.B.M.
      J. Biol. Chem.280:29551-29558(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE SL1/TIF-IB COMPLEX
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    15. 15.
      "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1."
      Rao S. , Matsumura A. , Yoon J. , Simon M.C.
      J. Biol. Chem.274:11115-11124(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPIB
    16. 16.
      "A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."
      Lee S.-K. , Anzick S.L. , Choi J.-E. , Bubendorf L. , Guan X.-Y. , Jung Y.-K. , Kallioniemi O.-P. , Kononen J. , Trent J.M. , Azorsa D. , Jhun B.-H. , Cheong J.H. , Lee Y.C. , Meltzer P.S. , Lee J.W.
      J. Biol. Chem.274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
    17. 17.
      "Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP)."
      Chang C.-H. , Scott G.K. , Baldwin M.A. , Benz C.C.
      Oncogene18:3682-3695(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ELF3
    18. 18.
      "BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein."
      Cabart P. , Murphy S.
      J. Biol. Chem.276:43056-43064(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BRF2
    19. 19.
      "The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger."
      Gangloff Y.G. , Pointud J.-C. , Thuault S. , Carre L. , Romier C. , Muratoglu S. , Brand M. , Tora L. , Couderc J.-L. , Davidson I.
      Mol. Cell. Biol.21:5109-5121(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAF3
    20. 20.
      "Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis."
      Wang P.J. , Page D.C.
      Hum. Mol. Genet.11:2341-2346(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAF1L
    21. 21.
      "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
      Hinkley C.S. , Hirsch H.A. , Gu L. , LaMere B. , Henry R.W.
      J. Biol. Chem.278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNAPC1; SNAPC2 AND SNAPC4
    22. 22.
      "HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs."
      Raha T. , Cheng S.W.G. , Green M.R.
      PLoS Biol.3:221-230(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT
    23. 23.
      "MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity."
      Liu L. , Ishihara K. , Ichimura T. , Fujita N. , Hino S. , Tomita S. , Watanabe S. , Saitoh N. , Ito T. , Nakao M.
      J. Biol. Chem.284:5165-5174(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SP1
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    25. 25.
      "Crystal structure of a human TATA box-binding protein/TATA element complex."
      Nikolov D.B. , Chen H. , Halay E.D. , Hoffmann A. , Roeder R.G. , Burley S.K.
      Proc. Natl. Acad. Sci. U.S.A.93:4862-4867(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 159-337 IN COMPLEX WITH DNA
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 159-339 IN COMPLEX WITH DNA
    27. 27.
      "Structural basis of preinitiation complex assembly on human pol II promoters."
      Tsai F.T.F. , Sigler P.B.
      EMBO J.19:25-36(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 159-337 IN COMPLEX WITH GTF2B AND DNA
    28. 28.
      "Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex."
      Kamada K. , Shu F. , Chen H. , Malik S. , Stelzer G. , Roeder R.G. , Meisterernst M. , Burley S.K.
      Cell106:71-81(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.62 ANGSTROMS) OF 159-339 IN COMPLEX WITH DR1; DRAP1 AND DNA
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      "A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?"
      Koide R. , Kobayashi S. , Shimohata T. , Ikeuchi T. , Maruyama M. , Saito M. , Yamada M. , Takahashi H. , Tsuji S.
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      "Different types of repeat expansion in the TATA-binding protein gene are associated with a new form of inherited ataxia."
      Zuhlke C. , Hellenbroich Y. , Dalski A. , Kononowa N. , Hagenah J. , Vieregge P. , Riess O. , Klein C. , Schwinger E.
      Eur. J. Hum. Genet.9:160-164(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM OF POLY-GLN REGION;INVOLVEMENT IN SCA17
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      "SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein."
      Nakamura K. , Jeong S.-Y. , Uchihara T. , Anno M. , Nagashima K. , Nagashima T. , Ikeda S. , Tsuji S. , Kanazawa I.
      Hum. Mol. Genet.10:1441-1448(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM OF POLY-GLN REGION;INVOLVEMENT IN SCA17
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM OF POLY-GLN REGION;INVOLVEMENT IN SCA17
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