Gene name:
TBP (GTF2D1;TF2D;TFIID) ;
Protein name:
TATA-box-binding protein ;
Alternative:
TATA-binding factor ;TATA sequence-binding protein ;Transcription initiation factor TFIID TBP subunit ;TATA-box factor ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds DNA as monomer. Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B TAF1C and TAF1D. Association of TBP to form either TFIID or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A, TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with UTF1. Interacts with BRF2. Interacts with UBTF. Interacts with GPBP1. Interacts with CITED2 (By similarity). Interacts with ATF7IP. Interacts with HIV-1 Tat.
Function:
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MDQNNSLPPY | AQGLASPQGA | MTPGIPIFSP | MMPYGTGLTP | QPIQNTNSLS |
100:
ILEEQQRQQQ | QQQQQQQQQQ | QQQQQQQQQQ | QQQQQQQQQQ | QQQQQAVAAA |
150:
AVQQSTSQQA | TQGTSGQAPQ | LFHSQTLTTA | PLPGTTPLYP | SPMTPMTPIT |
200:
PATPASESSG | IVPQLQNIVS | TVNLGCKLDL | KTIALRARNA | EYNPKRFAAV |
250:
IMRIREPRTT | ALIFSSGKMV | CTGAKSEEQS | RLAARKYARV | VQKLGFPAKF |
300:
LDFKIQNMVG | SCDVKFPIRL | EGLVLTHQQF | SSYEPELFPG | LIYRMIKPRI |
339:
VLLIFVSGKV | VLTGAKVRAE | IYEAFENIYP | ILKGFRKTT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Chicken
ELISA Kit for Human TATA-box-binding protein
ELISA Kit for Human TATA-box-binding protein
ELISA Kit for Human TATA-box-binding protein
ELISA Kit for Human TATA-box-binding protein
CLIA Kit for Human TATA-box-binding protein
CLIA Kit for Human TATA-box-binding protein
CLIA Kit for Human TATA-box-binding protein
CLIA Kit for Human TATA-box-binding protein
Polyclonal Antibody for Human TATA-box-binding protein
Polyclonal Antibody for Human TATA-box-binding protein
Polyclonal Antibody for Human TATA-box-binding protein
Polyclonal Antibody for Human TATA-box-binding protein
Monoclonal Antibody for Human TATA-box-binding protein
Monoclonal Antibody for Human TATA-box-binding protein
Monoclonal Antibody for Human TATA-box-binding protein
Monoclonal Antibody for Human TATA-box-binding protein
Protein for Human TATA-box-binding protein
Protein for Human TATA-box-binding protein
Protein for Human TATA-box-binding protein
Protein for Human TATA-box-binding protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UBFT
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HIV-1 TAT
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TAF1A; TAF1B AND TAF1C
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HIV-1 TAT
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UTF1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE TFIID COMPLEX
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION OF THE SL1/TIF-IB COMPLEX
14.
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DNA Cell Biol.26:369-385(2007)
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SPIB
16.
"A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."
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J. Biol. Chem.274:34283-34293(1999)
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PubMed ]
[
Europe PMC ]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NCOA6
17.
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Cited for : INTERACTION WITH ELF3
18.
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Cited for : INTERACTION WITH BRF2
19.
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Cited for : INTERACTION WITH TAF3
20.
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Cited for : INTERACTION WITH TAF1L
21.
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Cited for : INTERACTION WITH SNAPC1; SNAPC2 AND SNAPC4
22.
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Cited for : INTERACTION WITH HIV-1 TAT
23.
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Cited for : INTERACTION WITH SP1
24.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 159-337 IN COMPLEX WITH DNA
26.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 159-339 IN COMPLEX WITH DNA
27.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 159-337 IN COMPLEX WITH GTF2B AND DNA
28.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.62 ANGSTROMS) OF 159-339 IN COMPLEX WITH DR1; DRAP1 AND DNA
29.
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Cited for : POLYMORPHISM OF POLY-GLN REGION
30.
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Cited for : POLYMORPHISM OF POLY-GLN REGION;INVOLVEMENT IN SCA17
31.
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Cited for : POLYMORPHISM OF POLY-GLN REGION;INVOLVEMENT IN SCA17
32.
"Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n allele at the SCA17 locus."
Silveira I.
,
Miranda C.
,
Guimaraes L.
,
Moreira M.-C.
,
Alonso I.
,
Mendonca P.
,
Ferro A.
,
Pinto-Basto J.
,
Coelho J.
,
Ferreirinha F.
,
Poirier J.
,
Parreira E.
,
Vale J.
,
Januario C.
,
Barbot C.
,
Tuna A.
,
Barros J.
,
Koide R.
,
Tsuji S.
,
Holmes S.E.
,
Margolis R.L.
,
Jardim L.
,
Pandolfo M.
,
Coutinho P.
,
Sequeiros J.
more...
Arch. Neurol.59:623-629(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : POLYMORPHISM OF POLY-GLN REGION;INVOLVEMENT IN SCA17