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Index > Protein center > TCN2(Gene name) > Human
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  • TCN2 (Gene name),
  • Transcobalamin-2 (Protein name ),  TCO2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TCN2(TC2);
    Protein name:
    Transcobalamin-2(TC-2);
    Alternative:
    Transcobalamin II(TC II;TCII);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    427
    Sequence:
    50:
    MRHLGAFLFL | LGVLGALTEM | CEIPEMDSHL | VEKLGQHLLP | WMDRLSLEHL | 
    100:
    NPSIYVGLRL | SSLQAGTKED | LYLHSLKLGY | QQCLLGSAFS | EDDGDCQGKP | 
    150:
    SMGQLALYLL | ALRANCEFVR | GHKGDRLVSQ | LKWFLEDEKR | AIGHDHKGHP | 
    200:
    HTSYYQYGLG | ILALCLHQKR | VHDSVVDKLL | YAVEPFHQGH | HSVDTAAMAG | 
    250:
    LAFTCLKRSN | FNPGRRQRIT | MAIRTVREEI | LKAQTPEGHF | GNVYSTPLAL | 
    300:
    QFLMTSPMRG | AELGTACLKA | RVALLASLQD | GAFQNALMIS | QLLPVLNHKT | 
    350:
    YIDLIFPDCL | APRVMLEPAA | ETIPQTQEII | SVTLQVLSLL | PPYRQSISVL | 
    400:
    AGSTVEDVLK | KAHELGGFTY | ETQASLSGPY | LTSVMGKAAG | EREFWQLLRD | 
    427:
    PNTPLLQGIA | DYRPKDGETI | ELRLVSW
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    SMR:
    Pfam:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human TC-2
    Cat.:
    E12876r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human TC-2
    Cat.:
    E12876h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human TC-2
    MSDS:
    Please sign in first.
    ELISA Kit for Human TC-2
    Cat.:
    E12876m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human TC-2
    MSDS:
    Please sign in first.
    CLIA Kit for Human TC-2
    Cat.:
    U12876r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TC-2
    Cat.:
    U12876m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TC-2
    Cat.:
    U12876h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human TC-2
    Cat.:
    P12876Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TC-2
    Polyclonal Antibody for Human TC-2
    Polyclonal Antibody for Human TC-2
    Monoclonal Antibody for Human TC-2
    Monoclonal Antibody for Human TC-2
    Monoclonal Antibody for Human TC-2
    Monoclonal Antibody for Human TC-2
    Protein for Human TC-2
    Protein for Human TC-2
    Protein for Human TC-2
    Protein for Human TC-2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The cDNA sequence and the deduced amino acid sequence of human transcobalamin II show homology with rat intrinsic factor and human transcobalamin I."
      Platica O. , Janeczko R. , Quadros E.V. , Regec A. , Romain R. , Rothenberg S.P.
      J. Biol. Chem.266:7860-7863(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS THR-198; LEU-219; PRO-259 AND SER-376
    2. 2.
      "Isolation and sequence analysis of variant forms of human transcobalamin II."
      Li N. , Seetharam S. , Lindemans J. , Alpers D.H. , Arwert F. , Seetharam B.
      Biochim. Biophys. Acta1172:21-30(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "The cloning and characterization of the human transcobalamin II gene."
      Regec A. , Quadros E.V. , Platica O. , Rothenberg S.P.
      Blood85:2711-2719(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-259
    5. 5.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT GLN-227
      tissue: Brain.
      tissue: Eye.
    7. 7.
      "Purification and molecular characterization of human transcobalamin II."
      Quadros E.V. , Rothenberg S.P. , Pan Y.C.E. , Stein S.
      J. Biol. Chem.261:15455-15460(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-37
    8. 8.
      "Functional human transcobalamin II isoproteins are secreted by insect cells using the baculovirus expression system."
      Quadros E.V. , Sai P. , Rothenberg S.P.
      Blood81:1239-1245(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-26
    9. 9.
      "Structural basis for mammalian vitamin B12 transport by transcobalamin."
      Wuerges J. , Garau G. , Geremia S. , Fedosov S.N. , Petersen T.E. , Randaccio L.
      Proc. Natl. Acad. Sci. U.S.A.103:4386-4391(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 19-427 IN COMPLEX WITH COBALAMIN;DISULFIDE BONDS
    10. 10.
      "Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood."
      Namour F. , Olivier J. , Abdelmouttaleb I. , Adjalla C. , Debard R. , Salvat C. , Gueant J.
      Blood97:1092-1098(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-259
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