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Index > Protein center > DNTT(Gene name) > Human
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  • DNTT (Gene name),
  • DNA nucleotidylexotransferase (Protein name ),  TDT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DNTT(TDT);
    Protein name:
    DNA nucleotidylexotransferase;
    Alternative:
    Terminal deoxynucleotidyltransferase(Terminal transferase);Terminal addition enzyme;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA.
    Function:
    Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    509
    Sequence:
    50:
    MDPPRASHLS | PRKKRPRQTG | ALMASSPQDI | KFQDLVVFIL | EKKMGTTRRA | 
    100:
    FLMELARRKG | FRVENELSDS | VTHIVAENNS | GSDVLEWLQA | QKVQVSSQPE | 
    150:
    LLDVSWLIEC | IRAGKPVEMT | GKHQLVVRRD | YSDSTNPGPP | KTPPIAVQKI | 
    200:
    SQYACQRRTT | LNNCNQIFTD | AFDILAENCE | FRENEDSCVT | FMRAASVLKS | 
    250:
    LPFTIISMKD | TEGIPCLGSK | VKGIIEEIIE | DGESSEVKAV | LNDERYQSFK | 
    300:
    LFTSVFGVGL | KTSEKWFRMG | FRTLSKVRSD | KSLKFTRMQK | AGFLYYEDLV | 
    350:
    SCVTRAEAEA | VSVLVKEAVW | AFLPDAFVTM | TGGFRRGKKM | GHDVDFLITS | 
    400:
    PGSTEDEEQL | LQKVMNLWEK | KGLLLYYDLV | ESTFEKLRLP | SRKVDALDHF | 
    450:
    QKCFLIFKLP | RQRVDSDQSS | WQEGKTWKAI | RVDLVLCPYE | RRAFALLGWT | 
    500:
    GSRQFERDLR | RYATHERKMI | LDNHALYDKT | KRIFLKAESE | EEIFAHLGLD | 
    509:
    YIEPWERNA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    UniGene:
    SMR:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human DNA nucleotidylexotransferase
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    E1548h
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    ELISA Kit for Human DNA nucleotidylexotransferase
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    E1548c
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    ELISA Kit for Human DNA nucleotidylexotransferase
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    E1548m
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    ELISA Kit for Human DNA nucleotidylexotransferase
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    E1548b
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    96T
    CLIA Kit for Human DNA nucleotidylexotransferase
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    U1548m
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    96T
    CLIA Kit for Human DNA nucleotidylexotransferase
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    U1548h
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    96T
    CLIA Kit for Human DNA nucleotidylexotransferase
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    U1548b
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    96T
    CLIA Kit for Human DNA nucleotidylexotransferase
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    U1548c
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    Packing:
    96T
    Polyclonal Antibody for Human DNA nucleotidylexotransferase
    Cat.:
    P1548Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DNA nucleotidylexotransferase
    Polyclonal Antibody for Human DNA nucleotidylexotransferase
    Polyclonal Antibody for Human DNA nucleotidylexotransferase
    Cat.:
    P1548Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human DNA nucleotidylexotransferase
    Monoclonal Antibody for Human DNA nucleotidylexotransferase
    Monoclonal Antibody for Human DNA nucleotidylexotransferase
    Monoclonal Antibody for Human DNA nucleotidylexotransferase
    Protein for Human DNA nucleotidylexotransferase
    Protein for Human DNA nucleotidylexotransferase
    Protein for Human DNA nucleotidylexotransferase
    Protein for Human DNA nucleotidylexotransferase

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Expression of human terminal deoxynucleotidyl transferase in Escherichia coli."
      Peterson R.C. , Cheung L.C. , Mattaliano R.J. , White S.T. , Chang L.M.S. , Bollum F.J.
      J. Biol. Chem.260:10495-10502(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT GLY-112
    2. 2.
      "Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region."
      Riley L.K. , Morrow J.K. , Danton M.J. , Coleman M.S.
      Proc. Natl. Acad. Sci. U.S.A.85:2489-2493(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-112
    3. 3.
      "Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen."
      Ibe S. , Fujita K. , Toyomoto T. , Shimazaki N. , Kaneko R. , Tanabe A. , Takebe I. , Kuroda S. , Kobayashi T. , Toji S. , Tamai K. , Yamamoto H. , Koiwai O.
      Genes Cells6:815-824(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-112
    4. 4.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-112
      tissue: Thymus.
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-112
      tissue: Testis.
    7. 7.
      "Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene."
      Koiwai O. , Morita A.
      Biochem. Biophys. Res. Commun.154:91-100(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-508 (ISOFORM 2)
    9. 9.
      "Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65."
      Yamashita N. , Shimazaki N. , Ibe S. , Kaneko R. , Tanabe A. , Toyomoto T. , Fujita K. , Hasegawa T. , Toji S. , Tamai K. , Yamamoto H. , Koiwai O.
      Genes Cells6:641-652(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNTTIP1
      tissue: Thymus.
    10. 10.
      "Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone."
      Fujita K. , Shimazaki N. , Ohta Y. , Kubota T. , Ibe S. , Toji S. , Tamai K. , Fujisaki S. , Hayano T. , Koiwai O.
      Genes Cells8:559-571(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNTTIP2 AND CORE HISTONE
    11. 11.
      "Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase."
      Mahajan K.N. , Mitchell B.S.
      Proc. Natl. Acad. Sci. U.S.A.100:10746-10751(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRP19
    12. 12.
      "Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase."
      Yang B. , Gathy K.N. , Coleman M.S.
      J. Biol. Chem.269:11859-11868(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
    13. 13.
      "Solution structure of BRCT domain of terminal deoxynucleotidyltransferase."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 19-125
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