DNTT ELISA Kit for Human(Homo sapiens) | EIAab.comDNTT ELISA Kit for Human(Homo sapiens)

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Index > Protein center > DNTT(Gene name) > Human

DNTT (Gene name),

DNA nucleotidylexotransferase (Protein name ), TDT_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

DNTT(TDT);

Protein name:

DNA nucleotidylexotransferase;

Alternative:

Terminal deoxynucleotidyltransferase(Terminal transferase);Terminal addition enzyme;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA.

Function:

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

509

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

509:

YIEPWERNA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

187410

STRING:

9606.ENSP00000360216

UniGene:

Hs.534206

SMR:

P04053

Pfam:

PF00533

String:

P04053

KEGG:

hsa:1791

Uniprot:

P04053

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ELISA Kit for Human DNA nucleotidylexotransferase

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E1548h

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Manual:

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96T

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ELISA Kit for Human DNA nucleotidylexotransferase

Cat.:

E1548c

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96T

ELISA Kit for Human DNA nucleotidylexotransferase

Cat.:

E1548m

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96T

ELISA Kit for Human DNA nucleotidylexotransferase

Cat.:

E1548b

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96T

CLIA Kit for Human DNA nucleotidylexotransferase

Cat.:

U1548m

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Packing:

96T

CLIA Kit for Human DNA nucleotidylexotransferase

Cat.:

U1548h

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Packing:

96T

CLIA Kit for Human DNA nucleotidylexotransferase

Cat.:

U1548b

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Packing:

96T

CLIA Kit for Human DNA nucleotidylexotransferase

Cat.:

U1548c

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Packing:

96T

Polyclonal Antibody for Human DNA nucleotidylexotransferase

Cat.:

P1548Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human DNA nucleotidylexotransferase

Cat.:

P1548Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human DNA nucleotidylexotransferase

Protein for Human DNA nucleotidylexotransferase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression of human terminal deoxynucleotidyl transferase in Escherichia coli."
Peterson R.C. , Cheung L.C. , Mattaliano R.J. , White S.T. , Chang L.M.S. , Bollum F.J.
J. Biol. Chem.260:10495-10502(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT GLY-112
2.

"Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region."
Riley L.K. , Morrow J.K. , Danton M.J. , Coleman M.S.
Proc. Natl. Acad. Sci. U.S.A.85:2489-2493(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-112
3.

"Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen."
Ibe S. , Fujita K. , Toyomoto T. , Shimazaki N. , Kaneko R. , Tanabe A. , Takebe I. , Kuroda S. , Kobayashi T. , Toji S. , Tamai K. , Yamamoto H. , Koiwai O.
Genes Cells6:815-824(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-112
4.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-112
tissue: Thymus.
5.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-112
tissue: Testis.
7.

"Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene."
Koiwai O. , Morita A.
Biochem. Biophys. Res. Commun.154:91-100(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67
8.

"Molecular cloning of human terminal deoxynucleotidyltransferase."
Peterson R.C. , Cheung L.C. , Mattaliano R.J. , Chang L.M.S. , Bollum F.J.
Proc. Natl. Acad. Sci. U.S.A.81:4363-4367(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-508 (ISOFORM 2)
9.

"Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65."
Yamashita N. , Shimazaki N. , Ibe S. , Kaneko R. , Tanabe A. , Toyomoto T. , Fujita K. , Hasegawa T. , Toji S. , Tamai K. , Yamamoto H. , Koiwai O.
Genes Cells6:641-652(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNTTIP1
tissue: Thymus.
10.

"Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone."
Fujita K. , Shimazaki N. , Ohta Y. , Kubota T. , Ibe S. , Toji S. , Tamai K. , Fujisaki S. , Hayano T. , Koiwai O.
Genes Cells8:559-571(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNTTIP2 AND CORE HISTONE
11.

"Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase."
Mahajan K.N. , Mitchell B.S.
Proc. Natl. Acad. Sci. U.S.A.100:10746-10751(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRP19
12.

"Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase."
Yang B. , Gathy K.N. , Coleman M.S.
J. Biol. Chem.269:11859-11868(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
13.

"Solution structure of BRCT domain of terminal deoxynucleotidyltransferase."
RIKEN structural genomics initiative (RSGI)
Submitted (2005-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 19-125

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