Protein name:
Tenascin (TN) ;
Alternative:
GMEM ;Cytotactin ;Glioma-associated-extracellular matrix antigen ;GP 150-225 ;JI ;Hexabrachion ;Neuronectin ;Myotendinous antigen ;Tenascin-C (TN-C) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
Function:
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MGAMTQLLAG | VFLAFLALAT | EGGVLKKVIR | HKRQSGVNAT | LPEENQPVVF |
100:
NHVYNIKLPV | GSQCSVDLES | ASGEKDLAPP | SEPSESFQEH | TVDGENQIVF |
150:
THRINIPRRA | CGCAAAPDVK | ELLSRLEELE | NLVSSLREQC | TAGAGCCLQP |
200:
ATGRLDTRPF | CSGRGNFSTE | GCGCVCEPGW | KGPNCSEPEC | PGNCHLRGRC |
250:
IDGQCICDDG | FTGEDCSQLA | CPSDCNDQGK | CVNGVCICFE | GYAGADCSRE |
300:
ICPVPCSEEH | GTCVDGLCVC | HDGFAGDDCN | KPLCLNNCYN | RGRCVENECV |
350:
CDEGFTGEDC | SELICPNDCF | DRGRCINGTC | YCEEGFTGED | CGKPTCPHAC |
400:
HTQGRCEEGQ | CVCDEGFAGV | DCSEKRCPAD | CHNRGRCVDG | RCECDDGFTG |
450:
ADCGELKCPN | GCSGHGRCVN | GQCVCDEGYT | GEDCSQLRCP | NDCHSRGRCV |
500:
EGKCVCEQGF | KGYDCSDMSC | PNDCHQHGRC | VNGMCVCDDG | YTGEDCRDRQ |
550:
CPRDCSNRGL | CVDGQCVCED | GFTGPDCAEL | SCPNDCHGQG | RCVNGQCVCH |
600:
EGFMGKDCKE | QRCPSDCHGQ | GRCVDGQCIC | HEGFTGLDCG | QHSCPSDCNN |
650:
LGQCVSGRCI | CNEGYSGEDC | SEVSPPKDLV | VTEVTEETVN | LAWDNEMRVT |
700:
EYLVVYTPTH | EGGLEMQFRV | PGDQTSTIIQ | ELEPGVEYFI | RVFAILENKK |
750:
SIPVSARVAT | YLPAPEGLKF | KSIKETSVEV | EWDPLDIAFE | TWEIIFRNMN |
800:
KEDEGEITKS | LRRPETSYRQ | TGLAPGQEYE | ISLHIVKNNT | RGPGLKRVTT |
850:
TRLDAPSQIE | VKDVTDTTAL | ITWFKPLAEI | DGIELTYGIK | DVPGDRTTID |
900:
LTEDENQYSI | GNLKPDTEYE | VSLISRRGDM | SSNPAKETFT | TGLDAPRNLR |
950:
RVSQTDNSIT | LEWRNGKAAI | DSYRIKYAPI | SGGDHAEVDV | PKSQQATTKT |
1000:
TLTGLRPGTE | YGIGVSAVKE | DKESNPATIN | AATELDTPKD | LQVSETAETS |
1050:
LTLLWKTPLA | KFDRYRLNYS | LPTGQWVGVQ | LPRNTTSYVL | RGLEPGQEYN |
1100:
VLLTAEKGRH | KSKPARVKAS | TEQAPELENL | TVTEVGWDGL | RLNWTAADQA |
1150:
YEHFIIQVQE | ANKVEAARNL | TVPGSLRAVD | IPGLKAATPY | TVSIYGVIQG |
1200:
YRTPVLSAEA | STGETPNLGE | VVVAEVGWDA | LKLNWTAPEG | AYEYFFIQVQ |
1250:
EADTVEAAQN | LTVPGGLRST | DLPGLKAATH | YTITIRGVTQ | DFSTTPLSVE |
1300:
VLTEEVPDMG | NLTVTEVSWD | ALRLNWTTPD | GTYDQFTIQV | QEADQVEEAH |
1350:
NLTVPGSLRS | MEIPGLRAGT | PYTVTLHGEV | RGHSTRPLAV | EVVTEDLPQL |
1400:
GDLAVSEVGW | DGLRLNWTAA | DNAYEHFVIQ | VQEVNKVEAA | QNLTLPGSLR |
1450:
AVDIPGLEAA | TPYRVSIYGV | IRGYRTPVLS | AEASTAKEPE | IGNLNVSDIT |
1500:
PESFNLSWMA | TDGIFETFTI | EIIDSNRLLE | TVEYNISGAE | RTAHISGLPP |
1550:
STDFIVYLSG | LAPSIRTKTI | SATATTEALP | LLENLTISDI | NPYGFTVSWM |
1600:
ASENAFDSFL | VTVVDSGKLL | DPQEFTLSGT | QRKLELRGLI | TGIGYEVMVS |
1650:
GFTQGHQTKP | LRAEIVTEAE | PEVDNLLVSD | ATPDGFRLSW | TADEGVFDNF |
1700:
VLKIRDTKKQ | SEPLEITLLA | PERTRDITGL | REATEYEIEL | YGISKGRRSQ |
1750:
TVSAIATTAM | GSPKEVIFSD | ITENSATVSW | RAPTAQVESF | RITYVPITGG |
1800:
TPSMVTVDGT | KTQTRLVKLI | PGVEYLVSII | AMKGFEESEP | VSGSFTTALD |
1850:
GPSGLVTANI | TDSEALARWQ | PAIATVDSYV | ISYTGEKVPE | ITRTVSGNTV |
1900:
EYALTDLEPA | TEYTLRIFAE | KGPQKSSTIT | AKFTTDLDSP | RDLTATEVQS |
1950:
ETALLTWRPP | RASVTGYLLV | YESVDGTVKE | VIVGPDTTSY | SLADLSPSTH |
2000:
YTAKIQALNG | PLRSNMIQTI | FTTIGLLYPF | PKDCSQAMLN | GDTTSGLYTI |
2050:
YLNGDKAEAL | EVFCDMTSDG | GGWIVFLRRK | NGRENFYQNW | KAYAAGFGDR |
2100:
REEFWLGLDN | LNKITAQGQY | ELRVDLRDHG | ETAFAVYDKF | SVGDAKTRYK |
2150:
LKVEGYSGTA | GDSMAYHNGR | SFSTFDKDTD | SAITNCALSY | KGAFWYRNCH |
2200:
RVNLMGRYGD | NNHSQGVNWF | HWKGHEHSIQ | FAEMKLRPSN | FRNLEGRRKR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Pig
Chicken
Polyclonal Antibody for Human TN
Polyclonal Antibody for Human TN
Polyclonal Antibody for Human TN
Polyclonal Antibody for Human TN
Monoclonal Antibody for Human TN
Monoclonal Antibody for Human TN
Monoclonal Antibody for Human TN
Monoclonal Antibody for Human TN
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
R Liu, Y He, B Li, et al.
References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-539; LEU-1677 AND GLN-2008
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4 AND 5);PROTEIN SEQUENCE OF 23-32;VARIANTS ARG-680 AND GLN-2008
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-539; LEU-1677 AND GLN-2008
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 46-125 (ISOFORMS 1/2/3/4/5/6)
tissue :
Fetal cartilage .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 431-2055 (ISOFORMS 1 AND 6);VARIANTS ARG-539; LEU-1677 AND GLN-2008
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Glioblastoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CSPG4
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1809
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Plasma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS DFNA56 MET-1773 AND SER-1796