Protein name:
Tenascin-R (TN-R) ;
Alternative:
Restrictin ;Janusin ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms oligomers. Interacts with CNTN1, TNC, and FN1. Interacts with BCAN and AGC1 in a calcium-dependent manner. Interacts with SCN2B, PTPRZ1, and CSPG3.
Function:
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MGADGETVVL | KNMLIGINLI | LLGSMIKPSE | CQLEVTTERV | QRQSVEEEGG |
100:
IANYNTSSKE | QPVVFNHVYN | INVPLDNLCS | SGLEASAEQE | VSAEDETLAE |
150:
YMGQTSDHES | QVTFTHRINF | PKKACPCASS | AQVLQELLSR | IEMLEREVSV |
200:
LRDQCNANCC | QESAATGQLD | YIPHCSGHGN | FSFESCGCIC | NEGWFGKNCS |
250:
EPYCPLGCSS | RGVCVDGQCI | CDSEYSGDDC | SELRCPTDCS | SRGLCVDGEC |
300:
VCEEPYTGED | CRELRCPGDC | SGKGRCANGT | CLCEEGYVGE | DCGQRQCLNA |
350:
CSGRGQCEEG | LCVCEEGYQG | PDCSAVAPPE | DLRVAGISDR | SIELEWDGPM |
400:
AVTEYVISYQ | PTALGGLQLQ | QRVPGDWSGV | TITELEPGLT | YNISVYAVIS |
450:
NILSLPITAK | VATHLSTPQG | LQFKTITETT | VEVQWEPFSF | SFDGWEISFI |
500:
PKNNEGGVIA | QVPSDVTSFN | QTGLKPGEEY | IVNVVALKEQ | ARSPPTSASV |
550:
STVIDGPTQI | LVRDVSDTVA | FVEWIPPRAK | VDFILLKYGL | VGGEGGRTTF |
600:
RLQPPLSQYS | VQALRPGSRY | EVSVSAVRGT | NESDSATTQF | TTEIDAPKNL |
650:
RVGSRTATSL | DLEWDNSEAE | VQEYKVVYST | LAGEQYHEVL | VPRGIGPTTR |
700:
ATLTDLVPGT | EYGVGISAVM | NSQQSVPATM | NARTELDSPR | DLMVTASSET |
750:
SISLIWTKAS | GPIDHYRITF | TPSSGIASEV | TVPKDRTSYT | LTDLEPGAEY |
800:
IISVTAERGR | QQSLESTVDA | FTGFRPISHL | HFSHVTSSSV | NITWSDPSPP |
850:
ADRLILNYSP | RDEEEEMMEV | SLDATKRHAV | LMGLQPATEY | IVNLVAVHGT |
900:
VTSEPIVGSI | TTGIDPPKDI | TISNVTKDSV | MVSWSPPVAS | FDYYRVSYRP |
950:
TQVGRLDSSV | VPNTVTEFTI | TRLNPATEYE | ISLNSVRGRE | ESERICTLVH |
1000:
TAMDNPVDLI | ATNITPTEAL | LQWKAPVGEV | ENYVIVLTHF | AVAGETILVD |
1050:
GVSEEFRLVD | LLPSTHYTAT | MYATNGPLTS | GTISTNFSTL | LDPPANLTAS |
1100:
EVTRQSALIS | WQPPRAEIEN | YVLTYKSTDG | SRKELIVDAE | DTWIRLEGLL |
1150:
ENTDYTVLLQ | AAQDTTWSSI | TSTAFTTGGR | VFPHPQDCAQ | HLMNGDTLSG |
1200:
VYPIFLNGEL | SQKLQVYCDM | TTDGGGWIVF | QRRQNGQTDF | FRKWADYRVG |
1250:
FGNVEDEFWL | GLDNIHRITS | QGRYELRVDM | RDGQEAAFAS | YDRFSVEDSR |
1300:
NLYKLRIGSY | NGTAGDSLSY | HQGRPFSTED | RDNDVAVTNC | AMSYKGAWWY |
1350:
KNCHRTNLNG | KYGESRHSQG | INWYHWKGHE | FSIPFVEMKM | RPYNHRLMAG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
Polyclonal Antibody for Human TN-R
Polyclonal Antibody for Human TN-R
Polyclonal Antibody for Human TN-R
Polyclonal Antibody for Human TN-R
Monoclonal Antibody for Human TN-R
Monoclonal Antibody for Human TN-R
Monoclonal Antibody for Human TN-R
Monoclonal Antibody for Human TN-R
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;VARIANT VAL-17
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT VAL-17
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT THR-36 AND THR-37;STRUCTURE OF CARBOHYDRATES
tissue :
Cerebrospinal fluid .