Protein name:
Telomerase protein component 1 (rTLP1) ;
Alternative:
p230 ;Telomerase-associated protein 1 (Telomerase protein 1) ;p80 telomerase homolog ;p240 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.
Function:
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.
Subcellular Location:
Nucleus
Chromosome
telomere
Protein Attributes:
50:
MEKLCGYVPV | HPDILSLKNR | CLTMLSDIQP | LEKIHGQRSV | NPDILSLENR |
100:
CLTLLPDLQP | MEKIHGQRSV | HPDILSSENR | CLTLLPDLQS | LEKLCGHMSS |
150:
HPDVLSLENR | CLATLPTVKR | TVSSGPLLQC | LHRSHTAQAD | LRDPNFRNCL |
200:
FPEPPTIEAP | CFLKELDLPT | GPRALKSMSA | TARVQEVALG | QRCVSEGKEL |
250:
QEEKESAEVP | MPLYSLSLGG | EEEEVVGAPV | LKLTSGDSDS | HPETTDQILQ |
300:
EKKMALLTLL | CSAMASSVNV | KDASDPTRAS | IHEVCSALAP | LEPEFILKAS |
350:
LYARQQLNLR | DIANIVLAVA | ALLPACRPHV | RRYYSAIVHL | PSDWIQVAEF |
400:
YQSLAEGDEK | KLVPLPACLR | AAMTDKFAQF | DEYQLAKYNP | RKHRSKTRSR |
450:
QPPRPQRTKP | PFSESGKCFP | KSVWPLKNEQ | ISFEAAYNAV | SEKKRLPRFT |
500:
LKKLVEQLHI | HEPAQHVQAL | LGYRYPSTLE | LFSRSHLPGP | WDSSRAGQRM |
550:
KLQRPETWER | ELSLRGNRAS | VWEELIDNGK | LPFMAMLRNL | CNLLRTGISA |
600:
HHHELVLQRL | QHEKSVIHSR | QFPFRFLNAH | DSLDRLEAQL | RSKASPFPSN |
650:
TTLMKRIMIR | NSKKIKRPAN | PRYLCTLTQR | QLRAAMAIPV | MYEHLKREKL |
700:
RLHKARQWTC | DLELLERYRQ | ALETAVNISV | KHNLPPLPGR | TLLVYLTDAN |
750:
ANRLCPKSHL | QGPPLNYVLL | LIGMMMARAE | QTTVWLCGTG | TVKTPVLTAD |
800:
EGILKTAIKL | QAQVQELEEN | DEWPLETFEK | YLLSLAVRRT | PIDRVILFGQ |
850:
RMDTELLNVA | KQIIWQHVNS | KCLFVSVLLR | KMQYMSPNLN | PNDVTLSGCT |
900:
DGILKFIAEH | GASRLLEHVG | QLDKIFKIPP | PPGKTKVSPL | RPLEENNPGP |
950:
FVPISQHGWR | NIRLFISSTF | RDMHGERDLL | MRSVLPALQA | RAFPHRISLH |
1000:
AIDLRWGITE | EETRRNRQLE | VCLGEVENSQ | LFVGILGSRY | GYTPPSYDLP |
1050:
DHPHFHWTQR | YPSGRSVTEM | EVMQFLNRGQ | RSEPSDQALI | YFRDPGFLSS |
1100:
VPDVWKPDFI | SESEEAAHRV | SELKRFLQEQ | KEVTCRRYSC | EWGGVAAGRP |
1150:
YTGGLEEFGQ | LVLQDVWSVI | QKRYLQPGAQ | LEQPGSISEE | DLIQASFQQL |
1200:
KSPPSPARPR | LLQDTVQQLM | LPHGRLSLVI | GQAGQGKTAF | LASLVSALKV |
1250:
PDQPNVAPFV | FFHFSAARPD | QCLAFNLLRR | LCTHLHQKLG | EPSALPSTYR |
1300:
GLVWELQQKL | LLKSAQWLQP | GQTLVLIIDG | ADKLVDHNGQ | LISDWIPKSL |
1350:
PRRVHLVLSV | SSDSGLGETL | QQSQSAYVVA | LGSLVPSSRA | QLVREELALY |
1400:
GKRLEESPFN | NQMRLLLAKQ | GSSLPLYLHL | VTDYLRLFTL | YEQVSERLRT |
1450:
LPATLPLLLQ | HILSTLEQEH | GHNVLPQALT | ALEVTHSGLT | VDQLHAVLST |
1500:
WLTLPKETKS | WEEAVAASHS | GNLYPLAPFA | YLVQSLRSLL | GEGPVERPGA |
1550:
RLCLSDGPLR | TAVKRRYGKR | LGLEKTAHVL | IAAHLWKMCD | PDASGTFRSC |
1600:
PPEALKDLPY | HLLQSGNHGL | LAKFLTNLHV | VAAYLEVGLV | PDLLEAYELY |
1650:
ASSKPEVNQK | LPEADVAVFH | NFLKQQASLL | TQYPLLLLQQ | AASQPEESPV |
1700:
CCQAPLLTQR | WHNQCILKWI | NKPQTLKGQQ | SLSLPISSSP | TAVAFSPNGQ |
1750:
RAAVGTAGGT | IYLLNLRTWQ | EEKALVSGCD | GISSFAFLSD | TALFLTTFDG |
1800:
LLELWDLQHG | CWVFQTKAHQ | YQITGCCLSP | DRRLLATVCL | GGYVKLWDTV |
1850:
QGQLAFQYTH | PKSLNCITFH | PEGQVVATGN | WSGIVTFFQA | DGLKVTKELG |
1900:
GPGPSVRTLA | FSAPGKVVAL | GRIDGTVELW | AWQEGTRLAA | FPAQCGGVST |
1950:
VLFLHAGGRF | LTAGEDGKAQ | LWSGFLGRPR | GCLGSLYLSP | ALSVALNPDG |
2000:
DQVAVGYRGD | GIKIYRISSG | PQEAQCQELN | VAVSALVWLS | PSVLVSGAED |
2050:
GSLHGWMLRR | NSLQSLWLSS | VCQKPVLGLA | ASQEFLASAS | EDFTVRLWPR |
2100:
QLLTQPHAVE | ELPCAAELRG | HEGPVCCCSF | SPDGRILATA | GRDRNLLCWD |
2150:
VKVAQAPLLI | HTFSSCHRDW | ITGCTWTKDN | ILISCSSDGS | VGLWNPEAGQ |
2200:
QLGQFPGHQS | AVSAVVAVEE | HIVSVSRDGT | LKVWDRQGVE | LTSIPAHSGP |
2250:
ISQCAAALEP | RPAGQPGSEL | MVVTVGLDGA | TKLWHPLLVC | QIHTLQGHSG |
2300:
PVTAAAASEA | SGLLLTSDNS | SVRLWQIPKE | ADDTCKPRSS | AVITAVAWAP |
2350:
DGSLVVSGNE | AGELTLWQKA | QAVATARAPG | RVSDLIWCSA | NAFFVLSANE |
2400:
NVSEWQVELR | KGSTCTNFRL | YLKRVLQEDL | GVLTGMALAP | DGQSLILMKE |
2450:
DVELLQMKPG | STPSSICRRY | AVHSSILCTS | KDYGLFYLQQ | GNSGSLSILE |
2500:
QEESGKFEKT | LDFNLNLNNP | NGSPVSITQA | EPESGSSLLC | ATSDGMLWNL |
2550:
SECTPEGEWV | VDNIWQKKSR | NPKSRTPGTD | SSPGLFCMDS | WVEPTHLKAR |
2600:
QCKKIHLGSV | TALHVLPGLL | VTASEDRDVK | LWERPSMQLL | GLFRCEGPVS |
2629:
CLEPWMEPSS | PLQLAVGDAQ | GNLYFLSWE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Polyclonal Antibody for Rat rTLP1
Polyclonal Antibody for Rat rTLP1
Polyclonal Antibody for Rat rTLP1
Monoclonal Antibody for Rat rTLP1
Monoclonal Antibody for Rat rTLP1
Monoclonal Antibody for Rat rTLP1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX
strain :
Fischer 344 .
tissue :
Fibroblast .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ELECTRON CRYOMICROSCOPY (22 ANGSTROMS) OF VAULT COMPLEX AND TEP1 WD REPEATS MODELING