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Index > Protein center > RELA(Gene name) > Human
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  • RELA (Gene name),
  • Transcription factor p65 (Protein name ),  TF65_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RELA(NFKB3);
    Protein name:
    Transcription factor p65;
    Alternative:
    Nuclear factor NF-kappa-B p65 subunit;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-c-Rel complex. Homodimer; component of the NF-kappa-B p65-p65 complex. Component of the NF-kappa-B p65-p52 complex. May interact with ETHE1. Binds AES and TLE1. Interacts with TP53BP2. Binds to and is phosphorylated by the activated form of either RPS6KA4 or RPS6KA5. Interacts with ING4 and this interaction may be indirect. Interacts with CARM1, USP48 and UNC5CL. Interacts with IRAK1BP1 (By similarity).Interacts with NFKBID (By similarity). Interacts with NFKBIA. Interacts with GSK3B. Interacts with NFKBIB (By similarity). Interacts with NFKBIE. Interacts with NFKBIZ. Interacts with EHMT1 (via ANK repeats) (By similarity). Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HDAC3; HDAC3 mediates the deacetylation of RELA. Interacts with HDAC1; the interaction requires non-phosphorylated RELA. Interacts with CBP; the interaction requires phosphorylated RELA. Interacts (phosphorylated at 'Thr-254') with PIN1; the interaction inhibits p65 binding to NFKBIA. Interacts with SOCS1. Interacts with UXT. Interacts with MTDH and PHF11. Interacts with ARRB2. Interacts with human respiratory syncytial virus (HRSV) protein M2-1. Interacts with NFKBIA (when phosphorylated), the interaction is direct; phosphorylated NFKBIA is part of a SCF(BTRC)-like complex lacking CUL1. Interacts with RNF25. Interacts (via C-terminus) with DDX1. Interacts with UFL1 and COMMD1. Interacts with BRMS1; this promotes deacetylation of 'Lys-310'. Interacts with NOTCH2 (By similarity). Directly interacts with MEN1; this interaction represses NFKB-mediated transactivation. Interacts with AKIP1, which promotes the phosphorylation and nuclear retention of RELA.
    Function:
    NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1.
    Subcellular Location:
    Nucleus Cytoplasm Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalized with RELA in the nucleus upon TNF-alpha induction.
    Protein Attributes:
    Sequence length:
    551
    Sequence:
    50:
    MDELFPLIFP | AEPAQASGPY | VEIIEQPKQR | GMRFRYKCEG | RSAGSIPGER | 
    100:
    STDTTKTHPT | IKINGYTGPG | TVRISLVTKD | PPHRPHPHEL | VGKDCRDGFY | 
    150:
    EAELCPDRCI | HSFQNLGIQC | VKKRDLEQAI | SQRIQTNNNP | FQVPIEEQRG | 
    200:
    DYDLNAVRLC | FQVTVRDPSG | RPLRLPPVLS | HPIFDNRAPN | TAELKICRVN | 
    250:
    RNSGSCLGGD | EIFLLCDKVQ | KEDIEVYFTG | PGWEARGSFS | QADVHRQVAI | 
    300:
    VFRTPPYADP | SLQAPVRVSM | QLRRPSDREL | SEPMEFQYLP | DTDDRHRIEE | 
    350:
    KRKRTYETFK | SIMKKSPFSG | PTDPRPPPRR | IAVPSRSSAS | VPKPAPQPYP | 
    400:
    FTSSLSTINY | DEFPTMVFPS | GQISQASALA | PAPPQVLPQA | PAPAPAPAMV | 
    450:
    SALAQAPAPV | PVLAPGPPQA | VAPPAPKPTQ | AGEGTLSEAL | LQLQFDDEDL | 
    500:
    GALLGNSTDP | AVFTDLASVD | NSEFQQLLNQ | GIPVAPHTTE | PMLMEYPEAI | 
    550:
    TRLVTGAQRP | PDPAPAPLGA | PGLPNGLLSG | DEDFSSIADM | DFSALLSQIS | 
    551:
    S
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    String:
    UniGene:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Transcription factor p65
    Cat.:
    E0616h
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    ELISA Kit for Human Transcription factor p65
    Cat.:
    E0616m
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    Packing:
    96T
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    ELISA Kit for Human Transcription factor p65
    Cat.:
    E0616c
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    Packing:
    96T
    CLIA Kit for Human Transcription factor p65
    Cat.:
    U0616h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Transcription factor p65
    Cat.:
    U0616m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Transcription factor p65
    Cat.:
    U0616c
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Transcription factor p65
    Cat.:
    P0616Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Transcription factor p65
    Polyclonal Antibody for Human Transcription factor p65
    Cat.:
    P0616Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Transcription factor p65
    Monoclonal Antibody for Human Transcription factor p65
    Monoclonal Antibody for Human Transcription factor p65
    Protein for Human Transcription factor p65
    Protein for Human Transcription factor p65
    Protein for Human Transcription factor p65

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    Linearity
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    References
    1. 1.
      "Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B."
      Ruben S.M. , Dillon P.J. , Schreck R. , Henkel T. , Chen C.-H. , Maher M. , Baeuerle P.A. , Rosen C.A.
      Science251:1490-1493(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing."
      Deloukas P. , van Loon A.P.G.M.
      Hum. Mol. Genet.2:1895-1900(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING
    3. 3.
      "An alternatively spliced transcript, p65 delta 2, of the gene encoding the p65 subunit of the transcription factor NF-kappa B."
      Lyle R. , Valleley E.M. , Sharpe P.T. , Hewitt J.E.
      Gene138:265-266(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Bone.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Colon.
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-551
    6. 6.
      "Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative."
      Ruben S.M. , Narayanan R. , Klement J.F. , Chen C.-H. , Rosen C.A.
      Mol. Cell. Biol.12:444-454(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 214-239 (ISOFORMS 1/2 AND 3);ACTIVATION DOMAIN
    7. 7.
      "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene."
      Hansen S.K. , Nerlov C. , Zabel U. , Verde P. , Johnsen M. , Baeuerle P.A. , Blasi F.
      EMBO J.11:205-213(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NF-KAPPA-B P65-P50 COMPLEX;IDENTIFICATION IN THE NF-KAPPA-B P65-C-REL COMPLEX
    8. 8.
      "I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding."
      Ganchi P.A. , Sun S.C. , Greene W.C. , Ballard D.W.
      Mol. Biol. Cell3:1339-1352(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFKBIA
    9. 9.
      "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor."
      Beg A.A. , Baldwin A.S. Jr.
      Oncogene9:1487-1492(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NF-KAPPA-B P65-C-REL COMPLEX;IDENTIFICATION IN THE NF-KAPPA-B P65-P52 COMPLEX
    10. 10.
      "Regulation of intercellular adhesion molecule-1 gene by tumor necrosis factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50."
      Aoudjit F. , Brochu N. , Belanger B. , Stratowa C. , Hiscott J. , Audette M.
      Cell Growth Differ.8:335-342(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NF-KAPPA-B P65-P65 COMPLEX;IDENTIFICATION IN THE NF-KAPPA-B P65-C-REL COMPLEX
    11. 11.
      "A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription."
      Li Z. , Nabel G.J.
      Mol. Cell. Biol.17:6184-6190(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFKBIE
    12. 12.
      "IKAP is a scaffold protein of the IkappaB kinase complex."
      Cohen L. , Henzel W.J. , Baeuerle P.A.
      Nature395:292-296(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH CHUK; IKBKB; NFKBIA; IKBKAP AND MAP3K14
    13. 13.
      "IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain."
      Sakurai H. , Chiba H. , Miyoshi H. , Sugita T. , Toriumi W.
      J. Biol. Chem.274:30353-30356(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-536
    14. 14.
      "NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2."
      Yang J.-P. , Hori M. , Takahashi N. , Kawabe T. , Kato H. , Okamoto T.
      Oncogene18:5177-5186(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH TP53BP2
    15. 15.
      "Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers."
      Schulte R. , Grassl G.A. , Preger S. , Fessele S. , Jacobi C.A. , Schaller M. , Nelson P.J. , Autenrieth I.B.
      FASEB J.14:1471-1484(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE NF-KAPPA-B P65-P65 COMPLEX
    16. 16.
      "Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats."
      Tetsuka T. , Uranishi H. , Imai H. , Ono T. , Sonta S. , Takahashi N. , Asamitsu K. , Okamoto T.
      J. Biol. Chem.275:4383-4390(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AES AND TLE1
    17. 17.
      "Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II."
      Wang D. , Westerheide S.D. , Hanson J.L. , Baldwin A.S. Jr.
      J. Biol. Chem.275:32592-32597(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-529
    18. 18.
      "The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation."
      Heppner C. , Bilimoria K.Y. , Agarwal S.K. , Kester M. , Whitty L.J. , Guru S.C. , Chandrasekharappa S.C. , Collins F.S. , Spiegel A.M. , Marx S.J. , Burns A.L.
      Oncogene20:4917-4925(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MEN1
    19. 19.
      "Duration of nuclear NF-kappaB action regulated by reversible acetylation."
      Chen L.F. , Fischle W. , Verdin E. , Greene W.C.
      Science293:1653-1657(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;INTERACTION WITH HDAC3
    20. 20.
      "A novel protein overexpressed in hepatoma accelerates export of NF-kappa B from the nucleus and inhibits p53-dependent apoptosis."
      Higashitsuji H. , Higashitsuji H. , Nagao T. , Nonoguchi K. , Fujii S. , Itoh K. , Fujita J.
      Cancer Cell2:335-346(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ETHE1
    21. 21.
      "Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB."
      Chen L.F. , Mu Y. , Greene W.C.
      EMBO J.21:6539-6548(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-218; LYS-221 AND LYS-310
    22. 22.
      "The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1."
      Zhong H. , May M.J. , Jimi E. , Ghosh S.
      Mol. Cell9:625-636(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBP AND HDAC1;PHOSPHORYLATION
    23. 23.
      "Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)."
      Vermeulen L. , De Wilde G. , Van Damme P. , Vanden Berghe W. , Haegeman G.
      EMBO J.22:1313-1324(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RPS6KA5;MUTAGENESIS OF SER-276;PHOSPHORYLATION AT SER-276
    24. 24.
      "Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65."
      Kiernan R. , Bres V. , Ng R.W. , Coudart M.-P. , El Messaoudi S. , Sardet C. , Jin D.-Y. , Emiliani S. , Benkirane M.
      J. Biol. Chem.278:2758-2766(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-122 AND LYS-123
    25. 25.
      "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit."
      Asamitsu K. , Tetsuka T. , Kanazawa S. , Okamoto T.
      J. Biol. Chem.278:26879-26887(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH RNF25
    26. 26.
      "Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability."
      Demarchi F. , Bertoli C. , Sandy P. , Schneider C.
      J. Biol. Chem.278:39583-39590(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GSK3B
    27. 27.
      "Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA."
      Ryo A. , Suizu F. , Yoshida Y. , Perrem K. , Liou Y.C. , Wulf G. , Rottapel R. , Yamaoka S. , Lu K.P.
      Mol. Cell12:1413-1426(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-254;INTERACTION WITH PIN1 AND SOCS1;MUTAGENESIS OF THR-254
    28. 28.
      "Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB."
      Zhang J. , Xu L.-G. , Han K.-J. , Shu H.-B.
      J. Biol. Chem.279:17819-17825(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UNC5CL
    29. 29.
      "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation."
      Yeh P.Y. , Yeh K.H. , Chuang S.E. , Song Y.C. , Cheng A.L.
      J. Biol. Chem.279:26143-26148(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-435
    30. 30.
      "Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response."
      Saccani S. , Marazzi I. , Beg A.A. , Natoli G.
      J. Exp. Med.200:107-113(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    31. 31.
      "Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways."
      Gao H. , Sun Y. , Wu Y. , Luan B. , Wang Y. , Qu B. , Pei G.
      Mol. Cell14:303-317(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2
    32. 32.
      "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis."
      Garkavtsev I. , Kozin S.V. , Chernova O. , Xu L. , Winkler F. , Brown E. , Barnett G.H. , Jain R.K.
      Nature428:328-332(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ING4
    33. 33.
      "Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor."
      Rocha S. , Garrett M.D. , Campbell K.J. , Schumm K. , Perkins N.D.
      EMBO J.24:1157-1169(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-505
    34. 34.
      "IKKbeta phosphorylates p65 at S468 in transactivation domain 2."
      Schwabe R.F. , Sakurai H.
      FASEB J.19:1758-1760(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-468
    35. 35.
      "cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B."
      Anrather J. , Racchumi G. , Iadecola C.
      J. Biol. Chem.280:244-252(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-281
    36. 36.
      "COMMD proteins, a novel family of structural and functional homologs of MURR1."
      Burstein E. , Hoberg J.E. , Wilkinson A.S. , Rumble J.M. , Csomos R.A. , Komarck C.M. , Maine G.N. , Wilkinson J.C. , Mayo M.W. , Duckett C.S.
      J. Biol. Chem.280:22222-22232(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COMMD1;SUBCELLULAR LOCATION
    37. 37.
      "NF-kappaB RelA phosphorylation regulates RelA acetylation."
      Chen L.F. , Williams S.A. , Mu Y. , Nakano H. , Duerr J.M. , Buckbinder L. , Greene W.C.
      Mol. Cell. Biol.25:7966-7975(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-310
    38. 38.
      "Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B."
      Reimers K. , Buchholz K. , Werchau H.
      Virology331:260-268(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HRSV PROTEIN M2-1
    39. 39.
      "Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis."
      Emdad L. , Sarkar D. , Su Z.-Z. , Randolph A. , Boukerche H. , Valerie K. , Fisher P.B.
      Cancer Res.66:1509-1516(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MTDH
    40. 40.
      "Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB."
      Tzimas C. , Michailidou G. , Arsenakis M. , Kieff E. , Mosialos G. , Hatzivassiliou E.G.
      Cell. Signal.18:83-92(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP48
    41. 41.
      "Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon."
      Mattioli I. , Geng H. , Sebald A. , Hodel M. , Bucher C. , Kracht M. , Schmitz M.L.
      J. Biol. Chem.281:6175-6183(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-468
    42. 42.
      "Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis."
      Liu Y. , Smith P.W. , Jones D.R.
      Mol. Cell. Biol.26:8683-8696(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BRMS1;FUNCTION;ACETYLATION AT LYS-310
    43. 43.
      "Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17."
      Miao F. , Li S. , Chavez V. , Lanting L. , Natarajan R.
      Mol. Endocrinol.20:1562-1573(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CARM1
    44. 44.
      "IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation."
      Song Y.J. , Jen K.Y. , Soni V. , Kieff E. , Cahir-McFarland E.
      Proc. Natl. Acad. Sci. U.S.A.103:2689-2694(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NF-KAPPA-B P65-P52 COMPLEX
    45. 45.
      "Nine-amino-acid transactivation domain: establishment and prediction utilities."
      Piskacek S. , Gregor M. , Nemethova M. , Grabner M. , Kovarik P. , Piskacek M.
      Genomics89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN
    46. 46.
      "UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome."
      Sun S. , Tang Y. , Lou X. , Zhu L. , Yang K. , Zhang B. , Shi H. , Wang C.
      J. Cell Biol.178:231-244(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UXT
    47. 47.
      "The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment."
      Chae J.J. , Wood G. , Richard K. , Jaffe H. , Colburn N.T. , Masters S.L. , Gumucio D.L. , Shoham N.G. , Kastner D.L.
      Blood112:1794-1803(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MEFV
    48. 48.
      "Functional characterization of the atopy-associated gene PHF11."
      Clarke E. , Rahman N. , Page N. , Rolph M.S. , Stewart G.J. , Jones G.J.
      J. Allergy Clin. Immunol.121:1148-1154(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PHF11
    49. 49.
      "AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65."
      Gao N. , Asamitsu K. , Hibi Y. , Ueno T. , Okamoto T.
      J. Biol. Chem.283:7834-7843(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKIP1
    50. 50.
      "The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription."
      Ishaq M. , Ma L. , Wu X. , Mu Y. , Pan J. , Hu J. , Hu T. , Fu Q. , Guo D.
      J. Cell. Biochem.106:296-305(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DDX1;SUBCELLULAR LOCATION
    51. 51.
      "Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA."
      Huang B. , Yang X.D. , Zhou M.M. , Ozato K. , Chen L.F.
      Mol. Cell. Biol.29:1375-1387(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BRD4;ACETYLATION AT LYS-310
    52. 52.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-310;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    53. 53.
      "A novel LZAP-binding protein, NLBP, inhibits cell invasion."
      Kwon J. , Cho H.J. , Han S.H. , No J.G. , Kwon J.Y. , Kim H.
      J. Biol. Chem.285:12232-12240(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UFL1
    54. 54.
      "SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310."
      Rothgiesser K.M. , Erener S. , Waibel S. , Luscher B. , Hottiger M.O.
      J. Cell Sci.123:4251-4258(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEACETYLATION BY SIRT2
    55. 55.
      "Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65."
      Sharif-Askari E. , Vassen L. , Kosan C. , Khandanpour C. , Gaudreau M.C. , Heyd F. , Okayama T. , Jin J. , Rojas M.E. , Grimes H.L. , Zeng H. , Moroy T.
      Mol. Cell. Biol.30:3929-3942(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GFI1;SUBCELLULAR LOCATION;INDUCTION;FUNCTION
    56. 56.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    57. 57.
      "NF-kappaB repression by PIAS3 mediated RelA SUMOylation."
      Liu Y. , Bridges R. , Wortham A. , Kulesz-Martin M.
      PLoS ONE7:E37636-E37636(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-37; LYS-122 AND LYS-123 BY PIAS3
    58. 58.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    59. 59.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH C11ORF95
    60. 60.
      "Structure of an IkappaBalpha/NF-kappaB complex."
      Jacobs M.D. , Harrison S.C.
      Cell95:749-758(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS)
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