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Index > Protein center > TFF1(Gene name) > Human
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  • TFF1 (Gene name),
  • Trefoil factor 1 (Protein name ),  TFF1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TFF1(BCEI;PS2);
    Protein name:
    Trefoil factor 1;
    Alternative:
    PNR-2;Breast cancer estrogen-inducible protein;Protein pS2;Polypeptide P1.A(hP1.A);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer with GKN2; disulfide linked.
    Function:
    Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    84
    Sequence:
    50:
    MATMENKVIC | ALVLVSMLAL | GTLAEAQTET | CTVAPRERQN | CGFPGVTPSQ | 
    84:
    CANKGCCFDD | TVRGVPWCFY | PNTIDVPPEE | ECEF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    MIM:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Trefoil factor 1
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    E1049h
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    96T
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    ELISA Kit for Human Trefoil factor 1
    Cat.:
    E1049d
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    Packing:
    96T
    ELISA Kit for Human Trefoil factor 1
    Cat.:
    E1049r
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    96T
    ELISA Kit for Human Trefoil factor 1
    Cat.:
    E1049m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Trefoil factor 1
    Cat.:
    U1049m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Trefoil factor 1
    Cat.:
    U1049h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Trefoil factor 1
    Cat.:
    U1049r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Trefoil factor 1
    Cat.:
    U1049d
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Trefoil factor 1
    Cat.:
    P1049Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Trefoil factor 1
    Cat.:
    P1049Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Trefoil factor 1
    Polyclonal Antibody for Human Trefoil factor 1
    Cat.:
    P1049Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Trefoil factor 1
    Monoclonal Antibody for Human Trefoil factor 1
    Monoclonal Antibody for Human Trefoil factor 1
    Monoclonal Antibody for Human Trefoil factor 1
    Protein for Human Trefoil factor 1
    Protein for Human Trefoil factor 1
    Protein for Human Trefoil factor 1
    Protein for Human Trefoil factor 1

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    Precision
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    Linearity
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    References
    1. 1.
      "Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7."
      Jakowlew S.B. , Breathnach R. , Jeltsch J.-M. , Masiakowski P. , Chambon P.
      Nucleic Acids Res.12:2861-2878(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Cloning of a gene expressed in human breast cancer and regulated by estrogen in MCF-7 cells."
      Prud'Homme J.-F. , Fridlansky F. , le Cunff M. , Atger M. , Mercier-Bodart C. , Pichon M.-F. , Milgrom E.
      DNA4:11-21(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Mammary cancer.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma."
      Takahashi H. , Kida N. , Fujii R. , Tanaka K. , Ohta M. , Mori K. , Hayashi K.
      FEBS Lett.261:283-286(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Gastric carcinoma.
    5. 5.
      "Complete primary structure of the human estrogen-responsive gene (pS2) product."
      Mori K. , Fujii R. , Kida N. , Takahashi H. , Ohkubo S. , Fujino M. , Ohta M. , Hayashi K.
      J. Biochem.107:73-76(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region."
      Berry A. , Scott H.S. , Kudoh J. , Talior I. , Korostishevsky M. , Wattenhofer M. , Guipponi M. , Barras C. , Rossier C. , Shibuya K. , Wang J. , Kawasaki K. , Asakawa S. , Minoshima S. , Shimizu N. , Antonarakis S.E. , Bonne-Tamir B.
      Genomics68:22-29(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
      tissue: Kidney.
      tissue: Stomach.
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-84
    9. 10.
      "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP-C."
      Westley B.R. , Griffin S.M. , May F.E.B.
      Biochemistry44:7967-7975(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-84;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH GKN2
      tissue: Stomach.
    10. 11.
      "Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor."
      Chutipongtanate S. , Nakagawa Y. , Sritippayawan S. , Pittayamateekul J. , Parichatikanond P. , Westley B.R. , May F.E. , Malasit P. , Thongboonkerd V.
      J. Clin. Invest.115:3613-3622(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-63;FUNCTION;TISSUE SPECIFICITY
    11. 12.
      "Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product."
      Mori K. , Fujii R. , Kida N. , Ohta M. , Hayashi K.
      Biochem. Biophys. Res. Commun.155:366-372(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-60
    12. 13.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-39
    13. 14.
      "Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa."
      Rio M.C. , Bellocq J.-P. , Daniel J.Y. , Tomasetto C. , Lathe R. , Chenard M.P. , Batzenschlager A. , Chambon P.
      Science241:705-708(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    14. 15.
      "Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer."
      Shi S.-Q. , Cai J.-T. , Yang J.-M.
      World J. Gastroenterol.12:3119-3122(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    15. 16.
      "Molecular forms of trefoil factor 1 in normal gastric mucosa and its expression in normal and abnormal gastric tissues."
      Ren J.L. , Luo J.-Y. , Lu Y.-P. , Wang L. , Shi H.-X.
      World J. Gastroenterol.12:7361-7364(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    16. 17.
      "Tissue localization of human trefoil factors 1, 2, and 3."
      Madsen J. , Nielsen O. , Tornoe I. , Thim L. , Holmskov U.
      J. Histochem. Cytochem.55:505-513(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    17. 18.
      "NMR-based structural studies of the pNR-2/pS2 single domain trefoil peptide. Similarities to porcine spasmolytic peptide and evidence for a monomeric structure."
      Polshakov V.I. , Frenkiel T.A. , Westley B.R. , Chadwick M.P. , May F.E.B. , Carr M.D. , Feeney J.
      Eur. J. Biochem.233:847-855(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    18. 19.
      "High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein."
      Polshakov V.I. , Williams M.A. , Gargaro A.R. , Frenkiel T.A. , Westley B.R. , Chadwick M.P. , May F.E.B. , Feeney J.
      J. Mol. Biol.267:418-432(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    19. 20.
      "Somatic mutations of the trefoil factor family 1 gene in gastric cancer."
      Park W.-S. , Oh R.-R. , Park J.-Y. , Lee J.-H. , Shin M.-S. , Kim H.-S. , Lee H.-K. , Kim Y.-S. , Kim S.-Y. , Lee S.-H. , Yoo N.-J. , Lee J.-Y.
      Gastroenterology119:691-698(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-32; LYS-32; ASP-34; LYS-37; ILE-46 AND VAL-55
    20. 21.
      "Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways."
      Yio X. , Diamond M. , Zhang J.-Y. , Weinstein H. , Wang L.-H. , Werther L. , Itzkowitz S.
      Gastroenterology130:1696-1706(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-34 AND LYS-37;MUTAGENESIS OF CYS-82
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