Protein name:
Transferrin receptor protein 1 (TR;TfR;TfR1;Trfr) ;
Alternative:
p90 ;T9 ;
CD:
CD71 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.
Function:
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Subcellular Location:
Transferrin receptor protein 1, serum form
Secreted
Protein Attributes:
50:
MMDQARSAFS | NLFGGEPLSY | TRFSLARQVD | GDNSHVEMKL | AVDEEENADN |
100:
NTKANVTKPK | RCSGSICYGT | IAVIVFFLIG | FMIGYLGYCK | GVEPKTECER |
150:
LAGTESPVRE | EPGEDFPAAR | RLYWDDLKRK | LSEKLDSTDF | TGTIKLLNEN |
200:
SYVPREAGSQ | KDENLALYVE | NQFREFKLSK | VWRDQHFVKI | QVKDSAQNSV |
250:
IIVDKNGRLV | YLVENPGGYV | AYSKAATVTG | KLVHANFGTK | KDFEDLYTPV |
300:
NGSIVIVRAG | KITFAEKVAN | AESLNAIGVL | IYMDQTKFPI | VNAELSFFGH |
350:
AHLGTGDPYT | PGFPSFNHTQ | FPPSRSSGLP | NIPVQTISRA | AAEKLFGNME |
400:
GDCPSDWKTD | STCRMVTSES | KNVKLTVSNV | LKEIKILNIF | GVIKGFVEPD |
450:
HYVVVGAQRD | AWGPGAAKSG | VGTALLLKLA | QMFSDMVLKD | GFQPSRSIIF |
500:
ASWSAGDFGS | VGATEWLEGY | LSSLHLKAFT | YINLDKAVLG | TSNFKVSASP |
550:
LLYTLIEKTM | QNVKHPVTGQ | FLYQDSNWAS | KVEKLTLDNA | AFPFLAYSGI |
600:
PAVSFCFCED | TDYPYLGTTM | DTYKELIERI | PELNKVARAA | AEVAGQFVIK |
650:
LTHDVELNLD | YERYNSQLLS | FVRDLNQYRA | DIKEMGLSLQ | WLYSARGDFF |
700:
RATSRLTTDF | GNAEKTDRFV | MKKLNDRVMR | VEYHFLSPYV | SPKESPFRHV |
750:
FWGSGSHTLP | ALLENLKLRK | QNNGAFNETL | FRNQLALATW | TIQGAANALS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Mouse
Rat
Chicken
Dog
Polyclonal Antibody for Human TR
Polyclonal Antibody for Human TR
Polyclonal Antibody for Human TR
Polyclonal Antibody for Human TR
Polyclonal Antibody for Human TR
Polyclonal Antibody for Human TR
Monoclonal Antibody for Human TR
Monoclonal Antibody for Human TR
Monoclonal Antibody for Human TR
Monoclonal Antibody for Human TR
Monoclonal Antibody for Human TR
Monoclonal Antibody for Human TR
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Qiurong Ding, Zhenzhen Wang and Yan Chen
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-142
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-142
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Placenta .
4.
"Molecular and evolutionary studies of the transferrin receptor."
Wheeler D.L.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Placenta .
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tissue :
Brain .
6.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Eye .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 101-123 (STFR);CHARACTERIZATION
tissue :
Erythroleukemia .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 288-302; 694-708 AND 721-730
tissue :
Prostatic carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF TYR-20
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERNALIZATION SEQUENCE;MUTAGENESIS OF TYR-20
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE OF CARBOHYDRATES ON ASN-727
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION OF LIGAND-BINDING DOMAIN
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF ARG-646; GLY-647 AND ASP-648
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SH3BP4
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-251
tissue :
Plasma .
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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PubMed ]
[
Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Melanoma .
29.
"Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses."
Radoshitzky S.R.
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Abraham J.
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Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MACHUPO ARENAVIRUS PROTEIN GPC
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-21;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-251 AND ASN-727
tissue :
Liver .
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-251
tissue :
Leukemic T-cell .
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Leukemic T-cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-20;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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37.
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38.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SER-142