Protein name:
Transferrin receptor protein 1 (TR;TfR;TfR1;Trfr) ;
Alternative:
CD:
CD71 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4.
Function:
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.
Subcellular Location:
Cell membrane
Single-pass type II membrane protein
Melanosome
Protein Attributes:
50:
MMDQARSAFS | NLFGGEPLSY | TRFSLARQVD | GDNSHVEMKL | AADEEENADN |
100:
NMKASVRKPK | RFNGRLCFAA | IALVIFFLIG | FMSGYLGYCK | RVEQKEECVK |
150:
LAETEETDKS | ETMETEDVPT | SSRLYWADLK | TLLSEKLNSI | EFADTIKQLS |
200:
QNTYTPREAG | SQKDESLAYY | IENQFHEFKF | SKVWRDEHYV | KIQVKSSIGQ |
250:
NMVTIVQSNG | NLDPVESPEG | YVAFSKPTEV | SGKLVHANFG | TKKDFEELSY |
300:
SVNGSLVIVR | AGEITFAEKV | ANAQSFNAIG | VLIYMDKNKF | PVVEADLALF |
350:
GHAHLGTGDP | YTPGFPSFNH | TQFPPSQSSG | LPNIPVQTIS | RAAAEKLFGK |
400:
MEGSCPARWN | IDSSCKLELS | QNQNVKLIVK | NVLKERRILN | IFGVIKGYEE |
450:
PDRYVVVGAQ | RDALGAGVAA | KSSVGTGLLL | KLAQVFSDMI | SKDGFRPSRS |
500:
IIFASWTAGD | FGAVGATEWL | EGYLSSLHLK | AFTYINLDKV | VLGTSNFKVS |
550:
ASPLLYTLMG | KIMQDVKHPV | DGKSLYRDSN | WISKVEKLSF | DNAAYPFLAY |
600:
SGIPAVSFCF | CEDADYPYLG | TRLDTYEALT | QKVPQLNQMV | RTAAEVAGQL |
650:
IIKLTHDVEL | NLDYEMYNSK | LLSFMKDLNQ | FKTDIRDMGL | SLQWLYSARG |
700:
DYFRATSRLT | TDFHNAEKTN | RFVMREINDR | IMKVEYHFLS | PYVSPRESPF |
750:
RHIFWGSGSH | TLSALVENLK | LRQKNITAFN | ETLFRNQLAL | ATWTIQGVAN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Mouse
Rat
Chicken
Dog
Polyclonal Antibody for Mouse TR
Polyclonal Antibody for Mouse TR
Polyclonal Antibody for Mouse TR
Polyclonal Antibody for Mouse TR
Polyclonal Antibody for Mouse TR
Polyclonal Antibody for Mouse TR
Monoclonal Antibody for Mouse TR
Monoclonal Antibody for Mouse TR
Monoclonal Antibody for Mouse TR
Monoclonal Antibody for Mouse TR
Monoclonal Antibody for Mouse TR
Monoclonal Antibody for Mouse TR
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6 X DBA/2 .
tissue :
Hematopoietic .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 25-301
tissue :
Myeloma .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 7-19; 158-179; 196-208; 450-467 AND 736-759
tissue :
Myeloma .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-20;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Mast cell .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-20;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-725 AND ASN-730