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Index > Protein center > Tfrc(Gene name) > Mouse
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  • Tfrc (Gene name),
  • Transferrin receptor protein 1 (Protein name ),  TFR1_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Tfrc(Trfr);
    Protein name:
    Transferrin receptor protein 1(TR;TfR;TfR1;Trfr);
    Alternative:

    CD:
    CD71;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4.
    Function:
    Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.
    Subcellular Location:
    Cell membrane Single-pass type II membrane protein Melanosome
    Protein Attributes:
    Sequence length:
    763
    Sequence:
    50:
    MMDQARSAFS | NLFGGEPLSY | TRFSLARQVD | GDNSHVEMKL | AADEEENADN | 
    100:
    NMKASVRKPK | RFNGRLCFAA | IALVIFFLIG | FMSGYLGYCK | RVEQKEECVK | 
    150:
    LAETEETDKS | ETMETEDVPT | SSRLYWADLK | TLLSEKLNSI | EFADTIKQLS | 
    200:
    QNTYTPREAG | SQKDESLAYY | IENQFHEFKF | SKVWRDEHYV | KIQVKSSIGQ | 
    250:
    NMVTIVQSNG | NLDPVESPEG | YVAFSKPTEV | SGKLVHANFG | TKKDFEELSY | 
    300:
    SVNGSLVIVR | AGEITFAEKV | ANAQSFNAIG | VLIYMDKNKF | PVVEADLALF | 
    350:
    GHAHLGTGDP | YTPGFPSFNH | TQFPPSQSSG | LPNIPVQTIS | RAAAEKLFGK | 
    400:
    MEGSCPARWN | IDSSCKLELS | QNQNVKLIVK | NVLKERRILN | IFGVIKGYEE | 
    450:
    PDRYVVVGAQ | RDALGAGVAA | KSSVGTGLLL | KLAQVFSDMI | SKDGFRPSRS | 
    500:
    IIFASWTAGD | FGAVGATEWL | EGYLSSLHLK | AFTYINLDKV | VLGTSNFKVS | 
    550:
    ASPLLYTLMG | KIMQDVKHPV | DGKSLYRDSN | WISKVEKLSF | DNAAYPFLAY | 
    600:
    SGIPAVSFCF | CEDADYPYLG | TRLDTYEALT | QKVPQLNQMV | RTAAEVAGQL | 
    650:
    IIKLTHDVEL | NLDYEMYNSK | LLSFMKDLNQ | FKTDIRDMGL | SLQWLYSARG | 
    700:
    DYFRATSRLT | TDFHNAEKTN | RFVMREINDR | IMKVEYHFLS | PYVSPRESPF | 
    750:
    RHIFWGSGSH | TLSALVENLK | LRQKNITAFN | ETLFRNQLAL | ATWTIQGVAN | 
    763:
    ALSGDIWNID | NEF
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse TR
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    E0809h
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    ELISA Kit for Mouse TR
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    E0809p
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    ELISA Kit for Mouse TR
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    E0809m
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    ELISA Kit for Mouse TR
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    E0809r
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    ELISA Kit for Mouse TR
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    E0809c
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    96T
    ELISA Kit for Mouse TR
    Cat.:
    E0809d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse TR
    Cat.:
    U0809c
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    Packing:
    96T
    CLIA Kit for Mouse TR
    Cat.:
    U0809p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse TR
    Cat.:
    U0809h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse TR
    Cat.:
    U0809r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse TR
    Cat.:
    U0809d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse TR
    Cat.:
    U0809m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse TR
    Polyclonal Antibody for Mouse TR
    Polyclonal Antibody for Mouse TR
    Cat.:
    P0809Rb-m
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse TR
    Cat.:
    P0809Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse TR
    Polyclonal Antibody for Mouse TR
    Cat.:
    P0809Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse TR
    Monoclonal Antibody for Mouse TR
    Monoclonal Antibody for Mouse TR
    Monoclonal Antibody for Mouse TR
    Monoclonal Antibody for Mouse TR
    Monoclonal Antibody for Mouse TR
    Protein for Mouse TR
    Protein for Mouse TR
    Protein for Mouse TR
    Protein for Mouse TR
    Protein for Mouse TR
    Protein for Mouse TR

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    References
    1. 1.
      Trowbridge I.S. , Domingo D.L. , Thomas M.L. , Chain A.
      Submitted (1991-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6 X DBA/2.
      tissue: Hematopoietic.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    3. 3.
      "cDNA cloning of the murine transferrin receptor: sequence of trans-membrane and adjacent regions."
      Stearne P.A. , Pietersz G.A. , Goding J.W.
      J. Immunol.134:3474-3479(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-301
      tissue: Myeloma.
    4. 4.
      "The receptor for transferrin on murine myeloma cells: one-step purification based on its physiology, and partial amino acid sequence."
      van Driel I.R. , Stearne P.A. , Grego B. , Simpson R.J. , Goding J.W.
      J. Immunol.133:3220-3224(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 7-19; 158-179; 196-208; 450-467 AND 736-759
      tissue: Myeloma.
    5. 5.
      "Transferrin receptor is necessary for development of erythrocytes and the nervous system."
      Levy J.E. , Jin O. , Fujiwara Y. , Kuo F. , Andrews N.C.
      Nat. Genet.21:396-399(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
      J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-20;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Mast cell.
    7. 7.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-20;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    8. 8.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-725 AND ASN-730
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