Protein name:
Transforming growth factor beta-1 (TGF-beta-1) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
The inactive form consists of a TGFB1 homodimer non-covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT. Interacts with ASPN.
Function:
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MPPSGLRLLL | LLLPLLWLLV | LTPGRPAAGL | STCKTIDMEL | VKRKRIEAIR |
100:
GQILSKLRLA | SPPSQGEVPP | GPLPEAVLAL | YNSTRDRVAG | ESAEPEPEPE |
150:
ADYYAKEVTR | VLMVETHNEI | YDKFKQSTHS | IYMFFNTSEL | REAVPEPVLL |
200:
SRAELRLLRL | KLKVEQHVEL | YQKYSNNSWR | YLSNRLLAPS | DSPEWLSFDV |
250:
TGVVRQWLSR | GGEIEGFRLS | AHCSCDSRDN | TLQVDINGFT | TGRRGDLATI |
300:
HGMNRPFLLL | MATPLERAQH | LQSSRHRRAL | DTNYCFSSTE | KNCCVRQLYI |
350:
DFRKDLGWKW | IHEPKGYHAN | FCLGPCPYIW | SLDTQYSKVL | ALYNQHNPGA |
390:
SAAPCCVPQA | LEPLPIVYYV | GRKPKVEQLS | NMIVRSCKCS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
Pig
Dog
Chicken
Rat
ELISA Kit for Human TGF-beta-1
ELISA Kit for Human TGF-beta-1
ELISA Kit for Human TGF-beta-1
ELISA Kit for Human TGF-beta-1
ELISA Kit for Human TGF-beta-1
ELISA Kit for Human TGF-beta-1
ELISA Kit for Human TGF-beta-1
CLIA Kit for Human TGF-beta-1
CLIA Kit for Human TGF-beta-1
CLIA Kit for Human TGF-beta-1
CLIA Kit for Human TGF-beta-1
CLIA Kit for Human TGF-beta-1
CLIA Kit for Human TGF-beta-1
CLIA Kit for Human TGF-beta-1
Polyclonal Antibody for Human TGF-beta-1
Polyclonal Antibody for Human TGF-beta-1
Polyclonal Antibody for Human TGF-beta-1
Polyclonal Antibody for Human TGF-beta-1
Polyclonal Antibody for Human TGF-beta-1
Polyclonal Antibody for Human TGF-beta-1
Polyclonal Antibody for Human TGF-beta-1
Monoclonal Antibody for Human TGF-beta-1
Monoclonal Antibody for Human TGF-beta-1
Monoclonal Antibody for Human TGF-beta-1
Monoclonal Antibody for Human TGF-beta-1
Monoclonal Antibody for Human TGF-beta-1
Monoclonal Antibody for Human TGF-beta-1
Monoclonal Antibody for Human TGF-beta-1
Protein for Human TGF-beta-1
Protein for Human TGF-beta-1
Protein for Human TGF-beta-1
Protein for Human TGF-beta-1
Protein for Human TGF-beta-1
Protein for Human TGF-beta-1
Protein for Human TGF-beta-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[2].
Y Abe, M Murano, N Murano, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANTS PRO-10 AND PRO-25
3.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
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Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
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Suzuki Y.
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.
Mural R.J.
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Istrail S.
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Sutton G.G.
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,
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Duodenum .
tissue :
Eye .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 279-390
tissue :
Carcinoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 279-329
tissue :
Urinary bladder carcinoma .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 279-301
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 30-42 AND 279-290;CHARACTERIZATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DPT
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-82
tissue :
Plasma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CD109
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-82
tissue :
Platelet .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH ASPN
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
"Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells."
Archer S.J.
,
Bax A.
,
Roberts A.B.
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Torchia D.A.
Biochemistry32:1152-1163(1993)
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PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 279-390
20.
"Transforming growth factor beta 1: secondary structure as determined by heteronuclear magnetic resonance spectroscopy."
Archer S.J.
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Bax A.
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Roberts A.B.
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Sporn M.B.
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Ogawa Y.
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Piez K.A.
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Weatherbee J.A.
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Torchia D.A.
Biochemistry32:1164-1171(1993)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 279-390
21.
"Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2."
Hinck A.P.
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Archer S.J.
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Qian S.W.
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Roberts A.B.
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Sporn M.B.
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Weatherbee J.A.
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Lucas R.
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Torchia D.A.
Biochemistry35:8517-8534(1996)
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 279-390
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PRO-10
23.
"Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease."
Kinoshita A.
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Saito T.
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Tomita H.
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Makita Y.
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Yoshida K.
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Ghadami M.
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Yamada K.
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Kondo S.
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Ikegawa S.
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Nakagomi T.
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Kamegaya M.
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Murray J.C.
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Nat. Genet.26:19-20(2000)
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Cited for : VARIANTS CE CYS-218; HIS-218 AND ARG-225
24.
"Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause Camurati-Engelmann disease."
Janssens K.
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Gershoni-Baruch R.
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Guanabens N.
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Migone N.
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Ralston S.
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Bonduelle M.
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Nat. Genet.26:273-275(2000)
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PubMed ]
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Cited for : VARIANTS CE HIS-81; CYS-218 AND ARG-225
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PRO-10
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF VARIANTS CE HIS-81; CYS-218; ASP-222 AND ARG-225
27.
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Cited for : CHARACTERIZATION OF VARIANT CE CYS-218
28.
"TGFB1 mutations in four new families with Camurati-Engelmann disease: confirmation of independently arising LAP-domain-specific mutations."
Kinoshita A.
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Fukumaki Y.
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Shirahama S.
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Miyahara A.
,
Nishimura G.
,
Haga N.
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Namba A.
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Ueda H.
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Hayashi H.
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Ikegawa S.
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Seidel J.
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Yoshiura K.
Am. J. Med. Genet.127A:104-107(2004)
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Europe PMC ]
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Cited for : VARIANTS CE GLY-223 AND ARG-223