Protein name:
Thioredoxin (Trx) ;
Alternative:
ATL-derived factor (ADF) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner.
Function:
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
Subcellular Location:
Nucleus
Cytoplasm
Secreted
Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.
Protein Attributes:
50:
MVKLIESKEA | FQEALAAAGD | KLVVVDFSAT | WCGPCKMIKP | FFHSLCDKYS |
100:
NVVFLEVDVD | DCQDVAADCE | VKCMPTFQFY | KKGQKVGEFS | GANKEKLEAS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Human
Rat
Pig
Mouse
Chicken
Rabbit
Bovine
Polyclonal Antibody for Mouse Trx
Polyclonal Antibody for Mouse Trx
Polyclonal Antibody for Mouse Trx
Polyclonal Antibody for Mouse Trx
Polyclonal Antibody for Mouse Trx
Polyclonal Antibody for Mouse Trx
Polyclonal Antibody for Mouse Trx
Polyclonal Antibody for Mouse Trx
Monoclonal Antibody for Mouse Trx
Monoclonal Antibody for Mouse Trx
Monoclonal Antibody for Mouse Trx
Monoclonal Antibody for Mouse Trx
Monoclonal Antibody for Mouse Trx
Monoclonal Antibody for Mouse Trx
Monoclonal Antibody for Mouse Trx
Monoclonal Antibody for Mouse Trx
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction."
Tagaya Y.
,
Maeda Y.
,
Mitsui A.
,
Kndo N.
,
Matsui H.
,
Hamuro J.
,
Brown N.
,
Arai K.
,
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,
Wakasugi H.
,
Yodoi J.
EMBO J.8:757-764(1989)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
Tagaya Y.
,
Maeda Y.
,
Mitsui A.
,
Kndo N.
,
Matsui H.
,
Hamuro J.
,
Brown N.
,
Arai K.
,
Yokota T.
,
Wakasugi H.
,
Yodoi J.
EMBO J.13:2244-2244(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM;SEQUENCE REVISION
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
129/Sv .
tissue :
Liver .
4.
"The transcriptional landscape of the mammalian genome."
Carninci P.
,
Kasukawa T.
,
Katayama S.
,
Gough J.
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Frith M.C.
,
Maeda N.
,
Oyama R.
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Bersano T.
,
Bono H.
,
Chalk A.M.
,
Chiu K.P.
,
Choudhary V.
,
Christoffels A.
,
Clutterbuck D.R.
,
Crowe M.L.
,
Dalla E.
,
Dalrymple B.P.
,
de Bono B.
,
Della Gatta G.
,
di Bernardo D.
,
Down T.
,
Engstrom P.
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Fagiolini M.
,
Faulkner G.
,
Fletcher C.F.
,
Fukushima T.
,
Furuno M.
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Futaki S.
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Gariboldi M.
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Gingeras T.R.
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Green R.E.
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Hayashi Y.
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Iwama A.
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Jakt M.
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Kanapin A.
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Katoh M.
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Kawasawa Y.
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Kelso J.
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Kitamura H.
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Miki H.
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Mignone F.
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Ng P.
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Orlando V.
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Pang K.C.
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Pesole G.
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Ruan Y.
,
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,
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Semple C.A.
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Sessa L.
,
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,
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,
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,
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,
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,
Sinclair B.
,
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,
Stupka E.
,
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,
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,
Takenaka Y.
,
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,
Tammoja K.
,
Tan S.L.
,
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,
Taylor M.S.
,
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,
Teichmann S.A.
,
Ueda H.R.
,
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,
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,
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,
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,
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,
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Pancreas .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Colon .
tissue :
Thymus .
6.
"Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function."
Junn E.
,
Han S.H.
,
Im J.Y.
,
Yang Y.
,
Cho E.W.
,
Um H.D.
,
Kim D.K.
,
Lee K.W.
,
Han P.L.
,
Rhee S.G.
,
Choi I.
J. Immunol.164:6287-6295(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TXNIP
7.
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J.
,
Chen Y.
,
Tishkoff D.X.
,
Peng C.
,
Tan M.
,
Dai L.
,
Xie Z.
,
Zhang Y.
,
Zwaans B.M.
,
Skinner M.E.
,
Lombard D.B.
,
Zhao Y.
Mol. Cell50:919-930(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-39 AND LYS-94;SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-8 AND LYS-94;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
tissue :
Liver .