Protein name:
Thioredoxin (Trx) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner.
Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Subcellular Location:
Nucleus
Cytoplasm
Secreted
Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.
Protein Attributes:
50:
MVKLIESKEA | FQEALAAAGD | KLVVVDFSAT | WCGPCKMIKP | FFHSLCDKYS |
100:
NVVFLEVDVD | DCQDVAADCE | VKCMPTFQFY | KKGQKVGEFS | GANKEKLEAT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Human
Rat
Pig
Mouse
Chicken
Rabbit
Bovine
Polyclonal Antibody for Rat Trx
Polyclonal Antibody for Rat Trx
Polyclonal Antibody for Rat Trx
Polyclonal Antibody for Rat Trx
Polyclonal Antibody for Rat Trx
Polyclonal Antibody for Rat Trx
Polyclonal Antibody for Rat Trx
Polyclonal Antibody for Rat Trx
Monoclonal Antibody for Rat Trx
Monoclonal Antibody for Rat Trx
Monoclonal Antibody for Rat Trx
Monoclonal Antibody for Rat Trx
Monoclonal Antibody for Rat Trx
Monoclonal Antibody for Rat Trx
Monoclonal Antibody for Rat Trx
Monoclonal Antibody for Rat Trx
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Pituitary .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-21
tissue :
Glial cell .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 9-21; 73-81 AND 86-94;IDENTIFICATION BY MASS SPECTROMETRY
strain :
Sprague-Dawley .
tissue :
Brain .
tissue :
Hippocampus .