TG ELISA Kit for Human(Homo sapiens) | EIAab.comTG ELISA Kit for Human(Homo sapiens)

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Index > Protein center > TG(Gene name) > Human

TG (Gene name),

Thyroglobulin (Protein name ), THYG_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TG;

Protein name:

Thyroglobulin(Tg);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

2768

Sequence:

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2400:

2450:

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2550:

2600:

2650:

2700:

2750:

2768:

LREDLLSLQE | PGSKTYSK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.654591

SMR:

P01266

Pfam:

PF00135

KEGG:

hsa:7038

MIM:

188450

String:

P01266

Uniprot:

P01266

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ELISA Kit for Human Tg

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E0355h

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ELISA Kit for Human Tg

Cat.:

E0355r

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96T

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ELISA Kit for Human Tg

Cat.:

E0355m

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96T

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ELISA Kit for Human Tg

Cat.:

E0355b

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96T

ELISA Kit for Human Tg

Cat.:

E0355p

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96T

CLIA Kit for Human Tg

Cat.:

U0355p

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96T

CLIA Kit for Human Tg

Cat.:

U0355r

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96T

CLIA Kit for Human Tg

Cat.:

U0355h

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96T

CLIA Kit for Human Tg

Cat.:

U0355b

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96T

CLIA Kit for Human Tg

Cat.:

U0355m

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96T

Polyclonal Antibody for Human Tg

Cat.:

P0355Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Tg

Cat.:

P0355Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Tg

Cat.:

P0355Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Tg

Monoclonal Antibody for Human Tg

Protein for Human Tg

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
Saliva(n=3)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA."
Malthiery Y. , Lissitzky S.
Eur. J. Biochem.165:491-498(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ASP-604; ASP-653; GLN-985 DEL; TYR-1043; THR-1059; GLY-1312; ARG-1437; HIS-1463; THR-1936; GLU-2091; LEU-2149; ARG-2170 AND HIS-2242
2.

"The revised 8307 base pair coding sequence of human thyroglobulin transiently expressed in eukaryotic cells."
van de Graaf S.A.R. , Pauws E. , de Vijlder J.J.M. , Ris-Stalpers C.
Eur. J. Endocrinol.136:508-515(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-1312
tissue: Thyroid.
3.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLU-515
4.

"Sequence of the 5'-end quarter of the human-thyroglobulin messenger ribonucleic acid and of its deduced amino-acid sequence."
Malthiery Y. , Lissitzky S.
Eur. J. Biochem.147:53-58(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-730;VARIANTS ASP-604 AND ASP-653
5.

"Structural organization of the 5' region of the thyroglobulin gene. Evidence for intron loss and 'exonization' during evolution."
Parma J. , Christophe D. , Pohl V. , Vassart G.
J. Mol. Biol.196:769-779(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-415; 640-737 AND 880-1000;VARIANT ALA-734
6.

"An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene."
Christophe D. , Cabrer B. , Bacolla A. , Targovnik H.M. , Pohl V. , Vassart G.
Nucleic Acids Res.13:5127-5144(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25
7.

"Genomic organization of the 5' region of the human thyroglobulin gene."
Moya C.M. , Mendive F.M. , Rivolta C.M. , Vassart G. , Targovnik H.M.
Eur. J. Endocrinol.143:789-798(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1002-1566 (ISOFORM 1);VARIANT GLY-1312
8.

"Genomic organization of the 3' region of the human thyroglobulin gene."
Mendive F.M. , Rivolta C.M. , Vassart G. , Targovnik H.M.
Thyroid9:903-912(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1645-2768;VARIANTS LEU-2149 AND ARG-2170
9.

"Identification of a minor Tg mRNA transcript in RNA from normal and goitrous thyroids."
Targovnik H.M. , Cochaux P. , Corach D. , Vassart G.
Mol. Cell. Endocrinol.84:R23-R26(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1504-1602 (ISOFORM 2)
10.

"Hormone synthesis in human thyroglobulin: possible cleavage of the polypeptide chain at the tyrosine donor site."
Marriq C. , Lejeune P.J. , Venot N. , Vinet L.
FEBS Lett.242:414-418(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
11.

"Preferential sites of proteolytic cleavage of bovine, human and rat thyroglobulin. The use of limited proteolysis to detect solvent-exposed regions of the primary structure."
Gentile F. , Salvatore G.
Eur. J. Biochem.218:603-621(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
12.

"Characterization of hormonogenic sites in an N-terminal, cyanogen bromide fragment of human thyroglobulin."
Xiao S. , Pollock H.G. , Taurog A. , Rawitch A.B.
Arch. Biochem. Biophys.320:96-105(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
13.

"Glycosylation in human thyroglobulin: location of the N-linked oligosaccharide units and comparison with bovine thyroglobulin."
Yang S.X. , Pollock H.G. , Rawitch A.B.
Arch. Biochem. Biophys.327:61-70(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION AT ASN-76; ASN-198; ASN-484; ASN-529; ASN-748; ASN-816; ASN-947; ASN-1220; ASN-1348; ASN-1349; ASN-1365; ASN-1716; ASN-1774; ASN-2013; ASN-2250; ASN-2295 AND ASN-2582;ABSENCE OF GLYCOSYLATION AT ASN-110; ASN-496; ASN-1869 AND ASN-2122
14.

"Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families."
Molina F. , Bouanani M. , Pau B. , Granier C.
Eur. J. Biochem.240:125-133(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRESENCE OF A 11TH TYROGLOBULIN TYPE-1 REPEAT
15.

"Consensus sequences for early iodination and hormonogenesis in human thyroglobulin."
Lamas L. , Anderson P.C. , Fox J.W. , Dunn J.T.
J. Biol. Chem.264:13541-13545(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IODINATION AT TYR-24; TYR-1310; TYR-2573; TYR-2587 AND TYR-2766
16.

"Sulfated tyrosines of thyroglobulin are involved in thyroid hormone synthesis."
Nlend M.-C. , Cauvi D. , Venot N. , Chabaud O.
Biochem. Biophys. Res. Commun.262:193-197(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION
17.

"The hormonogenic tyrosine 5 of porcine thyroglobulin is sulfated."
Venot N. , Nlend M.-C. , Cauvi D. , Chabaud O.
Biochem. Biophys. Res. Commun.298:193-197(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION AT TYR-24
18.

"A single chondroitin 6-sulfate oligosaccharide unit at Ser-2730 of human thyroglobulin enhances hormone formation and limits proteolytic accessibility at the carboxyl terminus. Potential insights into thyroid homeostasis and autoimmunity."
Conte M. , Arcaro A. , D'Angelo D. , Gnata A. , Mamone G. , Ferranti P. , Formisano S. , Gentile F.
J. Biol. Chem.281:22200-22211(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-2749
19.

"Thyroglobulin gene point mutation associated with non-endemic simple goitre."
Corral J. , Martin C. , Perez R. , Sanchez I. , Mories M.T. , San Millan J.L. , Miralles J.M. , Gonzalez-Sarmiento R.
Lancet341:462-464(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-870
20.

"Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter."
Hishinuma A. , Takamatsu J. , Ohyama Y. , Yokozawa T. , Kanno Y. , Kuma K. , Yoshida S. , Matsuura N. , Ieiri T.
J. Clin. Endocrinol. Metab.84:1438-1444(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH3 ARG-1264 AND SER-1996;VARIANTS HIS-135; ASP-604; ASP-653; ALA-734; GLU-830; GLN-985 DEL; VAL-1028; TYR-1043; THR-1059; ARG-1437; HIS-1463; ASN-1838; THR-1936; TRP-1999; GLU-2091; LEU-2149; ARG-2170; HIS-2242; ARG-2501 AND GLN-2530
21.

"Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease."
Ban Y. , Greenberg D.A. , Concepcion E. , Skrabanek L. , Villanueva R. , Tomer Y.
Proc. Natl. Acad. Sci. U.S.A.100:15119-15124(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-734; VAL-1028 AND TRP-1979;INVOLVEMENT IN AITD3
22.

"A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels."
Kitanaka S. , Takeda A. , Sato U. , Miki Y. , Hishinuma A. , Ieiri T. , Igarashi T.
J. Hum. Genet.51:379-382(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH3 TYR-1897 AND GLN-2336
23.

"Congenital hypothyroidism with goitre caused by new mutations in the thyroglobulin gene."
Caputo M. , Rivolta C.M. , Esperante S.A. , Gruneiro-Papendieck L. , Chiesa A. , Pellizas C.G. , Gonzalez-Sarmiento R. , Targovnik H.M.
Clin. Endocrinol. (Oxf.)67:351-357(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TDH3 TYR-183 AND ASP-2234
24.

"Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity."
Kanou Y. , Hishinuma A. , Tsunekawa K. , Seki K. , Mizuno Y. , Fujisawa H. , Imai T. , Miura Y. , Nagasaka T. , Yamada C. , Ieiri T. , Murakami M. , Murata Y.
J. Clin. Endocrinol. Metab.92:1451-1457(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH3 ARG-2375
25.

"The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation."
Pardo V. , Vono-Toniolo J. , Rubio I.G. , Knobel M. , Possato R.F. , Targovnik H.M. , Kopp P. , Medeiros-Neto G.
J. Clin. Endocrinol. Metab.94:2938-2944(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TDH3 ASP-2234;CHARACTERIZATION OF VARIANT TDH3 ASP-2234

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