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Index > Protein center > Tg(Gene name) > Rat
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  • Tg (Gene name),
  • Thyroglobulin (Protein name ),  THYG_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (2)
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  • Gene name:
    Tg;
    Protein name:
    Thyroglobulin(Tg);
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    2768
    Sequence:
    50:
    MMTLVLWVST | LLSSVCLVAA | NIFEYQVDAQ | PLRPCELQRE | KAFLKQDEYV | 
    100:
    PQCSEDGSFQ | TVQCQNDGQS | CWCVDSDGTE | VPGSRQLGRP | TACLSFCQLH | 
    150:
    KQRILLSSYI | NSTDALYLPQ | CQDSGNYAPV | QCDLQQVQCW | CVDTEGMEVY | 
    200:
    GTRQQGRPTR | CPRSCEIRSR | RLLHGVGDKS | PPQCDADGEF | MPVQCKFVNT | 
    250:
    TDMMIFDLIH | NYNRFPDAFV | TFSAFRNRFP | EVSGYCYCAD | SQGRELAETG | 
    300:
    LELLLDEIYD | TIFAGLDQAS | TFTQSTMYRI | LQRRFLAIQL | VISGRFRCPT | 
    350:
    KCEVEQFTAT | SFGHPYIPSC | HRDGHYQTVQ | CQMERMCWCV | DAQGIEIPGT | 
    400:
    RQQGQPLFCA | KDQSCASERQ | QALSRLYFET | PGYFSPQDLL | SSEDRLVPVS | 
    450:
    GARLDISCPP | RIKELFVDSG | LLRSIAVERY | QQLSESRSLL | REAIRAIFPS | 
    500:
    RELAGLALQF | TTNPKRLQQN | LFGGTFLVNA | AQLNLSGALG | TRSTFNFSQF | 
    550:
    FQQFGLPGFL | VRDRATDLAK | LLPVSLDSSP | TPVPLRVPEK | RVAMNKSVVG | 
    600:
    TFGFKVNLQE | NQDALKFLVS | LMELPEFLVF | LQRAVSVPED | RARDLGDVME | 
    650:
    MVFSAQACKQ | TSGRFFVPSC | TAEGSYEDIQ | CYAGECWCVN | SQGKEVEGSR | 
    700:
    VSGGHPRCPT | KCEKQRAQMQ | NLAGAQPAGS | SFFVPTCTSE | GYFLPVQCFN | 
    750:
    SECYCVDAEG | QVIPGTQSTI | GEPKLCPSVC | QLQAEQAFLG | VVGVLLSNSS | 
    800:
    MVPPISSVYI | PQCSTSGQWM | PVQCDGPHEQ | VFEWYERWNT | QNSDGQELTT | 
    850:
    ATLLMKLMSY | REVASTNFSL | FLQSLYDAGQ | QSIFPVLAQY | PSLQDVPQVV | 
    900:
    LEGATIQPGE | NIFLDPYIFW | QILNGQLSQY | PGPYSDFSMP | LEHFNLRSCW | 
    950:
    CVDEAGQELD | GTRTRAGEIP | ACPGPCEEVK | FRVLKFIKET | EEIVSASNAS | 
    1000:
    SFPLGESFLV | AKGIQLTSEE | LGLPPLYPSR | EAFSEKFLRG | SEYAIRLAAQ | 
    1050:
    STLTFYQKLR | ASLGESNGTA | SLLWSGPYMP | QCNTIGGWEP | VQCHPGTGQC | 
    1100:
    WCVDGWGELI | PGSLMARSSQ | MPQCPTSCEL | SRANGLISAW | KQAGHQRNPG | 
    1150:
    PGDLFTPVCL | QTGEYVRQQT | SGTGAWCVDP | SSGEGVPTNT | NSSAQCPGLC | 
    1200:
    DALKSRVLSR | KVGLGYTPVC | EALDGGFSPV | QCDLAQGSCW | CVLASGEEVP | 
    1250:
    GTRVVGTQPA | CESPQCPLPF | SGSDVTDGVV | FCETASSSGV | TTVQQCQLFC | 
    1300:
    RQGLRNVFSP | GPLICNLESQ | RWVTLPLPRA | CQRPQLWQTM | QTQAHFQLLL | 
    1350:
    PPGKMCSIDY | SGLLQAFQVF | ILDELITRGF | CQIQVKTFGT | LVSRTVCDNS | 
    1400:
    SIQVGCLTAE | RLGVNATWKL | QLEDISVGSL | PNLHSIERAL | MGQDLLGRFA | 
    1450:
    NLIQSGKFQL | HLDSKTFSAD | TILYFLNGDR | FVTSPMTQLG | CLEGFYRVST | 
    1500:
    TSQDPLGCVK | CPEGSFSQDG | KCTPCPAGTY | QGQAGSSACI | PCPRGRTTTI | 
    1550:
    TGAFSKTHCV | TDCQRDEAGL | QCDQNGQYQA | NQKDMDSGEV | FCVDSEGQRL | 
    1600:
    QWLQTEAGLS | ESQCLMMRKF | EKAPESKVIF | DASSPVIVKS | RVPSANSPLV | 
    1650:
    QCLADCADDE | ACSFVTVSSM | SSEVSCDLYS | WTRDNFACVT | SDQEEDAVDS | 
    1700:
    LKETSFGSLR | CQVKVRNSGK | DSLAVYVKKG | HEFTASGQKS | FEPTGFQNVL | 
    1750:
    SGLYSSVVFS | ALGTNLTDTH | LFCLLACDQD | SCCDGFIVTQ | VKEGPTICGL | 
    1800:
    LSAPDILVCH | INDWRDASDT | QANGTCAGVT | YDQGSRQMTM | SLGGQEFLQG | 
    1850:
    LTLLEGTQDS | FISFQQVYLW | KDSDIGSRPE | SMGCGRGMVP | KSEAPEGADM | 
    1900:
    ATELFSPVDI | TQVIVNTSHS | LPSQQYWLST | HLFSAEQANL | WCLSRCAQEP | 
    1950:
    VFCQLADIME | SSSLYFTCSL | YPEAQVCDND | VESNAKNCSQ | ILPRQPTALF | 
    2000:
    QRKVVLNDRV | KNFYTRLPFQ | KLSGISIRDR | IPMSEKLISN | GFFECERLCD | 
    2050:
    RDPCCTGFGF | LNVSQMQGGE | MTCLTLNSMG | IQTCSEENGA | TWRILDCGSE | 
    2100:
    DTEVHTYPFG | WYQKPAVWSD | APSFCPSAAL | QSLTEEKVAL | DSWQTLALSS | 
    2150:
    VIIDPSIKHF | DVAHISISAT | RNFSLAQDFC | LQECSRHQDC | LVTTLQIQQG | 
    2200:
    VVRCVFYPDI | QSCEHSLRSK | TCWLLLHEEA | AYIYRKSGAP | LHQSDGISTP | 
    2250:
    SVHIDSFGQL | QGGSQVVKVG | TAWKQVYQFL | GVPYAAPPLA | ENRFQAPEVL | 
    2300:
    NWTGSWDATK | LRSSCWQPGT | RTPTPPQISE | DCLYLNVFVP | ENLVSNASVL | 
    2350:
    VFFHNTVEME | GSGGQLNIDG | SILAAVGNLI | VVTANYRLGV | FGFLSSGSDE | 
    2400:
    VAGNWGLLDQ | VAALTWVQTH | IGAFGGDPQR | VTLAADRGGA | DVASIHLLIT | 
    2450:
    RPTRLQLFRK | ALLMGGSALS | PAAIISPDRA | QQQAAALAKE | VGCPNSSVQE | 
    2500:
    VVSCFRQKPA | NILNEAQTKL | LAVSGPFHYW | GPVVDGQYLR | ELPSRRLKRP | 
    2550:
    LPVKVDLLIG | GSQDDGLINR | AKAVKQFEES | QGRTNSKTAF | YQALQNSLGG | 
    2600:
    EDSDARILAA | AIWYYSLEHS | TDDYASFSRA | LENATRDYFI | ICPIVNMASL | 
    2650:
    WARRTRGNVF | MYHVPESYGH | GSLELLADVQ | YAFGLPFYSA | YQGYFSTEEQ | 
    2700:
    SLSLKVMQYF | SNFIRSGNPN | YPHEFSQKAA | EFATPWPDFV | PGAGGESYKE | 
    2750:
    LSAQLPNRQG | LKKADCSFWS | KYIQTLKDAD | GAKDAQLTKS | GEEDLEVGPG | 
    2768:
    SEEDFSGSLE | PVPKSYSK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
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    CLIA Kit for Rat Tg
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    Polyclonal Antibody for Rat Tg
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    P0355Rb-h
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    Polyclonal Antibody for Rat Tg
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    Polyclonal Antibody for Rat Tg
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    Packing:
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    Polyclonal Antibody for Rat Tg
    Polyclonal Antibody for Rat Tg
    Monoclonal Antibody for Rat Tg
    Monoclonal Antibody for Rat Tg
    Monoclonal Antibody for Rat Tg
    Monoclonal Antibody for Rat Tg
    Monoclonal Antibody for Rat Tg
    Protein for Rat Tg
    Protein for Rat Tg
    Protein for Rat Tg
    Protein for Rat Tg
    Protein for Rat Tg

    R&D Technical Data
    s
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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

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    Recovery

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    Saliva(n=3)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

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    References
    1. 1.
      "A novel missense mutation (G2320R) in thyroglobulin causes hypothyroidism in rdw rats."
      Hishinuma A. , Furudate S. , Oh-Ishi M. , Nagakubo N. , Namatame T. , Ieiri T.
      Endocrinology141:4050-4055(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT HYPOTHYROIDISM ARG-2320
      strain: Wistar Imamichi.
    2. 2.
      "A missense mutation in the thyroglobulin gene causes hypothyroidism and dwarfism not associated with goiter in the WIC-rdw rat."
      Ding M. , Jung C.-C. , Cheng J.-M. , Miyamoto T. , Furudate S.I. , Agui T.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Fischer 344.
    3. 3.
      "A second thyroglobulin messenger RNA species (rTg-2) in rat thyrocytes."
      Graves P.N. , Davies T.F.
      Mol. Endocrinol.4:155-161(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-213
      strain: Fischer.
      tissue: Thymocyte.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-59
    5. 5.
      "The sequence of 967 amino acids at the carboxyl-end of rat thyroglobulin. Location and surroundings of two thyroxine-forming sites."
      di Lauro R. , Obici S. , Condliffe D. , Ursini V.M. , Musti A.M. , Moscatelli C. , Avvedimento V.E.
      Eur. J. Biochem.148:7-11(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1802-2768
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