"Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta."
Ziegler S.F. , Bird T.A. , Schneringer J.A. , Schooley K.A. , Baum P.R.
Oncogene8:663-670(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , Yamamoto J. , Saito K. , Kawai Y. , Isono Y. , Nakamura Y. , Nagahari K. , Murakami K. , Yasuda T. , Iwayanagi T. , Wagatsuma M. , Shiratori A. , Sudo H. , Hosoiri T. , Kaku Y. , Kodaira H. , Kondo H. , Sugawara M. , Takahashi M. , Kanda K. , Yokoi T. , Furuya T. , Kikkawa E. , Omura Y. , Abe K. , Kamihara K. , Katsuta N. , Sato K. , Tanikawa M. , Yamazaki M. , Ninomiya K. , Ishibashi T. , Yamashita H. , Murakawa K. , Fujimori K. , Tanai H. , Kimata M. , Watanabe M. , Hiraoka S. , Chiba Y. , Ishida S. , Ono Y. , Takiguchi S. , Watanabe S. , Yosida M. , Hotuta T. , Kusano J. , Kanehori K. , Takahashi-Fujii A. , Hara H. , Tanase T.-O. , Nomura Y. , Togiya S. , Komai F. , Hara R. , Takeuchi K. , Arita M. , Imose N. , Musashino K. , Yuuki H. , Oshima A. , Sasaki N. , Aotsuka S. , Yoshikawa Y. , Matsunawa H. , Ichihara T. , Shiohata N. , Sano S. , Moriya S. , Momiyama H. , Satoh N. , Takami S. , Terashima Y. , Suzuki O. , Nakagawa S. , Senoh A. , Mizoguchi H. , Goto Y. , Shimizu F. , Wakebe H. , Hishigaki H. , Watanabe T. , Sugiyama A. , Takemoto M. , Kawakami B. , Yamazaki M. , Watanabe K. , Kumagai A. , Itakura S. , Fukuzumi Y. , Fujimori Y. , Komiyama M. , Tashiro H. , Tanigami A. , Fujiwara T. , Ono T. , Yamada K. , Fujii Y. , Ozaki K. , Hirao M. , Ohmori Y. , Kawabata A. , Hikiji T. , Kobatake N. , Inagaki H. , Ikema Y. , Okamoto S. , Okitani R. , Kawakami T. , Noguchi S. , Itoh T. , Shigeta K. , Senba T. , Matsumura K. , Nakajima Y. , Mizuno T. , Morinaga M. , Sasaki M. , Togashi T. , Oyama M. , Hata H. , Watanabe M. , Komatsu T. , Mizushima-Sugano J. , Satoh T. , Shirai Y. , Takahashi Y. , Nakagawa K. , Okumura K. , Nagase T. , Nomura N. , Kikuchi H. , Masuho Y. , Yamashita R. , Nakai K. , Yada T. , Nakamura Y. , Ohara O. , Isogai T. , Sugano S. more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , Bailey J. , Banerjee R. , Barker D.J. , Barlow K.F. , Bates K. , Beasley H. , Beasley O. , Bird C.P. , Bray-Allen S. , Brown A.J. , Brown J.Y. , Burford D. , Burrill W. , Burton J. , Carder C. , Carter N.P. , Chapman J.C. , Chen Y. , Clarke G. , Clark S.Y. , Clee C.M. , Clegg S. , Collier R.E. , Corby N. , Crosier M. , Cummings A.T. , Davies J. , Dhami P. , Dunn M. , Dutta I. , Dyer L.W. , Earthrowl M.E. , Faulkner L. , Fleming C.J. , Frankish A. , Frankland J.A. , French L. , Fricker D.G. , Garner P. , Garnett J. , Ghori J. , Gilbert J.G.R. , Glison C. , Grafham D.V. , Gribble S. , Griffiths C. , Griffiths-Jones S. , Grocock R. , Guy J. , Hall R.E. , Hammond S. , Harley J.L. , Harrison E.S.I. , Hart E.A. , Heath P.D. , Henderson C.D. , Hopkins B.L. , Howard P.J. , Howden P.J. , Huckle E. , Johnson C. , Johnson D. , Joy A.A. , Kay M. , Keenan S. , Kershaw J.K. , Kimberley A.M. , King A. , Knights A. , Laird G.K. , Langford C. , Lawlor S. , Leongamornlert D.A. , Leversha M. , Lloyd C. , Lloyd D.M. , Lovell J. , Martin S. , Mashreghi-Mohammadi M. , Matthews L. , McLaren S. , McLay K.E. , McMurray A. , Milne S. , Nickerson T. , Nisbett J. , Nordsiek G. , Pearce A.V. , Peck A.I. , Porter K.M. , Pandian R. , Pelan S. , Phillimore B. , Povey S. , Ramsey Y. , Rand V. , Scharfe M. , Sehra H.K. , Shownkeen R. , Sims S.K. , Skuce C.D. , Smith M. , Steward C.A. , Swarbreck D. , Sycamore N. , Tester J. , Thorpe A. , Tracey A. , Tromans A. , Thomas D.W. , Wall M. , Wallis J.M. , West A.P. , Whitehead S.L. , Willey D.L. , Williams S.A. , Wilming L. , Wray P.W. , Young L. , Ashurst J.L. , Coulson A. , Blocker H. , Durbin R.M. , Sulston J.E. , Hubbard T. , Jackson M.J. , Bentley D.R. , Beck S. , Rogers J. , Dunham I. more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , Yooseph S. , Lu F. , Nusskern D.R. , Shue B.C. , Zheng X.H. , Zhong F. , Delcher A.L. , Huson D.H. , Kravitz S.A. , Mouchard L. , Reinert K. , Remington K.A. , Clark A.G. , Waterman M.S. , Eichler E.E. , Adams M.D. , Hunkapiller M.W. , Myers E.W. , Venter J.C. more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis."
Maisonpierre P.C. , Suri C. , Jones P.F. , Bartunkova S. , Wiegand S.J. , Radziejewski C. , Compton D.L. , McClain J. , Aldrich T.H. , Papadopoulos N. , Daly T.J. , Davis S. , Sato T.N. , Yancopoulos G.D.
Science277:55-60(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of a soluble form of the angiopoietin receptor TIE-2 released from endothelial cells and present in human blood."
Reusch P. , Barleon B. , Weindel K. , Martiny-Baron G. , Godde A. , Siemeister G. , Marme D.
Angiogenesis4:123-131(2001) [PubMed] [Europe PMC] [Abstract]

"Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2."
Murray B.W. , Padrique E.S. , Pinko C. , McTigue M.A.
Biochemistry40:10243-10253(2001) [PubMed] [Europe PMC] [Abstract]

"Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1."
Cascone I. , Audero E. , Giraudo E. , Napione L. , Maniero F. , Philips M.R. , Collard J.G. , Serini G. , Bussolino F.
Blood102:2482-2490(2003) [PubMed] [Europe PMC] [Abstract]

"The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2."
Hughes D.P. , Marron M.B. , Brindle N.P.
Circ. Res.92:630-636(2003) [PubMed] [Europe PMC] [Abstract]

"Biological characterization of angiopoietin-3 and angiopoietin-4."
Lee H.J. , Cho C.H. , Hwang S.J. , Choi H.H. , Kim K.T. , Ahn S.Y. , Kim J.H. , Oh J.L. , Lee G.M. , Koh G.Y.
FASEB J.18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]

"Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells."
Audero E. , Cascone I. , Maniero F. , Napione L. , Arese M. , Lanfrancone L. , Bussolino F.
J. Biol. Chem.279:13224-13233(2004) [PubMed] [Europe PMC] [Abstract]

"Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2."
Saharinen P. , Kerkela K. , Ekman N. , Marron M. , Brindle N. , Lee G.M. , Augustin H. , Koh G.Y. , Alitalo K.
J. Cell Biol.169:239-243(2005) [PubMed] [Europe PMC] [Abstract]

"Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1."
Fukuhara S. , Sako K. , Minami T. , Noda K. , Kim H.Z. , Kodama T. , Shibuya M. , Takakura N. , Koh G.Y. , Mochizuki N.
Nat. Cell Biol.10:513-526(2008) [PubMed] [Europe PMC] [Abstract]

"Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts."
Saharinen P. , Eklund L. , Miettinen J. , Wirkkala R. , Anisimov A. , Winderlich M. , Nottebaum A. , Vestweber D. , Deutsch U. , Koh G.Y. , Olsen B.R. , Alitalo K.
Nat. Cell Biol.10:527-537(2008) [PubMed] [Europe PMC] [Abstract]

"Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells."
Yacyshyn O.K. , Lai P.F.H. , Forse K. , Teichert-Kuliszewska K. , Jurasz P. , Stewart D.J.
Angiogenesis12:25-33(2009) [PubMed] [Europe PMC] [Abstract]

"Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation."
Wehrle C. , Van Slyke P. , Dumont D.J.
Biochem. J.423:375-380(2009) [PubMed] [Europe PMC] [Abstract]

"VE-PTP controls blood vessel development by balancing Tie-2 activity."
Winderlich M. , Keller L. , Cagna G. , Broermann A. , Kamenyeva O. , Kiefer F. , Deutsch U. , Nottebaum A.F. , Vestweber D.
J. Cell Biol.185:657-671(2009) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium."
Yuan H.T. , Khankin E.V. , Karumanchi S.A. , Parikh S.M.
Mol. Cell. Biol.29:2011-2022(2009) [PubMed] [Europe PMC] [Abstract]

"Tie2: a journey from normal angiogenesis to cancer and beyond."
Martin V. , Liu D. , Fueyo J. , Gomez-Manzano C.
Histol. Histopathol.23:773-780(2008) [PubMed] [Europe PMC] [Abstract]

"Tie2 is tied at the cell-cell contacts and to extracellular matrix by angiopoietin-1."
Fukuhara S. , Sako K. , Noda K. , Nagao K. , Miura K. , Mochizuki N.
Exp. Mol. Med.41:133-139(2009) [PubMed] [Europe PMC] [Abstract]

"Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system."
Augustin H.G. , Koh G.Y. , Thurston G. , Alitalo K.
Nat. Rev. Mol. Cell Biol.10:165-177(2009) [PubMed] [Europe PMC] [Abstract]

"Angiopoietin-1/Tie2 receptor signaling in vascular quiescence and angiogenesis."
Fukuhara S. , Sako K. , Noda K. , Zhang J. , Minami M. , Mochizuki N.
Histol. Histopathol.25:387-396(2010) [PubMed] [Europe PMC] [Abstract]

"Targeting the ANGPT-TIE2 pathway in malignancy."
Huang H. , Bhat A. , Woodnutt G. , Lappe R.
Nat. Rev. Cancer10:575-585(2010) [PubMed] [Europe PMC] [Abstract]

"Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail."
Shewchuk L.M. , Hassell A.M. , Ellis B. , Holmes W.D. , Davis R. , Horne E.L. , Kadwell S.H. , McKee D.D. , Moore J.T.
Structure8:1105-1113(2000) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex."
Barton W.A. , Tzvetkova-Robev D. , Miranda E.P. , Kolev M.V. , Rajashankar K.R. , Himanen J.P. , Nikolov D.B.
Nat. Struct. Mol. Biol.13:524-532(2006) [PubMed] [Europe PMC] [Abstract]

"Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors."
Hodous B.L. , Geuns-Meyer S.D. , Hughes P.E. , Albrecht B.K. , Bellon S. , Caenepeel S. , Cee V.J. , Chaffee S.C. , Emery M. , Fretland J. , Gallant P. , Gu Y. , Johnson R.E. , Kim J.L. , Long A.M. , Morrison M. , Olivieri P.R. , Patel V.F. , Polverino A. , Rose P. , Wang L. , Zhao H. more...
Bioorg. Med. Chem. Lett.17:2886-2889(2007) [PubMed] [Europe PMC] [Abstract]

"Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor."
Hodous B.L. , Geuns-Meyer S.D. , Hughes P.E. , Albrecht B.K. , Bellon S. , Bready J. , Caenepeel S. , Cee V.J. , Chaffee S.C. , Coxon A. , Emery M. , Fretland J. , Gallant P. , Gu Y. , Hoffman D. , Johnson R.E. , Kendall R. , Kim J.L. , Long A.M. , Morrison M. , Olivieri P.R. , Patel V.F. , Polverino A. , Rose P. , Tempest P. , Wang L. , Whittington D.A. , Zhao H. more...
J. Med. Chem.50:611-626(2007) [PubMed] [Europe PMC] [Abstract]

"Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo."
Luke R.W. , Ballard P. , Buttar D. , Campbell L. , Curwen J. , Emery S.C. , Griffen A.M. , Hassall L. , Hayter B.R. , Jones C.D. , McCoull W. , Mellor M. , Swain M.L. , Tucker J.A.
Bioorg. Med. Chem. Lett.19:6670-6674(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207."
Fedorov A.A. , Fedorov E.V. , Pauletti D. , Meyer S.L. , Hudkins R.L. , Almo S.C.
Submitted (2010-01) to the PDB data bank

"Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2."
Vikkula M. , Boon L.M. , Carraway K.L. III , Calvert J.T. , Diamonti A.J. , Goumnerov B. , Pasyk K.A. , Marchuk D.A. , Warman M.L. , Cantley L.C. , Mulliken J.B. , Olse B.R.
Cell87:1181-1190(1996) [PubMed] [Europe PMC] [Abstract]

"Allelic and locus heterogeneity in inherited venous malformations."
Calvert J.T. , Riney T.J. , Kontos C.D. , Cha E.H. , Prieto V.G. , Shea C.R. , Berg J.N. , Nevin N.C. , Simpson S.A. , Pasyk K.A. , Speer M.C. , Peters K.G. , Marchuk D.A.
Hum. Mol. Genet.8:1279-1289(1999) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , Gazdar A.F. , Hartigan J. , Wu L. , Liu C. , Parmigiani G. , Park B.H. , Bachman K.E. , Papadopoulos N. , Vogelstein B. , Kinzler K.W. , Velculescu V.E. more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , Choudhury B. , Clements J. , Cole J. , Dicks E. , Forbes S. , Gray K. , Halliday K. , Harrison R. , Hills K. , Hinton J. , Jenkinson A. , Jones D. , Menzies A. , Mironenko T. , Perry J. , Raine K. , Richardson D. , Shepherd R. , Small A. , Tofts C. , Varian J. , Webb T. , West S. , Widaa S. , Yates A. , Cahill D.P. , Louis D.N. , Goldstraw P. , Nicholson A.G. , Brasseur F. , Looijenga L. , Weber B.L. , Chiew Y.-E. , DeFazio A. , Greaves M.F. , Green A.R. , Campbell P. , Birney E. , Easton D.F. , Chenevix-Trench G. , Tan M.-H. , Khoo S.K. , Teh B.T. , Yuen S.T. , Leung S.Y. , Wooster R. , Futreal P.A. , Stratton M.R. more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

"Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects."
Wouters V. , Limaye N. , Uebelhoer M. , Irrthum A. , Boon L.M. , Mulliken J.B. , Enjolras O. , Baselga E. , Berg J. , Dompmartin A. , Ivarsson S.A. , Kangesu L. , Lacassie Y. , Murphy J. , Teebi A.S. , Penington A. , Rieu P. , Vikkula M.
Eur. J. Hum. Genet.18:414-420(2010) [PubMed] [Europe PMC] [Abstract]