Tek ELISA Kit for Mouse(Mus musculus) | EIAab.comTek ELISA Kit for Mouse(Mus musculus)

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Tek (Gene name),

Angiopoietin-1 receptor (Protein name ), TIE2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Tek(Hyk;Tie-2;Tie2);

Protein name:

Angiopoietin-1 receptor;

Alternative:

STK1;HYK;Tyrosine-protein kinase receptor TEK;Tunica interna endothelial cell kinase;p140 TEK;Tyrosine-protein kinase receptor TIE-2(mTIE2);p140 TEK;Tyrosine-protein kinase receptor TIE-2(mTIE2);

CD:

CD202b;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with PTPRB.

Function:

This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1122

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1122:

VNTTLYEKFT | YAGIDCSAEE | AA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q02858

SMR:

Q02858

Pfam:

PF00041

UniGene:

Mm.14313

Uniprot:

Q02858

FOR

ELISA Kit for Mouse Angiopoietin-1 receptor

Cat.:

E0126h

Price:

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Manual:

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Packing:

96T

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ELISA Kit for Mouse Angiopoietin-1 receptor

Cat.:

E0126m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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ELISA Kit for Mouse Angiopoietin-1 receptor

Cat.:

E0126b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Angiopoietin-1 receptor

Cat.:

U0126m

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Mouse Angiopoietin-1 receptor

Cat.:

U0126h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Mouse Angiopoietin-1 receptor

Cat.:

U0126b

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Angiopoietin-1 receptor

Cat.:

P0126Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Angiopoietin-1 receptor

Cat.:

P0126Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Angiopoietin-1 receptor

Protein for Mouse Angiopoietin-1 receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system."
Sato T.N. , Qin Y. , Kozak C.A. , Andus K.L.
Proc. Natl. Acad. Sci. U.S.A.90:9355-9358(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
tissue: Lung.
2.

"The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors."
Dumont D.J. , Gradwol G.J. , Fong G.-H. , Auerbach R. , Breitman M.L.
Oncogene8:1293-1301(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: CD-1.
tissue: Embryonic heart.
3.

"A novel tyrosine kinase, hyk, expressed in murine embryonic stem cells."
Horita K. , Yagi T. , Kohmura N. , Tomooka Y. , Ikawa Y. , Aizawa S.
Biochem. Biophys. Res. Commun.189:1747-1753(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Embryonic stem cell.
4.

"Tie2, a putative protein tyrosine kinase from a new class of cell surface receptor."
Runting A.S. , Stacker S.A. , Wilks A.F.
Growth Factors9:99-105(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Lung.
5.

"Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage."
Schnuerch H. , Risau W.
Development119:957-968(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells."
Iwama A. , Hamaguchi I. , Hashiyama M. , Murayama Y. , Yasunaga K. , Suda T.
Biochem. Biophys. Res. Commun.195:301-309(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Hematopoietic stem cell.
7.

"Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors."
Dumont D.J. , Yamaguchi T.P. , Conlon R.A. , Rossant J. , Breitman M.L.
Oncogene7:1471-1480(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 822-1122
strain: CD-1.
tissue: Embryonic heart.
8.

"Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo."
Dumont D.J. , Gradwohl G. , Fong G.H. , Puri M.C. , Gertsenstein M. , Auerbach A. , Breitman M.L.
Genes Dev.8:1897-1909(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;MUTAGENESIS OF LYS-853;CATALYTIC ACTIVITY;FUNCTION
9.

"Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation."
Sato T.N. , Tozawa Y. , Deutsch U. , Wolburg-Buchholz K. , Fujiwara Y. , Gendron-Maguire M. , Gridley T. , Wolburg H. , Risau W. , Qin Y.
Nature376:70-74(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
10.

"Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt."
Kontos C.D. , Stauffer T.P. , Yang W.P. , York J.D. , Huang L. , Blanar M.A. , Meyer T. , Peters K.G.
Mol. Cell. Biol.18:4131-4140(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1;MUTAGENESIS OF TYR-1100;FUNCTION IN ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE AND AKT1
11.

"Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration."
Jones N. , Master Z. , Jones J. , Bouchard D. , Gunji Y. , Sasaki H. , Daly R. , Alitalo K. , Dumont D.J.
J. Biol. Chem.274:30896-30905(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2; GRB7;GRB14;PTPN11/SHP2 AND PIK3R1;FUNCTION IN PHOSPHORYLATION OF GRB7 AND PIK3R1;MUTAGENESIS OF TYR-1100
12.

"Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2."
Fachinger G. , Deutsch U. , Risau W.
Oncogene18:5948-5953(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPRB
13.

"Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function."
Jones N. , Voskas D. , Master Z. , Sarao R. , Jones J. , Dumont D.J.
EMBO Rep.2:438-445(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ANTI-APOPTOTIC FUNCTION
14.

"Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats."
Fiedler U. , Krissl T. , Koidl S. , Weiss C. , Koblizek T. , Deutsch U. , Martiny-Baron G. , Marme D. , Augustin H.G.
J. Biol. Chem.278:1721-1727(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ANGPT1 AND ANGPT2;DOMAIN
15.

"A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function."
Jones N. , Chen S.H. , Sturk C. , Master Z. , Tran J. , Kerbel R.S. , Dumont D.J.
Mol. Cell. Biol.23:2658-2668(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-1100 AND TYR-1106;MUTAGENESIS OF LYS-853; TYR-1100 AND TYR-1106;FUNCTION IN DOK2 PHOSPHORYLATION;INTERACTION WITH DOK2
16.

"Biological characterization of angiopoietin-3 and angiopoietin-4."
Lee H.J. , Cho C.H. , Hwang S.J. , Choi H.H. , Kim K.T. , Ahn S.Y. , Kim J.H. , Oh J.L. , Lee G.M. , Koh G.Y.
FASEB J.18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS ANGPT4 RECEPTOR AND IN ACTIVATION OF AKT1;INTERACTION WITH ANGPT4;AUTOPHOSPHORYLATION
17.

"VE-PTP controls blood vessel development by balancing Tie-2 activity."
Winderlich M. , Keller L. , Cagna G. , Broermann A. , Kamenyeva O. , Kiefer F. , Deutsch U. , Nottebaum A.F. , Vestweber D.
J. Cell Biol.185:657-671(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRB
18.

"Tyrosine phosphorylation of Grb14 by Tie2."
Sturk C. , Dumont D.J.
Cell Commun. Signal.8:30-30(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB14;FUNCTION IN GRB14 PHOSPHORYLATION

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