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Index > Protein center > Timp2(Gene name) > Rat
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  • Timp2 (Gene name),
  • Metalloproteinase inhibitor 2 (Protein name ),  TIMP2_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Timp2(Timp-2);
    Protein name:
    Metalloproteinase inhibitor 2;
    Alternative:
    Tissue inhibitor of metalloproteinases 2(TIMP-2);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.
    Function:
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    220
    Sequence:
    50:
    MGAAARSLRL | ALGLLLLATL | LRPADACSCS | PVHPQQAFCN | ADVVIRAKAV | 
    100:
    SEKEVDSGND | IYGNPIKRIQ | YEIKQIKMFK | GPDKDIEFIY | TAPSSAVCGV | 
    150:
    SLDVGGKKEY | LIAGKAEGDG | KMHITLCDFI | VPWDTLSITQ | KKSLNHRYQM | 
    200:
    GCECKITRCP | MIPCYISSPD | ECLWMDWVTE | KSINGHQAKF | FACIKRSDGS | 
    220:
    CAWYRGAAPP | KQEFLDIEDP | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Metalloproteinase inhibitor 2
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    E0128h
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    96T
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    ELISA Kit for Rat Metalloproteinase inhibitor 2
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    E0128r
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    96T
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    ELISA Kit for Rat Metalloproteinase inhibitor 2
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    E0128m
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    96T
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    ELISA Kit for Rat Metalloproteinase inhibitor 2
    Cat.:
    E0128c
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    96T
    ELISA Kit for Rat Metalloproteinase inhibitor 2
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    E0128d
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    96T
    ELISA Kit for Rat Metalloproteinase inhibitor 2
    Cat.:
    E0128b
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    96T
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    ELISA Kit for Rat Metalloproteinase inhibitor 2
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Metalloproteinase inhibitor 2
    MSDS:
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    CLIA Kit for Rat Metalloproteinase inhibitor 2
    Cat.:
    U0128b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Metalloproteinase inhibitor 2
    Cat.:
    U0128h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Metalloproteinase inhibitor 2
    Cat.:
    U0128m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Metalloproteinase inhibitor 2
    Cat.:
    U0128r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Metalloproteinase inhibitor 2
    Cat.:
    U0128d
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Metalloproteinase inhibitor 2
    Cat.:
    U0128c
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Rat Metalloproteinase inhibitor 2
    Polyclonal Antibody for Rat Metalloproteinase inhibitor 2
    Polyclonal Antibody for Rat Metalloproteinase inhibitor 2
    Polyclonal Antibody for Rat Metalloproteinase inhibitor 2
    Polyclonal Antibody for Rat Metalloproteinase inhibitor 2
    Cat.:
    P0128Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Metalloproteinase inhibitor 2
    Cat.:
    P0128Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Metalloproteinase inhibitor 2
    Cat.:
    P0128Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Metalloproteinase inhibitor 2
    Monoclonal Antibody for Rat Metalloproteinase inhibitor 2
    Monoclonal Antibody for Rat Metalloproteinase inhibitor 2
    Monoclonal Antibody for Rat Metalloproteinase inhibitor 2
    Monoclonal Antibody for Rat Metalloproteinase inhibitor 2
    Monoclonal Antibody for Rat Metalloproteinase inhibitor 2
    Monoclonal Antibody for Rat Metalloproteinase inhibitor 2
    Protein for Rat Metalloproteinase inhibitor 2
    Protein for Rat Metalloproteinase inhibitor 2
    Protein for Rat Metalloproteinase inhibitor 2
    Protein for Rat Metalloproteinase inhibitor 2
    Protein for Rat Metalloproteinase inhibitor 2
    Protein for Rat Metalloproteinase inhibitor 2
    Protein for Rat Metalloproteinase inhibitor 2
    Cat.:
    R0128h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

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    References
    1. 1.
      "Cloning and regulation of rat tissue inhibitor of metalloproteinases-2 in osteoblastic cells."
      Cook T.F. , Burke J.S. , Bergman K.D. , Quinn C.O. , Jeffrey J.J. , Partridge N.C.
      Arch. Biochem. Biophys.311:313-320(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Bone.
    2. 2.
      Gibbons K.L. , O'Grady R.L. , Piper A.A.
      Submitted (1995-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Mammary gland.
    3. 3.
      "Cloning of the rat tissue inhibitor of metalloproteinases type 2 (TIMP-2) gene: analysis of its expression in normal and transformed thyroid cells."
      Santoro M. , Battaglia C. , Zhang L. , Carlomagno F. , Martelli M.L. , Salvatore D. , Fusco A.
      Exp. Cell Res.213:398-403(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Purification, cDNA cloning, and developmental changes in the steady-state mRNA level of rat testicular tissue inhibitor of metalloproteases-2 (TIMP-2)."
      Grima J. , Calcagno K. , Cheng C.Y.
      J. Androl.17:263-275(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Testis.
    5. 5.
      "Cardiac remodeling after long term norepinephrine treatment in rats."
      Briest W. , Hoelzl A. , Rassler B. , Deten A. , Leicht M. , Baba H.A. , Zimmer H.G.
      Cardiovasc. Res.52:265-273(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Heart.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Ovary.
    7. 7.
      "Purification and sequence analysis of two rat tissue inhibitors of metalloproteinases."
      Roswit W.T. , McCourt D.W. , Partridge N.C. , Jeffrey J.J.
      Arch. Biochem. Biophys.292:402-410(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-48
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