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Index > Protein center > TLN2(Gene name) > Human
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  • TLN2 (Gene name),
  • Talin-2 (Protein name ),  TLN2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TLN2(KIAA0320);
    Protein name:
    Talin-2;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts directly with PIP5K1C.
    Function:
    As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity.
    Subcellular Location:
    Cell junction focal adhesion Cell junction synapse Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton Focal adhesion plaques and synapses.
    Protein Attributes:
    Sequence length:
    2542
    Sequence:
    50:
    MVALSLKICV | RHCNVVKTMQ | FEPSTAVYDA | CRVIRERVPE | AQTGQASDYG | 
    100:
    LFLSDEDPRK | GIWLEAGRTL | DYYMLRNGDI | LEYKKKQRPQ | KIRMLDGSVK | 
    150:
    TVMVDDSKTV | GELLVTICSR | IGITNYEEYS | LIQETIEEKK | EEGTGTLKKD | 
    200:
    RTLLRDERKM | EKLKAKLHTD | DDLNWLDHSR | TFREQGVDEN | ETLLLRRKFF | 
    250:
    YSDQNVDSRD | PVQLNLLYVQ | ARDDILNGSH | PVSFEKACEF | GGFQAQIQFG | 
    300:
    PHVEHKHKPG | FLDLKEFLPK | EYIKQRGAEK | RIFQEHKNCG | EMSEIEAKVK | 
    350:
    YVKLARSLRT | YGVSFFLVKE | KMKGKNKLVP | RLLGITKDSV | MRVDEKTKEV | 
    400:
    LQEWPLTTVK | RWAASPKSFT | LDFGEYQESY | YSVQTTEGEQ | ISQLIAGYID | 
    450:
    IILKKKQSKD | RFGLEGDEES | TMLEESVSPK | KSTILQQQFN | RTGKAEHGSV | 
    500:
    ALPAVMRSGS | SGPETFNVGS | MPSPQQQVMV | GQMHRGHMPP | LTSAQQALMG | 
    550:
    TINTSMHAVQ | QAQDDLSELD | SLPPLGQDMA | SRVWVQNKVD | ESKHEIHSQV | 
    600:
    DAITAGTASV | VNLTAGDPAD | TDYTAVGCAI | TTISSNLTEM | SKGVKLLAAL | 
    650:
    MDDEVGSGED | LLRAARTLAG | AVSDLLKAVQ | PTSGEPRQTV | LTAAGSIGQA | 
    700:
    SGDLLRQIGE | NETDERFQDV | LMSLAKAVAN | AAAMLVLKAK | NVAQVAEDTV | 
    750:
    LQNRVIAAAT | QCALSTSQLV | ACAKVVSPTI | SSPVCQEQLI | EAGKLVDRSV | 
    800:
    ENCVRACQAA | TTDSELLKQV | SAAASVVSQA | LHDLLQHVRQ | FASRGEPIGR | 
    850:
    YDQATDTIMC | VTESIFSSMG | DAGEMVRQAR | VLAQATSDLV | NAMRSDAEAE | 
    900:
    IDMENSKKLL | AAAKLLADST | ARMVEAAKGA | AANPENEDQQ | QRLREAAEGL | 
    950:
    RVATNAAAQN | AIKKKIVNRL | EVAAKQAAAA | ATQTIAASQN | AAVSNKNPAA | 
    1000:
    QQQLVQSCKA | VADHIPQLVQ | GVRGSQAQAE | DLSAQLALII | SSQNFLQPGS | 
    1050:
    KMVSSAKAAV | PTVSDQAAAM | QLSQCAKNLA | TSLAELRTAS | QKAHEACGPM | 
    1100:
    EIDSALNTVQ | TLKNELQDAK | MAAVESQLKP | LPGETLEKCA | QDLGSTSKAV | 
    1150:
    GSSMAQLLTC | AAQGNEHYTG | VAARETAQAL | KTLAQAARGV | AASTTDPAAA | 
    1200:
    HAMLDSARDV | MEGSAMLIQE | AKQALIAPGD | AERQQRLAQV | AKAVSHSLNN | 
    1250:
    CVNCLPGQKD | VDVALKSIGE | SSKKLLVDSL | PPSTKPFQEA | QSELNQAAAD | 
    1300:
    LNQSAGEVVH | ATRGQSGELA | AASGKFSDDF | DEFLDAGIEM | AGQAQTKEDQ | 
    1350:
    IQVIGNLKNI | SMASSKLLLA | AKSLSVDPGA | PNAKNLLAAA | ARAVTESINQ | 
    1400:
    LITLCTQQAP | GQKECDNALR | ELETVKGMLD | NPNEPVSDLS | YFDCIESVME | 
    1450:
    NSKVLGESMA | GISQNAKTGD | LPAFGECVGI | ASKALCGLTE | AAAQAAYLVG | 
    1500:
    ISDPNSQAGH | QGLVDPIQFA | RANQAIQMAC | QNLVDPGSSP | SQVLSAATIV | 
    1550:
    AKHTSALCNA | CRIASSKTAN | PVAKRHFVQS | AKEVANSTAN | LVKTIKALDG | 
    1600:
    DFSEDNRNKC | RIATAPLIEA | VENLTAFASN | PEFVSIPAQI | SSEGSQAQEP | 
    1650:
    ILVSAKTMLE | SSSYLIRTAR | SLAINPKDPP | TWSVLAGHSH | TVSDSIKSLI | 
    1700:
    TSIRDKAPGQ | RECDYSIDGI | NRCIRDIEQA | SLAAVSQSLA | TRDDISVEAL | 
    1750:
    QEQLTSVVQE | IGHLIDPIAT | AARGEAAQLG | HKVTQLASYF | EPLILAAVGV | 
    1800:
    ASKILDHQQQ | MTVLDQTKTL | AESALQMLYA | AKEGGGNPKA | QHTHDAITEA | 
    1850:
    AQLMKEAVDD | IMVTLNEAAS | EVGLVGGMVD | AIAEAMSKLD | EGTPPEPKGT | 
    1900:
    FVDYQTTVVK | YSKAIAVTAQ | EMMTKSVTNP | EELGGLASQM | TSDYGHLAFQ | 
    1950:
    GQMAAATAEP | EEIGFQIRTR | VQDLGHGCIF | LVQKAGALQV | CPTDSYTKRE | 
    2000:
    LIECARAVTE | KVSLVLSALQ | AGNKGTQACI | TAATAVSGII | ADLDTTIMFA | 
    2050:
    TAGTLNAENS | ETFADHRENI | LKTAKALVED | TKLLVSGAAS | TPDKLAQAAQ | 
    2100:
    SSAATITQLA | EVVKLGAASL | GSDDPETQVV | LINAIKDVAK | ALSDLISATK | 
    2150:
    GAASKPVDDP | SMYQLKGAAK | VMVTNVTSLL | KTVKAVEDEA | TRGTRALEAT | 
    2200:
    IECIKQELTV | FQSKDVPEKT | SSPEESIRMT | KGITMATAKA | VAAGNSCRQE | 
    2250:
    DVIATANLSR | KAVSDMLTAC | KQASFHPDVS | DEVRTRALRF | GTECTLGYLD | 
    2300:
    LLEHVLVILQ | KPTPEFKQQL | AAFSKRVAGA | VTELIQAAEA | MKGTEWVDPE | 
    2350:
    DPTVIAETEL | LGAAASIEAA | AKKLEQLKPR | AKPKQADETL | DFEEQILEAA | 
    2400:
    KSIAAATSAL | VKSASAAQRE | LVAQGKVGSI | PANAADDGQW | SQGLISAARM | 
    2450:
    VAAATSSLCE | AANASVQGHA | SEEKLISSAK | QVAASTAQLL | VACKVKADQD | 
    2500:
    SEAMRRLQAA | GNAVKRASDN | LVRAAQKAAF | GKADDDDVVV | KTKFVGGIAQ | 
    2542:
    IIAAQEEMLK | KERELEEARK | KLAQIRQQQY | KFLPTELRED | EG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Talin-2
    Cat.:
    E1961h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Talin-2
    Cat.:
    E1961m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Talin-2
    Cat.:
    U1961m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Talin-2
    Cat.:
    U1961h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Talin-2
    Cat.:
    P1961Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Talin-2
    Cat.:
    P1961Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Talin-2
    Monoclonal Antibody for Human Talin-2
    Protein for Human Talin-2
    Protein for Human Talin-2

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    Precision
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    Recovery
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    Linearity
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    Citations
    [1].
    Zheng Xiao1, Lan Shen1, Dan Chen, Liang Wang, Zhiqin Xi, Fei Xiao, Xuefeng Wang
    References
    1. 1.
      "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin."
      Di Paolo G. , Pellegrini L. , Letinic K. , Cestra G. , Zoncu R. , Voronov S. , Chang S. , Guo J. , Wenk M.R. , De Camilli P.
      Nature420:85-89(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
      tissue: Skeletal muscle.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 4.
      "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Nakajima D. , Ohira M. , Seki N. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 610-2542
      tissue: Brain.
    4. 5.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    5. 6.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1843;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 8.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 10.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1843;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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