TLR1 ELISA Kit for Human(Homo sapiens) | EIAab.comTLR1 ELISA Kit for Human(Homo sapiens)

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TLR1 (Gene name),

Toll-like receptor 1 (Protein name ), TLR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TLR1(KIAA0012);

Protein name:

Toll-like receptor 1;

Alternative:

Toll/interleukin-1 receptor-like protein(TIL);

CD:

CD281;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.

Function:

Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Cytoplasmic vesicle phagosome membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

786

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

786:

ARRTYLEWPK | EKSKRGLFWA | NLRAAINIKL | TEQAKK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

601194

UniGene:

Hs.621817

KEGG:

hsa:7096

STRING:

9606.ENSP00000354932

String:

Q15399

Pfam:

PF01582

Pfam:

PF00560

SMR:

Q15399

Uniprot:

Q15399

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ELISA Kit for Human Toll-like receptor 1

Cat.:

E1988m

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Manual:

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Packing:

96T

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ELISA Kit for Human Toll-like receptor 1

Cat.:

E1988h

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Packing:

96T

CLIA Kit for Human Toll-like receptor 1

Cat.:

U1988h

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Packing:

96T

CLIA Kit for Human Toll-like receptor 1

Cat.:

U1988m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Toll-like receptor 1

Cat.:

P1988Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Toll-like receptor 1

Cat.:

P1988Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Toll-like receptor 1

Protein for Human Toll-like receptor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"A family of human receptors structurally related to Drosophila Toll."
Rock F.L. , Hardiman G. , Timans J.C. , Kastelein R.A. , Bazan J.F.
Proc. Natl. Acad. Sci. U.S.A.95:588-593(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS SER-248 AND ILE-602
tissue: Erythroleukemia.
2.

"Natural selection in the TLR-related genes in the course of primate evolution."
Nakajima T. , Ohtani H. , Satta Y. , Uno Y. , Akari H. , Ishida T. , Kimura A.
Immunogenetics60:727-735(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
Georgel P. , Macquin C. , Bahram S.
PLoS ONE4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS THR-80 AND ILE-602
4.

"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
Nomura N. , Miyajima N. , Sazuka T. , Tanaka A. , Kawarabayasi Y. , Sato S. , Nagase T. , Seki N. , Ishikawa K. , Tabata S.
DNA Res.1:27-35(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT THR-80
tissue: Bone marrow.
5.

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S. , Weil B. , Wellenreuther R. , Gassenhuber J. , Glassl S. , Ansorge W. , Boecher M. , Bloecker H. , Bauersachs S. , Blum H. , Lauber J. , Duesterhoeft A. , Beyer A. , Koehrer K. , Strack N. , Mewes H.-W. , Ottenwaelder B. , Obermaier B. , more...
Genome Res.11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS SER-248 AND ILE-602
tissue: Brain.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS SER-248 AND ILE-602
7.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-39
8.

"Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy."
Johnson C.M. , Lyle E.A. , Omueti K.O. , Stepensky V.A. , Yegin O. , Alpsoy E. , Hamann L. , Schumann R.R. , Tapping R.I.
J. Immunol.178:7520-7524(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PROTECTION AGAINST LEPROSY
9.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-163
tissue: Liver.
10.

"Structural basis for signal transduction by the Toll/interleukin-1 receptor domains."
Xu Y. , Tao X. , Shen B. , Horng T. , Medzhitov R. , Manley J.L. , Tong L.
Nature408:111-115(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 625-785
11.

"Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide."
Jin M.S. , Kim S.E. , Heo J.Y. , Lee M.E. , Kim H.M. , Paik S.-G. , Lee H. , Lee J.-O.
Cell130:1071-1082(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 25-476 IN COMPLEX WITH TLR1 AND BACTERIAL LIPOPEPTIDE ANALOG;DISULFIDE BONDS;GLYCOSYLATION AT ASN-51; ASN-163; ASN-330 AND ASN-429
12.

"Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions."
Schuring R.P. , Hamann L. , Faber W.R. , Pahan D. , Richardus J.H. , Schumann R.R. , Oskam L.
J. Infect. Dis.199:1816-1819(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT SER-248 WITH SUSCEPTIBILITY TO LEPROSY
13.

"Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."
Ben-Ali M. , Corre B. , Manry J. , Barreiro L.B. , Quach H. , Boniotto M. , Pellegrini S. , Quintana-Murci L.
Hum. Mutat.32:643-652(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-44; THR-75; THR-80; TYR-118; SER-248; LEU-305; LEU-315; ASN-352; VAL-460; ALA-542; CYS-554; GLY-587; ILE-602; ALA-651; ALA-674; PRO-720 AND LEU-733;CHARACTERIZATION OF VARIANTS LEU-315; CYS-554; ILE-602; ALA-651 AND PRO-720

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