Protein name:
Toll-like receptor 2 ;
Alternative:
CD:
CD282 ;
Organism:
Dog (Canis familiarisCanis lupus familiaris).
General Annotation
Sub Unit:
Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 (By similarity). Interacts with CNPY3.
Function:
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MSRVLWTLWV | LGAVTNLSKE | EAPDQSSSLS | CDPTGVCDGR | SRSLNSMPSG |
100:
LTAAVRSLDL | SNNEITYIGN | SDLRDCVNLK | ALRLESNGIN | TIEEESFLSL |
150:
WSLEHLDLSY | NLLSNLSSSW | FRPLSSLKFL | NLLGNPYKSL | GETPLFSQLT |
200:
NLRILKVGNI | YSFTEIQDKD | FAGLTFLEEL | EIDASNLQRY | EPKSLKSIQN |
250:
ISYLALRMKQ | PVLLVEIFVD | LSSSLKHLEL | RDTHLDTFHF | SEASINETHT |
300:
LVKKWTFRNV | KVTDRSFTGV | VRLLNYVSGV | LEVEFEDCTL | YGLGDFDIPD |
350:
VDKIKNIGQI | ETLTVRRLHI | PHFYSFYDMS | SIYSLTEDVK | RITVENSKVF |
400:
LVPCLLSQHL | KSLEYLDLSE | NLMVEEYLKN | SACEDAWPSL | QTLVLRQNHL |
450:
ASLERTGETL | LTLKNLTNID | ISKNSFHSMP | ETCQWPEKMK | YLNLSSTRIH |
500:
SVTGCIPKTL | EILDVSNNNL | NLFSLNLPQL | KELYISRNKL | MTLPDASLLP |
550:
MLLVLKISRN | AITTFSKEQL | DSFHTLKTLE | AGGNNFICSC | EFLSFTQEQQ |
600:
ALAKVLIDWP | ANYLCDSPSH | VRGQQVQDVR | LSVSECHRTA | LVSGMCCALF |
650:
LLILLTEVLC | HRFHGLWYMR | MMWAWLQAKR | KPRKAPSRDV | CYDAFVSYSE |
700:
HDSYWVENLL | VQKLEHFNPP | FKLCLHKRDF | IPGKWIIDNI | IDSIEKSRKT |
750:
IFVLSENFVK | SEWCKYELDF | SHFRLFDENS | DAAILILLEP | IEKKAIPQRF |
785:
CKLRKIMNTK | TYLEWPTDDA | QQEGFWLNLR | TAIKS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Dog
Bovine
ELISA Kit for Dog Toll-like receptor 2
ELISA Kit for Dog Toll-like receptor 2
ELISA Kit for Dog Toll-like receptor 2
ELISA Kit for Dog Toll-like receptor 2
CLIA Kit for Dog Toll-like receptor 2
CLIA Kit for Dog Toll-like receptor 2
CLIA Kit for Dog Toll-like receptor 2
CLIA Kit for Dog Toll-like receptor 2
Polyclonal Antibody for Dog Toll-like receptor 2
Polyclonal Antibody for Dog Toll-like receptor 2
Polyclonal Antibody for Dog Toll-like receptor 2
Polyclonal Antibody for Dog Toll-like receptor 2
Monoclonal Antibody for Dog Toll-like receptor 2
Monoclonal Antibody for Dog Toll-like receptor 2
Monoclonal Antibody for Dog Toll-like receptor 2
Monoclonal Antibody for Dog Toll-like receptor 2
Protein for Dog Toll-like receptor 2
Protein for Dog Toll-like receptor 2
Protein for Dog Toll-like receptor 2
Protein for Dog Toll-like receptor 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Bin Yang, Yifen Zhang, Liuhua Zhou, Zeyu Sun,Junhua Zheng, Yun Chen, and Yutian Dai,
References
1.
"Molecular cloning of canine Toll-like receptor 2 (TLR2) gene."
Ishii M.
,
Kano R.
,
Hasegawa A.
Submitted (2004-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]