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Index > Protein center > TLR3(Gene name) > Human
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  • TLR3 (Gene name),
  • Toll-like receptor 3 (Protein name ),  TLR3_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    TLR3;
    Protein name:
    Toll-like receptor 3;
    Alternative:

    CD:
    CD283;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MYD88 via their respective TIR domains. Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with TICAM1. Homodimer formation is triggered by ligand binding and is required for TLR3 signaling. Binding of double-stranded RNA is required for the interaction with SRC.
    Function:
    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type I membrane protein Endosome membrane
    Protein Attributes:
    Sequence length:
    904
    Sequence:
    50:
    MRQTLPCIYF | WGGLLPFGML | CASSTTKCTV | SHEVADCSHL | KLTQVPDDLP | 
    100:
    TNITVLNLTH | NQLRRLPAAN | FTRYSQLTSL | DVGFNTISKL | EPELCQKLPM | 
    150:
    LKVLNLQHNE | LSQLSDKTFA | FCTNLTELHL | MSNSIQKIKN | NPFVKQKNLI | 
    200:
    TLDLSHNGLS | STKLGTQVQL | ENLQELLLSN | NKIQALKSEE | LDIFANSSLK | 
    250:
    KLELSSNQIK | EFSPGCFHAI | GRLFGLFLNN | VQLGPSLTEK | LCLELANTSI | 
    300:
    RNLSLSNSQL | STTSNTTFLG | LKWTNLTMLD | LSYNNLNVVG | NDSFAWLPQL | 
    350:
    EYFFLEYNNI | QHLFSHSLHG | LFNVRYLNLK | RSFTKQSISL | ASLPKIDDFS | 
    400:
    FQWLKCLEHL | NMEDNDIPGI | KSNMFTGLIN | LKYLSLSNSF | TSLRTLTNET | 
    450:
    FVSLAHSPLH | ILNLTKNKIS | KIESDAFSWL | GHLEVLDLGL | NEIGQELTGQ | 
    500:
    EWRGLENIFE | IYLSYNKYLQ | LTRNSFALVP | SLQRLMLRRV | ALKNVDSSPS | 
    550:
    PFQPLRNLTI | LDLSNNNIAN | INDDMLEGLE | KLEILDLQHN | NLARLWKHAN | 
    600:
    PGGPIYFLKG | LSHLHILNLE | SNGFDEIPVE | VFKDLFELKI | IDLGLNNLNT | 
    650:
    LPASVFNNQV | SLKSLNLQKN | LITSVEKKVF | GPAFRNLTEL | DMRFNPFDCT | 
    700:
    CESIAWFVNW | INETHTNIPE | LSSHYLCNTP | PHYHGFPVRL | FDTSSCKDSA | 
    750:
    PFELFFMINT | SILLIFIFIV | LLIHFEGWRI | SFYWNVSVHR | VLGFKEIDRQ | 
    800:
    TEQFEYAAYI | IHAYKDKDWV | WEHFSSMEKE | DQSLKFCLEE | RDFEAGVFEL | 
    850:
    EAIVNSIKRS | RKIIFVITHH | LLKDPLCKRF | KVHHAVQQAI | EQNLDSIILV | 
    900:
    FLEEIPDYKL | NHALCLRRGM | FKSHCILNWP | VQKERIGAFR | HKLQVALGSK | 
    904:
    NSVH
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    String:
    UniGene:
    MIM:
    Pfam:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Toll-like receptor 3
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    E1989h
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    ELISA Kit for Human Toll-like receptor 3
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    E1989m
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    ELISA Kit for Human Toll-like receptor 3
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    E1989b
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    Packing:
    96T
    CLIA Kit for Human Toll-like receptor 3
    Cat.:
    U1989b
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    Packing:
    96T
    CLIA Kit for Human Toll-like receptor 3
    Cat.:
    U1989m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Toll-like receptor 3
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    U1989h
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    Packing:
    96T
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    Polyclonal Antibody for Human Toll-like receptor 3
    Polyclonal Antibody for Human Toll-like receptor 3
    Cat.:
    P1989Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Toll-like receptor 3
    Cat.:
    P1989Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Toll-like receptor 3
    Monoclonal Antibody for Human Toll-like receptor 3
    Monoclonal Antibody for Human Toll-like receptor 3
    Protein for Human Toll-like receptor 3
    Protein for Human Toll-like receptor 3
    Protein for Human Toll-like receptor 3

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    References
    1. 1.
      "A common polymorphism in TLR3 confers natural resistance to HIV-1 infection."
      Sironi M. , Biasin M. , Cagliani R. , Forni D. , De Luca M. , Saulle I. , Lo Caputo S. , Mazzotta F. , Macias J. , Pineda J.A. , Caruz A. , Clerici M.
      J. Immunol.188:818-823(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PHE-412
    2. 2.
      "A family of human receptors structurally related to Drosophila Toll."
      Rock F.L. , Hardiman G. , Timans J.C. , Kastelein R.A. , Bazan J.F.
      Proc. Natl. Acad. Sci. U.S.A.95:588-593(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA."
      Lafon M. , Megret F. , Lafage M. , Prehaud C.
      J. Mol. Neurosci.29:185-194(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Neuron.
    4. 4.
      "Natural selection in the TLR-related genes in the course of primate evolution."
      Nakajima T. , Ohtani H. , Satta Y. , Uno Y. , Akari H. , Ishida T. , Kimura A.
      Immunogenetics60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "TLR polymorphism."
      Macquin C. , Bahram S.
      Submitted (2006-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PHE-412
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT PHE-412
      tissue: Testis.
      tissue: Thymus.
    7. 7.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    10. 10.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-38
    11. 11.
      "A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling."
      Yamamoto M. , Sato S. , Mori K. , Hoshino K. , Takeuchi O. , Takeda K. , Akira S.
      J. Immunol.169:6668-6672(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TICAM1
    12. 12.
      "TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction."
      Oshiumi H. , Matsumoto M. , Funami K. , Akazawa T. , Seya T.
      Nat. Immunol.4:161-167(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TICAM1
      tissue: Lung.
    13. 13.
      "Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH."
      de Bouteiller O. , Merck E. , Hasan U.A. , Hubac S. , Benguigui B. , Trinchieri G. , Bates E.E. , Caux C.
      J. Biol. Chem.280:38133-38145(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;MUTAGENESIS OF CYS-95; CYS-122; ASN-196 AND ASN-247
    14. 14.
      "Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling."
      Johnsen I.B. , Nguyen T.T. , Ringdal M. , Tryggestad A.M. , Bakke O. , Lien E. , Espevik T. , Anthonsen M.W.
      EMBO J.25:3335-3346(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SRC
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF HIS-539 AND ASN-541
    16. 16.
      "Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation."
      Sarkar S.N. , Elco C.P. , Peters K.L. , Chattopadhyay S. , Sen G.C.
      J. Biol. Chem.282:3423-3427(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-759 AND TYR-858;FUNCTION;MUTAGENESIS OF TYR-759
    17. 17.
      "The TLR3 signaling complex forms by cooperative receptor dimerization."
      Leonard J.N. , Ghirlando R. , Askins J. , Bell J.K. , Margulies D.H. , Davies D.R. , Segal D.M.
      Proc. Natl. Acad. Sci. U.S.A.105:258-263(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOUBLE-STRANDED RNA-BINDING;HOMODIMERIZATION
    18. 18.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-52 AND ASN-57
      tissue: Liver.
    19. 19.
      "Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling."
      Garcia-Cattaneo A. , Gobert F.X. , Muller M. , Toscano F. , Flores M. , Lescure A. , Del Nery E. , Benaroch P.
      Proc. Natl. Acad. Sci. U.S.A.109:9053-9058(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROTEOLYTIC PROCESSING;SUBCELLULAR LOCATION;INTERACTION WITH UNC93B1
    20. 20.
      "The molecular structure of the Toll-like receptor 3 ligand-binding domain."
      Bell J.K. , Botos I. , Hall P.R. , Askins J. , Shiloach J. , Segal D.M. , Davies D.R.
      Proc. Natl. Acad. Sci. U.S.A.102:10976-10980(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 22-703;FUNCTION;DISULFIDE BONDS;SUBUNIT;GLYCOSYLATION AT ASN-52; ASN-70; ASN-196; ASN-252; ASN-265; ASN-275; ASN-291; ASN-398; ASN-413; ASN-507 AND ASN-636;IDENTIFICATION BY MASS SPECTROMETRY
    21. 21.
      "Crystal structure of human toll-like receptor 3 (TLR3) ectodomain."
      Choe J. , Kelker M.S. , Wilson I.A.
      Science309:581-585(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 27-700;DISULFIDE BONDS;GLYCOSYLATION AT ASN-124; ASN-252; ASN-275; ASN-291; ASN-398; ASN-413 AND ASN-507
    22. 22.
      "Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure."
      Luo J. , Obmolova G. , Malia T.J. , Wu S.J. , Duffy K.E. , Marion J.D. , Bell J.K. , Ge P. , Zhou Z.H. , Teplyakov A. , Zhao Y. , Lamb R.J. , Jordan J.L. , San Mateo L.R. , Sweet R.W. , Gilliland G.L.
      J. Mol. Biol.421:112-124(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.52 ANGSTROMS) OF 22-702 IN COMPLEX WITH ANTIBODY;DISULFIDE BONDS;SUBUNIT;DS-RNA BINDING REGIONS;GLYCOSYLATION AT ASN-52; ASN-70; ASN-124; ASN-247; ASN-252; ASN-265; ASN-275; ASN-291; ASN-398; ASN-413 AND ASN-507
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HSE2 SER-554
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PHE-412
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