Protein name:
Toll-like receptor 3 ;
Alternative:
CD:
CD283 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MYD88 via their respective TIR domains. Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with TICAM1. Homodimer formation is triggered by ligand binding and is required for TLR3 signaling. Binding of double-stranded RNA is required for the interaction with SRC.
Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Subcellular Location:
Endoplasmic reticulum membrane
Single-pass type I membrane protein
Endosome membrane
Protein Attributes:
50:
MRQTLPCIYF | WGGLLPFGML | CASSTTKCTV | SHEVADCSHL | KLTQVPDDLP |
100:
TNITVLNLTH | NQLRRLPAAN | FTRYSQLTSL | DVGFNTISKL | EPELCQKLPM |
150:
LKVLNLQHNE | LSQLSDKTFA | FCTNLTELHL | MSNSIQKIKN | NPFVKQKNLI |
200:
TLDLSHNGLS | STKLGTQVQL | ENLQELLLSN | NKIQALKSEE | LDIFANSSLK |
250:
KLELSSNQIK | EFSPGCFHAI | GRLFGLFLNN | VQLGPSLTEK | LCLELANTSI |
300:
RNLSLSNSQL | STTSNTTFLG | LKWTNLTMLD | LSYNNLNVVG | NDSFAWLPQL |
350:
EYFFLEYNNI | QHLFSHSLHG | LFNVRYLNLK | RSFTKQSISL | ASLPKIDDFS |
400:
FQWLKCLEHL | NMEDNDIPGI | KSNMFTGLIN | LKYLSLSNSF | TSLRTLTNET |
450:
FVSLAHSPLH | ILNLTKNKIS | KIESDAFSWL | GHLEVLDLGL | NEIGQELTGQ |
500:
EWRGLENIFE | IYLSYNKYLQ | LTRNSFALVP | SLQRLMLRRV | ALKNVDSSPS |
550:
PFQPLRNLTI | LDLSNNNIAN | INDDMLEGLE | KLEILDLQHN | NLARLWKHAN |
600:
PGGPIYFLKG | LSHLHILNLE | SNGFDEIPVE | VFKDLFELKI | IDLGLNNLNT |
650:
LPASVFNNQV | SLKSLNLQKN | LITSVEKKVF | GPAFRNLTEL | DMRFNPFDCT |
700:
CESIAWFVNW | INETHTNIPE | LSSHYLCNTP | PHYHGFPVRL | FDTSSCKDSA |
750:
PFELFFMINT | SILLIFIFIV | LLIHFEGWRI | SFYWNVSVHR | VLGFKEIDRQ |
800:
TEQFEYAAYI | IHAYKDKDWV | WEHFSSMEKE | DQSLKFCLEE | RDFEAGVFEL |
850:
EAIVNSIKRS | RKIIFVITHH | LLKDPLCKRF | KVHHAVQQAI | EQNLDSIILV |
900:
FLEEIPDYKL | NHALCLRRGM | FKSHCILNWP | VQKERIGAFR | HKLQVALGSK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Human Toll-like receptor 3
ELISA Kit for Human Toll-like receptor 3
ELISA Kit for Human Toll-like receptor 3
CLIA Kit for Human Toll-like receptor 3
CLIA Kit for Human Toll-like receptor 3
CLIA Kit for Human Toll-like receptor 3
Polyclonal Antibody for Human Toll-like receptor 3
Polyclonal Antibody for Human Toll-like receptor 3
Polyclonal Antibody for Human Toll-like receptor 3
Monoclonal Antibody for Human Toll-like receptor 3
Monoclonal Antibody for Human Toll-like receptor 3
Monoclonal Antibody for Human Toll-like receptor 3
Protein for Human Toll-like receptor 3
Protein for Human Toll-like receptor 3
Protein for Human Toll-like receptor 3
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PHE-412
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue :
Neuron .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PHE-412
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT PHE-412
tissue :
Testis .
tissue :
Thymus .
7.
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
Mural R.J.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Placenta .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 24-38
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH TICAM1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH TICAM1
tissue :
Lung .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBUNIT;MUTAGENESIS OF CYS-95; CYS-122; ASN-196 AND ASN-247
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SRC
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS OF HIS-539 AND ASN-541
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-759 AND TYR-858;FUNCTION;MUTAGENESIS OF TYR-759
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DOUBLE-STRANDED RNA-BINDING;HOMODIMERIZATION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-52 AND ASN-57
tissue :
Liver .
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PROTEOLYTIC PROCESSING;SUBCELLULAR LOCATION;INTERACTION WITH UNC93B1
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 22-703;FUNCTION;DISULFIDE BONDS;SUBUNIT;GLYCOSYLATION AT ASN-52; ASN-70; ASN-196; ASN-252; ASN-265; ASN-275; ASN-291; ASN-398; ASN-413; ASN-507 AND ASN-636;IDENTIFICATION BY MASS SPECTROMETRY
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 27-700;DISULFIDE BONDS;GLYCOSYLATION AT ASN-124; ASN-252; ASN-275; ASN-291; ASN-398; ASN-413 AND ASN-507
22.
"Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure."
Luo J.
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Obmolova G.
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Malia T.J.
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Wu S.J.
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Bell J.K.
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Ge P.
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Zhou Z.H.
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Lamb R.J.
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Jordan J.L.
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San Mateo L.R.
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Sweet R.W.
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Gilliland G.L.
J. Mol. Biol.421:112-124(2012)
[
PubMed ]
[
Europe PMC ]
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Cited for : X-RAY CRYSTALLOGRAPHY (3.52 ANGSTROMS) OF 22-702 IN COMPLEX WITH ANTIBODY;DISULFIDE BONDS;SUBUNIT;DS-RNA BINDING REGIONS;GLYCOSYLATION AT ASN-52; ASN-70; ASN-124; ASN-247; ASN-252; ASN-265; ASN-275; ASN-291; ASN-398; ASN-413 AND ASN-507
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Jouanguy E.
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Ugolini S.
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Leonard J.
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Hamilton C.
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Rozenberg F.
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Science317:1522-1527(2007)
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Cited for : VARIANT HSE2 SER-554
24.
"Toll-like receptor 3 and geographic atrophy in age-related macular degeneration."
Yang Z.
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Stratton C.
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Francis P.J.
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Kleinman M.E.
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Tan P.L.
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Gibbs D.
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Tong Z.
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Chen H.
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Zeng J.
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Ma X.
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Luo L.
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Hinton D.R.
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Hamon S.C.
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Simmons E.
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Yu B.
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Sunness J.S.
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Jorde L.
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Parmigiani G.
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Zack D.J.
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Ambati J.
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Zhang K.
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N. Engl. J. Med.359:1456-1463(2008)
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Cited for : VARIANT PHE-412
25.
Yang Z.
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Stratton C.
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Francis P.J.
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Kleinman M.E.
,
Tan P.L.
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Gibbs D.
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Tong Z.
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Chen H.
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Constantine R.
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Yang X.
,
Chen Y.
,
Zeng J.
,
Davey L.
,
Ma X.
,
Hau V.S.
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Wang C.
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Harmon J.
,
Buehler J.
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Pearson E.
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Patel S.
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Kaminoh Y.
,
Watkins S.
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Luo L.
,
Zabriskie N.A.
,
Bernstein P.S.
,
Cho W.
,
Schwager A.
,
Hinton D.R.
,
Klein M.L.
,
Hamon S.C.
,
Simmons E.
,
Yu B.
,
Campochiaro B.
,
Sunness J.S.
,
Campochiaro P.
,
Jorde L.
,
Parmigiani G.
,
Zack D.J.
,
Katsanis N.
,
Ambati J.
,
Zhang K.
more...
N. Engl. J. Med.359:1859-1859(2008)
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Cited for : ERRATUM