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Index > Protein center > TLR4(Gene name) > Bovine
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  • TLR4 (Gene name),
  • Toll-like receptor 4 (Protein name ),  TLR4_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TLR4;
    Protein name:
    Toll-like receptor 4;
    Alternative:

    CD:
    CD284;
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4 (By similarity). Interacts with CNPY3.
    Function:
    Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    841
    Sequence:
    50:
    MMARARLAAA | LIPATAILSC | LRTESWDPCV | QVVPNISYQC | MELNLYKIPD | 
    100:
    NIPISTKMLD | LSFNYLRHLG | SHNFSSFPEL | QVLDLSRCEI | KIIEDDTFQG | 
    150:
    LNHLSTLILT | GNPIQSLAWG | AFSGLSSLQK | LVAVETNLVS | LNDFPIGHLK | 
    200:
    NLKELNVAHN | FIHSFKLPEY | FSNLPNLEHL | DLSNNKIQNI | YYEDVKVLHQ | 
    250:
    MPLLNLSLDL | SLNPLDFIEP | GTFKEIKLNG | LTLRSNFNSS | HVMKTCIQGL | 
    300:
    AGLKTNRLVL | GEFKNERKLQ | RFDRSFLEGL | CNLTIEQFRI | AYLDKFSGDD | 
    350:
    TDLFNCLANV | SVISLLSISL | GSLQALLKDF | RWQHLEIINC | DFDKFPALKL | 
    400:
    SSLKKFVFTD | NKDISTFTEF | QLPSLQYLDL | KRNHLSFKGC | CSHTDFGTTN | 
    450:
    LKHLDLSFND | VITLGSNFMG | LEQLEHLDFQ | HSTLKQINAF | SAFLSLRNLR | 
    500:
    YLDISYTNIR | IVFHGIFTGL | VSLQTLKMAG | NSFQNNLLPD | IFTELTNLTV | 
    550:
    LDLSKCQLEQ | VAQTAFHSLS | SLQVLNMSHN | KLLSLDTFLY | EPLHSLRILD | 
    600:
    CSFNRIMASK | EQELQNLPRS | LTWLNLTQNA | FACVCEHQSF | LQWVKDQRQL | 
    650:
    LVGAEQMMCA | EPLDMEDMPV | LSFRNATCQL | SKTIISVSVV | TVLLVSVVGV | 
    700:
    LVYKFYFHLM | LLAGCKKYGR | GESIYDAFVI | YSSQDEDWVR | NELVKNLEEG | 
    750:
    VPPFQLCLHY | RDFIPGVAIA | ANIIQEGFHK | SRKVIVVVSQ | HFIQSRWCIF | 
    800:
    EYEIAQTWQF | LSSRAGIIFI | VLQKLEKSLL | RQQVELYRLL | SRNTYLEWED | 
    841:
    SVLGRHVFWR | RLRKALLAGK | PQSPEGTADA | ETNPQEATTS | T
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    UniGene:
    Pfam:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine Toll-like receptor 4
    Cat.:
    E0753h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Bovine Toll-like receptor 4
    Cat.:
    E0753m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Toll-like receptor 4
    Cat.:
    E0753r
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Bovine Toll-like receptor 4
    Cat.:
    E0753p
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Bovine Toll-like receptor 4
    Cat.:
    E0753b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Toll-like receptor 4
    Cat.:
    U0753b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Toll-like receptor 4
    Cat.:
    U0753h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Toll-like receptor 4
    Cat.:
    U0753p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Toll-like receptor 4
    Cat.:
    U0753r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine Toll-like receptor 4
    Cat.:
    U0753m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Bovine Toll-like receptor 4
    Cat.:
    P0753Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Toll-like receptor 4
    Polyclonal Antibody for Bovine Toll-like receptor 4
    Cat.:
    P0753Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Toll-like receptor 4
    Polyclonal Antibody for Bovine Toll-like receptor 4
    Cat.:
    P0753Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine Toll-like receptor 4
    Monoclonal Antibody for Bovine Toll-like receptor 4
    Monoclonal Antibody for Bovine Toll-like receptor 4
    Monoclonal Antibody for Bovine Toll-like receptor 4
    Cat.:
    M0753h
    Price:
    Please sign in first.
    Packing:
    40ug
    Monoclonal Antibody for Bovine Toll-like receptor 4
    Protein for Bovine Toll-like receptor 4
    Protein for Bovine Toll-like receptor 4
    Cat.:
    R0753h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Bovine Toll-like receptor 4
    Protein for Bovine Toll-like receptor 4
    Protein for Bovine Toll-like receptor 4

    R&D Technical Data

    12% SDS-PAGE analysis

    12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Bovine Toll-like receptor 4 (TLR4)."
      Guionaud C.T. , Dubey C. , Jungi T.W.
      Submitted (2001-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Role of bovine TLRs in antigen presentation."
      Werling D. , McGuire K. , Glass E.
      Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "cDNA cloning and sequence analysis of signalling molecules on bovine toll-like receptors."
      Wang X.P. , Xu S.Z. , Gao X. , Ma T.H. , Ren H.Y. , Chen J.B.
      Submitted (2006-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Mammary gland.
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